Adam surprises everyone when he fulfils one of Cathy's wishes. Cathy's estranged Dad visits her. Andrea gets the opportunity of a lifetime. Sean has mixed feelings about his impending kidney surgery.

Rebecca reveals a secret to Sean that reconnects them. Dr. Todd tells Paul and Cathy that the bee therapy did not work. Cathy reconsiders her options. Adam finally shows his softer side in an unexpected way.

Cathy is inspired by Lee’s passing to ring in the New Year in an unexpected way; burdened by financial issues, Paul tries a new tactic with the insurance agency; Adam makes a surprising connection with Dr. Todd.

Dr. Sherman pays a visit to Cathy, who has checked herself into a hospice and is experiencing problems with her new roommate. Adam confronts Paul about his lack of parental guidance. Andrea seeks inspiration from Cathy.

As Cathy prepares for her trip to Italy, she receives an amicable call from Lee. Elsewhere, Paul uncovers a secret about Myk while Adam discovers one about Poppy.

Cathy plans Adam's sixteenth birthday party. Andrea struggles settling in with her new room-mate at fashion school. Paul brings in a new assistant.

Dr. Todd and Cathy go to see the Bee Man to seek non-traditional treatment for her cancer. Paul is overly supportive of Cathy around the house. Sean gives Adam relationship advice about Mia.

Adam's shocking indiscretion threatens Cathy's new job as a swim coach; sparks fly between Andrea and Myk, a Ukrainian coworker that Paul is mentoring; Sean seeks advice on taking the "next step" with Rebecca.

Sean feels inspired to donate to charity. Cathy upsets Paul when she signs him up to an online dating service. Andrea struggles to impress her tutor, Isaac Mizrahi.

Cathy invites friends and family to a Thanksgiving dinner, but a long-hidden secret she brings to light causes trouble.

Rebecca deals with the grief over her miscarriage in an unexpected way which leads Cathy to reconnect with old friends; Andrea's relationship with Myk heats up; Adam is taken by surprise when he finally meets the girl he's been chatting with in an online cancer support group.

Cathy and Sean hit the open road to visit their dad. During the trip, Cathy tells Sean she has cancer. Sean falls apart at the news, so Cathy pretends it was a big joke. Adam gets drunk while under the supervision of Paul. Marlene finds Adam on the front lawn puking. Marlene will keep it a secret, but Adam is in further servitude to her.

Paul seeks support from people at his work place, but gets more than he bargained for. Sean pulls away from Rebecca when it appears she’s getting too serious. Cathy, Marlene and Rebecca have a girl’s lunch at a strip joint -- which unexpectedly influences Cathy’s thoughts about her cancer. Adam meets a girl, Mia, at the bus stop.

Cathy helps Lee check a few items off his "bucket list;" Poppy takes Adam to her high school reunion; a distraught Sean takes issue with his new neighbors.

Cathy learns from Dr. Todd just how little time she has left, and for the first time in her life, starts to appreciate her body. Paul tries to make sense of his wife's request to live apart for the summer by signing up for couples therapy. Adam, desperate to get away from his "crazy" mom, attempts to sneak off to soccer camp without her knowing.

For her birthday, Paul surprises Cathy with a party just when Lenny has invited her to an art opening on the Bahamas. At the party, Cathy's brother begins a fling with Cathy's eccentric college friend Rebecca. Meanwhile, picks up Marlene who is wandering around in the backyard.

Cathy’s unexpected visit to Andrea’s home yields many surprises. Later, Cathy seeks spiritual advice at church and while helping around the house. Rebecca calls it quits with Sean in order to reconcile her friendship with Cathy. Adam apologizes to Andrea. Paul sleeps with Tina. Cathy reveals to Paul she has cancer.

Lee takes Cathy to a Tibetan doctor to deal with her high blood pressure. Feeling jealousy of Lee, Paul takes Cathy and Lee out for an evening, while Adam interfere with Andrea's date.

After being diagnosed with melanoma, Cathy decides to build a pool in her backyard, much to the chagrin of her older curmudgeonly neighbor, Marlene. Cathy’s son, Adam, plays pranks on her while her husband Paul tries to get back in her good graces. Cathy also tries to reconnect with her willfully homeless brother Sean, and devises a weight-loss plan for Andrea, one of her summer school students.

Cathy pays back Maxine and Dave, and confronts Joy about Paul; Sean discovers the pros and cons of his relationship with Tim and Giselle; Paul learns something new about Cathy.

When Cathy's attempt to connect to the people closest to her fails, she signs up for a well-meaning but overbearing cancer support group. Adam rebuffs Cathy's attempts to connect with him, so she decides to put together a dinner party with Andrea, Sean and Daphne. Meanwhile, Paul tries to win back his wife's love with an elaborately romantic gesture. Marlene discovers Cathy's cancer secret in a most unusual way.

Cathy meets someone new to feel sexy again. Meanwhile, Cathy's eccentric brother Sean tries to keep his building and Adam is caught while watching pornography.

Dr. Todd tells Cathy that she’s been rejected from the clinical trial. Sean sets up Marlene on a date. At a party, Adam gets into a fight with Andrea. Cathy and Lenny take ecstasy together. Paul catches Cathy and Lenny having sex. Paul gets too drunk at the dinner to celebrate his promotion, forcing Adam to drive home. Paul tells Cathy he wants a divorce.

Cathy is intrigued by Lee, a fellow cancer patient she meets on the first day of her clinical trial; Adam's downward spiral continues with a fight at school and refusal to take responsibility for his actions with Emily; Sean is worried that his new house is haunted.

After an argument with Lee and a revealing dinner with Dr. Sherman, Cathy (Laura Linney) comes to a major crossroads. Elsewhere, Adam searches for his AWOL uncle and an impulsive Andrea makes a decision about Myk.