Drew is left comatose after a car accident. He enjoys a fantasy world where he is surrounded by scantily clad models, dines from pizza trees, and has a makeup-free Mimi as his slave. Meanwhile, his friends hold a bedside vigil. Mimi even kisses him in the hopes that the shock to his system would wake him. The doctor gives him an injection to help him come around, but it doesn't work. Drew insists that he would rather stay in the coma, as it seems much better than his real life. As a last resort, the doctor suggests that they remove him from the respirator. The shock will cause him to either come out of the coma or die. Steve (who has power of attorney) hopes to avoid this option. The gang tries surrounding Drew with familiar things, but there is no change in his condition. After Drew is removed from the respirator, he takes a test to see if he can get into heaven. He learns that he has been accepted. Mimi goes into labor in Drew's room.

Lewis struggles to find a date to his ex-girlfriend's wedding. All of his friends (and even Mimi) try to help him out, but he inevitably drives all the women away with his creepy comments. Lewis becomes extremely depressed and refuses to get off of Drew's couch. Oswald brings in Lewis's mother, who reveals to Drew that Lewis has an IQ in the genius range. His family always kept the truth from him in the hopes that he could live a normal life. Lewis is thrilled by the news. He attends a Mensa meeting, but still strikes out with every woman. He begins to fear that he will never fit in, until a woman shows up at the meeting to deal with the building's rat problem. She has a high IQ and shares Lewis's love of bizarre trivia about serial killers, etc. They immediately establish a connection and set off to catch the rat together.

Mr. Wick is roped into dog-sitting Mrs. Louder's prized show dog; it's very valuable because of its unique coat and breeding capabilities. Wick ditches the responsibility by leaving the dog with Drew without consulting him. Kate drops the dog off at Drew's and doesn't have time to leave a note. When Drew gets home, he assumes the dog is a stray and takes it to the vet. Kate returns later and is horrified to find the dog shaved and neutered.

The guys' mothers come to town for a special Mother's Day brunch at the Warsaw. Kate introduces everyone to her new stepmother, who looks exactly like her. Beulah praises Steve for getting married and starting a family of his own, and all of the mothers nag their kids to follow his example. A web site publishes a list of the biggest Internet porn users in Cleveland, which is scrolled onscreen during the news. The moms are mortified to discover that Drew, Kate, Lewis, Oswald and Wick are on the list. The gang sues to have its names taken off the list. The mothers, led by Beulah and Mrs. Wick, decide to move back in with their kids to get their lives back on the right path. They throw out all of their porn and beer and generally drive them crazy. Mimi's grandmother feels that the women should lighten up. After Beulah catches Drew drinking, she and the other mothers elect to testify on behalf of the anti-porn users site. Drew represents the gang after its lawyer proves incompete

Kellie finally agrees to marry Drew, but their wedding plans are thrown into disarray when she goes into labor.

Drew starts his own beermaking business after learning there's trouble brewing at the store and that he could be getting canned.

Drew entertains a group of investors from Vietnam who are considering opening a store in Hanoi. They have drinks at the Airport Ramada Inn. When the house band goes on break, Drew and the guys fulfill the investors' request for music by taking the stage for a song. The manager feels that they are better than the regular band and asks them to play for a week. Drew fears that this would be too much of a distraction and wants to focus on his new job. He changes his mind after a groupie hits on him in the parking lot. The guys audition guitar players, and hire a free-spirited guy named Ed. Kate becomes dissatisfied with her job and tries to get fired. Drew agrees to let her go, but promises to re-hire her if she can't find a better job in a week. She doesn't have any luck, but Drew backs out of the deal because he wants her to find the kind of happiness he now has with his band. Drew blows off a party at Mrs. Louder's house, and later skips work to fool around with Darcy. The ho

Darcy breaks up with Drew after he admits that he is not a full-time musician. He starts spending a lot of time at his computer, and begins a steamy on-line affair with an anonymous woman. He becomes concerned after learning that his chat room girlfriend works at a department store and has a large collection of troll dolls. When he confirms that it is Mimi, Drew begins showering compulsively. He feels extremely awkward when he and Mimi run into each other while visiting Wick in rehab. Mimi does not realize that she was involved with Drew, and is angry that she hasn't heard from her online man for a while. Drew gets really drunk and writes her a kiss-off note in which he claims to be Bill Clinton. Meanwhile, Oswald grows concerned about his mother's financial status after her birthday check to him bounces. He learns that her business partner deserted her, and that she may lose her beauty salon and house. Oswald follows Lewis's advice and agrees to test breast implants for DrugC

The cast laments the show's inability to pick up even a single major Emmy nomination. Hoping to win over Emmy voters, they decide to make a ""very special"" episode filled with tragedy and controversial issues. Drew and Lewis deliver a homeless woman's baby in the living room. She promptly pulls a gun on them and tries to rob them. Drew responds by buying a gun and making an over-the-top speech about his right to own it. Some latchkey kids move into the neighborhood, and the gang acts irresponsibly around them. Oswald becomes a kleptomaniac. Mimi suffers a recurrence of obsessive-compulsive disorder after losing her clothes in a fire. Wick becomes bulimic. Kate gets a headache, and quickly winds up in the hospital with an incurable illness. Lewis repeatedly makes insensitive comments, and follows each with a spotlit monologue in which he tries to psychoanalyze himself. The doctor gives Drew a medical book and suggests that he might be able to find a cure for Kate...but Drew ca

The gang plays poker with Mr. Wick in the hopes of winning back Drew's job, but their plan fails. Mimi shows up with Steve and gets herself into the game by showing off a wad of cash. She ends up squaring off with Kate in a high-stakes match-up. Kate has a great hand, so she wagers her share of Buzz Beer against Mimi's $5000. Unfortunately, she loses. Mimi quickly manipulates Oswald and Lewis into naming her the new president of Buzz Beer. Her ideas soon help the company increase its profits considerably. Lewis discovers that the cashbox is $2000 short. Everyone blames Drew--because he is out of work and struggling to pay his bills--but he insists that Mimi is setting him up. Oswald suggests that they just let the culprit return the money secretly. Drew's power and telephone are turned off. He admits to Kate that he was borrowing from Buzz Beer in an attempt to pay off his debts. He doesn't want to take money from her because he is used to being the one who helps everyone w

Milan fixes up Drew with her mother, Lindsay, because she wants her to finally meet someone who isn't just after her money. Drew makes the mistake of allowing Lindsay to drive his car, and they are trapped for several hours after she crashes into a ditch. Lindsay finds Drew's lifestyle charming, and wants to continue seeing him. She is scheduled to leave town a few days later, but suddenly announces that she is moving to Cleveland. Drew is alarmed to learn that Lindsay would lose her $500,000 per month alimony if she ever re-married. He predicts that she will soon grow tired of the novelty of living like a poor person. He challenges her to spend one week in his world. She tries her best to adjust to a simple lifestyle, but really doesn't take to it. She begins breaking out in rashes and losing her hair. Drew decides that he is in love with Lindsay for some reason. After he tells her this, she announces that she is leaving. She never really liked him that much, and cannot sur

A 21-year-old man claims to be Oswald's son, the result of a fling at a summer tap dance camp. However, the man bears a striking resemblance to Lewis. Lewis admits to Drew and Kate that he also slept with the girl. He believes that he must be the father, but Oswald argues that Robert actually looks like his mother. The guys arrange for separate outings with Robert, but begin bickering about ""custody"" issues. They finally decide to take a DNA test to find out which of them is the real father. Robert reveals that he is married and has a child of his own, and finally sought out his father because the baby doesn't have a grandpa. He is perfectly happy to have Lewis and Oswald share father/grandfather duties, so they decide to save their friendship by tearing up the results of the paternity test. Meanwhile, Drew's decision to allow the employees to put together the store newsletter proves disastrous.

Drew is still devastated by his break-up with Kate. Steve encourages him to move on with his life, and Oswald and Lewis suggest that sleeping with another woman would allow him to get over Kate and go back to just thinking of her as a friend. Mr. Wick moves in with Drew temporarily to keep up appearances for the INS. Oswald and Lewis run into a heartbroken Kate at the Warsaw and tell her about their advice to Drew. She cannot stand the thought of Drew with another woman, especially so soon after the completely implausible demise of their relationship. She races to the house to stop him, only to learn from Wick that Steve has taken Drew out to meet someone. Drew is less than pleased to find that his beautiful date, Jenny, is Mimi's cousin. Mimi forbids Jenny from dating Drew, but she ignores him. Jenny wants to sleep with Drew right away, so they head back to the house. Meanwhile, Kate gets plastered and decides to sleep with Wick. She eventually realizes that this is wrong an

Lisa, Kate and Mimi are candidates to head the store's personal-services department, and Drew has trouble deciding among them.

Lewis meets a woman at a Babylon 5 convention and gets a date with her. Oswald gets a date with the same woman, Tracy, when he delivers a package to her house. It is an ice cream maker from Lewis, but Oswald doesn't know this because Lewis wrote his name and address in an alien language from Babylon 5. Drew meets Tracy when she complains to him about the store's reluctance to exchange the broken ice cream maker. He also gets a date with her. The guys are excited to have found possible girlfriends, and have no idea that they are dating the same woman. They seek advice from Kate on how to make a first date special. They follow her suggestions a little too literally and freak out Tracy by each following the same routine (paying everyone at the Warsaw to yell out his name when he enters, pulling out a pocket watch, and singing the Commodores' ""Three Times a Lady""). The guys finally run into each other during Drew's date and realize what has happened. Tracy is mortified. Drew late

Drew manages to convince Kate that Nicki made the wedding cake herself because she is crazy. He becomes desperate to clear things up as soon as possible. With Steve's help, Drew realizes that Kate is the woman he really loves. He decides that he will explain everything to her and beg for forgiveness. Before he gets a chance, Kate and Nicki figure it out on their own. They turn to Mimi to help them get revenge. She is reluctant because she wants to prove to Steve that she has changed, but gives them some advice. Drew meets Kate at the Warsaw to confess. She claims that she blames everything on Nicki, and races off to Drew's house in a rage. They stage a fight and throw a mannequin out the window onto his car. They both confront him, and an already furious Nicki leaves after learning that Drew has jilted her. He pleads with Kate for another chance, but she says that she never wants to see him again and peels out in her car.

Larry encourages Drew to lose weight before attending one of his singles mixers. Drew winds up giving up food altogether, but his crash diet has unintended side effects--he can't stop hallucinating about turkeys!

Drew is left bruised and battered as Lily continues to suffer from night terrors. He grows tired of the beatings, but is afraid to talk to her about her problem because he believes she would leave him.

As Drew prepares to marry Lily, his mother notes how upset Kellie seems and realizes that she has strong feelings for Drew. She believes that Drew feels the same way about Kellie. Drew and Lily go through with the wedding, but the union proves to be a brief one when they realize that they really are not right for each other. Drew winds up sharing a dance with Kellie.

The government seizes Drew's house after Larry's antics in the previous episode. They plan to sell it at auction. Drew gets an idea from Nicki to declare bankruptcy on the house to get out of debt and then have Lewis bid on it on Drew's behalf. Tensions erupt as Drew has a difficult time accepting Kate and Oswald as a couple.

Drew and Nicki plan to videotape themselves having sex. The next morning, Drew's parents come to town to celebrate his engagement. Drew tries to tell his mother about a problem with his relationship but is constantly interrupted. Drew eventually tells Beulah he has called off the wedding. She begs Drew to go through with the bachelor party and break the news to George afterward because of how depressed he's been.

Lewis forces Oswald and Drew to shake and make up. Kate tries to come up with a way to tell Oswald she isn't in love with him anymore and wants to call off the wedding. Drew urges Kate to tell Oswald to his face and get it over with. Kate's plan is thwarted when Oswald throws a surprise wedding ceremony for her in Drew's backyard. Kate is at odds with whether to avoid humiliating Oswald or to be true to her heart.

Drew's dog Speedy disappears from DrugCo while taking part in clinical trials for a new canine medication, so the gang breaks into the facility to find him.

Drew is the butt of all jokes at a convention after security finds a naughty little something hidden in his luggage.

The store's Dutch owner draws Drew into his plans to demolish Winfred-Louder to build a parking garage.