When aliens called the Dominators attack Central City, Barry speeds over to Star City to ask the Green Arrow for help in stopping them. Realizing the battle against the Dominators is bigger than they thought, they track down the Legends of Tomorrow, and Barry and Cisco create a breach to bring back a secret weapon – Supergirl. Once all of the super friends are assembled, they come up with a plan to attack but a shocking secret related to Flashpoint is revealed and suddenly no one is sure who they can trust. Meanwhile, Wally wants to join the battle against the aliens but Iris tells him he’s not ready. The crossover starts on Supergirl S02E08 Medusa (I). It continues on Arrow S05E08 Invasion! (III) and DC's Legends of Tomorrow S02E07 Invasion! (IV).

With only 24 hours left until Savitar murders Iris, Barry struggles to save the woman he loves and makes the choice to use any means necessary to do so. Realizing he has one option left to save her, The Flash turns to Captain Cold for help.

Team Flash throws a surprise birthday party for Barry, but things go terribly awry when Ramsey Rosso crashes the festivities.

Barry and the team meet Tracy Brand, a scientist, who may be the key to stopping Savitar. Unfortunately, Killer Frost is also after Tracy so Team Flash must battle their old friend, which proves to be particularly difficult for Cisco. Joe and Cecile’s relationship takes a big turn.

Pariah enlists Black Lightning to help stop the Anti-Monitor after Flash-90 shares what he learned from his battle in ‘Elseworlds.’ With the help of Black Lightning, Barry, Cisco and Killer Frost come up with a plan that could save them all. Meanwhile, Iris has a heart-to-heart with Ryan Choi, while Oliver and Diggle return to an old familiar stomping ground. The crossover starts on Supergirl S05E09 and Batwoman S01E09. It continues on Arrow S08E08 and Legends of Tomorrow S05E01.

As Iris receives word of a career milestone, Barry is suddenly nowhere to be found. In trying to get back home, Barry runs across many familiar faces. Khione continues to figure out her powers, and Chester works on a suit for Allegra.

Caitlin uses her powers to save Barry but as her mother predicted, the effort unleashes her inner Killer Frost. Killer Frost goes on a rampage looking for Dr. Alchemy, kidnapping Julian and battling both The Flash and Vibe. Meanwhile, Joe and H.R. have a heart to heart talk.

With Alchemy and Savitar still looming threats, Barry is unable to focus on the Christmas holiday, and especially his relationship with Iris. Determined to stop Savitar, Barry goes to Earth-3 to get advice from Jay Garrick. Wally wants to help Barry fight Savitar and reveals that he’s been training with H.R, which doesn’t go over well with Barry. As Cisco faces his first Christmas without his brother Dante, old wounds are reopened.

Barry travels to the future to find out Savitar’s still unknown identity in the hopes of saving Iris. Upon his arrival in 2024, Barry encounters future versions of his Team Flash friends, who, following the death of Iris, have become very different people, profoundly impacted by their showdown with Savitar. It will be up to Barry to infuse a sense of hope back into the team, as he proves to be hero his future friends have been waiting for. Meanwhile, back in 2017, the hunt for Killer Frost continues.

While training with Barry, Wally starts to have visions of Savitar, which he hides from the team. A dangerous secret threatens Barry and Iris’ happiness.

Barry and Team Flash come up with a plan to stop Cicada. However, the plan calls for Barry and Nora to travel back in time to gather some key necessities. However, Barry hesitates, concerned about his daughter seeing certain parts of his life. Meanwhile, Sherloque takes his concerns about Nora to Iris, and Caitlin turns up a key asset in the fight against Cicada.

Mark Mardon, having survived his apparent death during the black-matter explosion, returns seeking revenge on Joe for the death of his brother Clyde... and has the same weather-manipulation powers as his deceased sibling.

Wells presents Barry with a life-changing choice. Dr. Martin Stein and Ronnie Raymond return to help the S.T.A.R. Labs team with this final fight.

When Barry Allen and Oliver Queen wake up one morning and realize they have swapped bodies with each other, the two set off to find out what disturbed the timeline to cause such a shift. However, things quickly go from bad to worse when they present their case to Team Flash and the gang doesn’t believe them. Barry and Oliver realize they need Supergirl’s help and travel to Smallville on Earth-38 where they end up meeting Kara’s cousin, Clark Kent, and intrepid reporter, Lois Lane. The crossover continues on Arrow S07E09 Elseworlds (II) and Supergirl S04E09 Elseworlds (III).

As Barry Allen stands on the threshold of his impending death in Crisis, his convictions are tested when the monstrous Dr. Ramsey Rosso infects The Flash with a mysterious, hallucinogenic contagion. Meanwhile, reporter Iris West-Allen uncovers a vast conspiracy.

Barry is living his dream life – his parents are alive, he’s asked Iris West on a date and he can finally be a normal guy as Central City has another speedster, Kid Flash, running around saving the city. When Barry starts forgetting parts of his old life, the Reverse Flash taunts his nemesis and tells him that there will be serious repercussions for Barry and the ones he loves if he continues to live in this alternate universe. In addition to losing his memories, his powers will also start to fade. When disaster strikes, Barry must decide if he wants to continue to live in this world as Barry Allen or return to his universe as The Flash.

Barry realizes the effects from Flashpoint are much greater than he thought. Meanwhile, Barry meets new co-worker Julian Albert and is surprised by Julian's immediate disdain for him.

When Wally starts having dreams about being Kid Flash, Barry realizes he has to tell Wally, Iris and Joe about what happened to Wally in Flashpoint in order to keep him safe.

When a nuclear bomb detonates in downtown Central City, Barry, Jesse Quick and Jay Garrick slow down time by entering Flashtime. As everyone in the city is frozen, the three speedsters push themselves to the breaking point to save the city and everyone in it.

Iris is alarmed by Barry's disappearance and Cecile assures her everything will be ok, but does she know that for certain? Team Flash is affected by a mysterious substance and Khione develops a better understanding of what she can and cannot control.

When Barry suddenly gains the power of speed thinking, he attempts to use his new gift to save Iris. While Barry is thrilled with his new power, Cisco is hesitant to trust it. Meanwhile, Eva must face a shattering truth.

Barry enjoys the annual tradition of tree trimming and gift exchange with Joe and Iris. He gives Iris a touching gift, but the moment is interrupted by Eddie’s arrival.

Barry, Caitlin, Cisco and Joe set a trap for Wells. Cisco uses himself as prey which puts him in grave danger. Meanwhile, Eddie makes a decision regarding Iris, which leaves Joe a bit unsettled.

When Harrison activates the particle accelerator, the team has no choice but to evacuate the five metahuman prisoners. Unfortunately, with time running out, Barry has no choice but to turn to Captain Cold for help. Meanwhile, Eddie escapes but has some surprising news for Iris.

After discovering that Nora is working with Thawne, Barry and Iris disagree about how to handle their daughter in the wake of this shocking news. Team Flash isn't sure they can trust Nora, so they go through her journal to find out exactly how she came to work alongside their greatest nemesis.