Team Flash throws a surprise birthday party for Barry, but things go terribly awry when Ramsey Rosso crashes the festivities.

As Iris receives word of a career milestone, Barry is suddenly nowhere to be found. In trying to get back home, Barry runs across many familiar faces. Khione continues to figure out her powers, and Chester works on a suit for Allegra.

Iris is alarmed by Barry's disappearance and Cecile assures her everything will be ok, but does she know that for certain? Team Flash is affected by a mysterious substance and Khione develops a better understanding of what she can and cannot control.

Barry creates a map book to guide him and Iris throughout their future in order to keep her safe, but the results are not what he expected, and instead, they relive the same day over and over again. Joe has a heart-to-heart with Cecile. A new big bad is introduced to Team Flash and friends and foes, old and new, begin to descend upon Central City.

Barry feels guilty for what happened to Caitlin, and Mark comes up with a plan that makes everyone skeptical. Meanwhile, Red Death looms in Central City and commands that failure is not an option. Joe asks Cecile to make a choice that leads Cecile to think about the greater good. Allegra and Chester take a step in a new direction. Lastly, old friends pay an unexpected visit to S.T.A.R. Labs.

As the Red Death wreaks havoc on Central City, Barry and Iris come up with a plan and turn to Cecile for help. Barry is faced with what he thinks was his greatest mistake and the Red Death's greatest success. Khione wants to help Team Flash, but Barry can't risk losing her. Joe gives Barry a much-needed pep talk.

A seemingly simple mold inspection at S.T.A.R. Labs leads to unexpected time anomalies. Barry and Iris try to make sense of the confusion - and figure out how to get back to their reality. Chester admits a secret to Allegra, which makes things awkward between the two, and Allegra relies on Cecile to act as a buffer. Meanwhile, Khione meets with an old friend of Team Flash.

Barry and Iris start to put together the pieces of what's happening in Central City and believe they know what the Rogues are after. Team Flash works together and recruits some unlikely allies to help, and the plan does not go as Team Flash expects. Meanwhile, Allegra does her best to avoid having a conversation with Chester.

The Flash is forced to make an impossible choice. With the power out in the city, Team Flash calls upon the Rogue Squad to help as Iris is visited by an old friend. Joe and Cecile work on finding a balance.

Team Flash works together to figure out how to protect Barry, all while being very careful who they trust. Cecile is skeptical of the plan after an unsuccessful attempt. Khione's confidence in Chester enables him to convince Cecile to try one more time.

Iris is visited by Nia Nal, as she needs Iris' help. When Iris and Nia fall into a fever dream and explore different possibilities for their lives, Barry, Chester, Allegra, and Cecile desperately try to help them. Meanwhile, Mark entertains Khione, but they have different ideas of what is fun, leaving Khione to feel that Mark is trying to make her something she is not.

The Flash, the fastest man alive, is tasked with his greatest challenge yet, to save the timeline and save existence. Friends old and new gather for an epic battle to save Central City, one last time.

As Barry and Iris prepare for their new life, luck changes for those in Central City. Cecile takes on a case with Allegra's help, involving a string of unfortunate – and highly unexpected – events. Meanwhile, Chester and the team work with Khione to figure out her abilities.