Kimball is injured while helping save some children from a fiery crash. While recuperating at a local home, he learns that his caretakers are the local sheriff and his wife. As if this weren't bad enough, a news article describing Kimball's heroic deeds goes nationwide. The all-seeing Lt. Gerard reads the article, and then goes to the small town to arrest Kimball.

In San Francisco, Kimble is nearly run over by a car driven by Ruth Norton, a young flight attendent distraught over discovering that the man she has been dating for the past four months is married with two children. While recuperating in the hospital, a delirious Kimble flashes back to the months leading upto the night of Helen Kimble's murder and Kimble first seeing the one-armed man fleeing from his house. Followed by Kimble's trial, sentence, and escape from the train wreck. Ruth, who has been keeping a vigil at Kimble's bedside, hears him mutter Helen's name. Thinking that he's in some kind of trouble, Ruth takes Kimble (now going by the alias George Browning) to her apartment to recover. Kimble then gives Ruth advice on her relationship with her boyfriend, Paul, and to put her life problems in perspective.

In the conclusion to Part 1 (from last week), Kimball accompanies a temporarily-blinded Mrs. Gerard to a place where she can phone her husband for help. Mrs. Gerard, who is as inquisitive as her husband, continues to pepper Kimball with questions about himself and his life. As she starts to put the pieces together, she realizes that this man may be Richard Kimball. She begins to form a plan to trap him.

Gerard tracks Kimble to a migrant community in South Texas where he finally captures the fugitive who attempts to flee by train. But a violent hurricane strikes the area and forces them to seek shelter in a fragile barn where most of the farm workers are gathered. But when Gerard is badly injured when the roof collapses on him, Kimble, to the astonishment of the workers, actually helps try to save the lieutenant by helping transport him to another building where the fugitive pleads for a blood doner to save Gerard's life whom has weakened by the loss of blood.

After finding that the one-armed man is not the same man he saw fleeing his house the night of Helen's murder, Kimble flees from Los Angeles, bearly escaping Gerard's dragnet. Tired of running, Kimble hopes to lie low in Santa Barbara and finally confides with Karen his secret. But Gerard tracks Kimble to Santa Barbara from a single clue that Kimble leaves behind at the L.A. County Jail: a match with the word ""sails"" printed on it. When Kimble discovers that Gerard has arrived in town looking for him, with the assistance of Eric, Kimble and Karen flee by sailboat and hope to end the running by faking his and Karen's death in a sailboat accident during a storm at sea.

In Part 1 of a 2-part story, Lt. Gerard and his wife are on a much-needed vacation. When Gerard rushes off to answer the call to duty, an angry Mrs. Gerard decides that enough is enough, and leaves town on the bus. Unbeknownst to her, Kimble is on the same bus. When the bus crashes, Kimble helps her get away from the wreck. Due to a head injury, she is suffering from temporary blindness and doesn't recognize Kimble. Kimble, unaware of who SHE really is, decides to accompany her to a phone where she can contact her husband. Along the way Mrs. Gerard starts asking questions, and is starting to form an image of Kimble, and is intrigued with what she learns. Will she discover his true identity before they reach their destination?

Reporter Barbara Webb spots Fred Johnson, the one-armed man, in a police roundup of suspicious character during a murder investigation. Calling to mind the Kimble case with her publisher boss Herb Malone, Barbara takes a photo of Johnson and publishes it in the local newspaper. The image of the one-armed man draws both Kimble and Gerard to the town. While Gerard waits for Kimble to show up at the police station, the fugitive is outside and sees Johnson in the jail courtyard. But the one-armed man spots Kimble and escapes from the jail and steals a getaway car. Barbara spots Kimble and tells him to get in her car as they chase after the one-armed man. During the chase down a winding mountain road, the one-armed man's car crashes, and Kimble has to tend to Johnson's injuries knowing that he's the only one to clear Kimble of his wife's murder. Unable to speak because of a head injury, Johnson nodds when Kimble asks if he murdered Helen. While Kimble rests, Barbara types a confession paper

Beliving that the one-armed man is in Chicago, Kimble contacts Mike Decker, a newspaper columnist who defended Kimble during his trial. Kimble and Decker organize a city-wide search for the one-armed man. But things get complicated with the arrival of Decker's alcholic wife, Paula, whom gets nervous of Kimble's presence and falls off the wagon. Meanwhile, Gerard learns about Decker's search for a one-armed man and decides to use the writer to set a trap for Kimble.

Kimble's sister Donna summons him home with a possible break in the case: a letter from James Eckhardt, a former U.S. Army captain whom also saw the one-armed man fleeing from the Kimble's house on the night of Helen's murder. Kimble meets with Eckhardt who agrees to help the fugitive out. Eckhardt's story seems strong enough to clear Kimble. But unknown to either men, another witness comes forward: a convict in prison for drug dealing, who reveals that he used to sell heroin to Eckhart for a Korean War battle wound and that Eckhardt was on his way to see him that night to buy some drugs, which is more than enough for Gerard to discredit Eckhardt's testimony.

In rural Wyoming, Kimble seeks refuge from the local constable at a small hotel run by Lois Carter, a young widow whom hires him as a handyman. Kimble soon befriends Lois' son Kenny, a particularly sensitive young boy whom protects Kimble from the police when they arrive looking for him.

While working as a chauffeur in Denver, Colorado, Kimble reluntantly covers for teenager Lauire Ryder after she dents her father's car. But Kimble flees after discovering that Laurie was involved in a hit-and-run. After learning Kimble's idenity, Laurie's father, Dr. Mark Ryder, summons Gerard (along with the entire Kimble file) to Denver where he introduces Gerard to the 2130, a computer that can help capture the fugitive by determining a pattern to his travels. As the 2130 makes progress, Kimble's new travels all over the country end with one close escape after another with the police.

Kimble, working as an apprentice sailmaker in Santa Barbara, California, falls in love with Karen, the daughter of his stern but compassionate boss Lars Christian. But earns scorn from Karen's jealous and overprotective brother Eric. When Lars suffers a heart attack his last wish on his deathbed is to implore Kimble to stay with Karen. Meanwhile, Gerard flies to nearby Los Angeles when he hears about the arrest of a one-armed man for armed robbery and lets the story hit the newspapers, hoping it will flush out Kimble.

Kimble returns to his home town in Illinois after learning that his father, John Kimble, has suffered a heart attack and has donated his medical library to the University of Wisconsin and in the process of selling the family house. While Kimble hides out at the home of his sister Donna and her sympathetic husband Leonard, Kimble blames himself for his father's condition, but is more troubled by his younger brother Ray, whom belives Kimble is guilty and thinks he's to blame for ruining his life since people see Ray as ""the brother of a killer."" Meanwhile, Gerard arrives in town to search for Kimble and focuses on Donna and Leonard whom try to shake off the relentless detective long enough for Kimble to get out of town before Gerard finds him.

Kimble and Sister Veronica continue their journey to Sacramento, unaware that the Nevada State Police have put up a roadblock at the state line. While Kimble deals with a disgruntled ranch hand, named Chuck Mathers, whom suspects his true idenity, Sister Veronica accidently discovers Kimble's idenity through a TV news report. But she does not tell Kimble about her knowledge of who he really is.

Kimble responds to a newspaper ad for a driver and is hired to drive a certain Peggy Franklin and her 10-year-old daughter, Nancy, to California. But Kimble doesn't realize that Peggy has abducted Nancy from her ex-husband, a pathologist named Dean Franklin. Nancy innocently removes a rabbit from Dean's research lab, unaware that the rabbit has meningitis. When Nancy contracts the sickness, Kimble risks keeping his secret safe to save Nancy before she dies.

After learning of the death of his father, Kimble contacts Donna and her husband Len Taft and wants to meet with them. Donna and Len drive to Fort Wayne, Indiana and check into a hotel under assumed names. But their rendezvous is threatned by Mike Ballinger, the former prosecuting attorney at Kimble's trial, who recognizes them and calls on Gerard to set up a trap.

Richard Kimble rides into Tucson, Arizona under the name James Lincoln. He checks into a hotel and finds a job as a bartender at the Branding Iron. He meets Monica Welles (Vera Miles), the piano player who escaped from her stalking jealous husband (Ed Welles) played by Brian Keith.

Kimble is riding on a bus when the police stop it, not to arrest Kimble, but to capture an escaped convict who takes a woman hostage. Kimble disarmes the man, but gets stabbed during the struggle while the convict is shot dead. Not knowing his true identity, the police treat Kimble as a hero and transport him to a hospital for treatment, the prison hospital. When two inmates recognize Kimble in the prison infirmary, they threaten to reveal his identity unless he assists them in their drug smuggling scheme by stealing morphine from the medicine cabinet. Kimble goes along with it, but the drugs get discovered by a guard. One of the prisoners, a innocent orderly named Mickey Deming, gets accused being involved with the smuggling. Kimble recovers and is released. But he risks his freedom when he returns to try to clear Mickey of the charges.

While working as a gas station attendant in New Mexico, Kimble is taken hostage, along with customer Joanne, by two holdup men, named Miles and Vinnie. Once on the road, Kimble pretends that he is a criminal and is heading towards Los Angels for a ""big job."" At the same time, he lets Joanne know that he's on her side, but she's suspicious to his true motives. Once arriving in L.A., Kimble decides to set up Miles and Vinnie to be arrested. But Miles, not trusting Kimble enough, wants him to kill Joanne to prove himself.

On the run from the Nevada State Police, Kimble hitches a ride with Sister Veronica, a nun traveling to Sacramento where she plans to renounce her vows. After fixing her car when it breaks down, Kimble agrees to travel with Veronica only to the nearest train station. But Veronica belives Kimble to be her savior and insists that he tag along with her all the way to Sacramento.

A discarded photograph, with Kimble in the background, leads Gerard to Chicago where he assembles a team of detectives where they trap Kimble within an eight-block radius of the city. With Kimble wondering from place to place, and being recognized by whomever he comes into contact with, he flees from both policemen and local citizens, finding refuge in a small house which is the home of two middle-aged men, named Jake Devlin and Sam Reed, whom have long argued over his innocence.

After getting into a car accident in a rural Kentucky town, Kimble lands in jail by the redneck sheriff who hates outsiders. But Kimble manages to escape with his cellmate Davey ""Fatso"" Lambert. Hiding out at the Lambert ranch, Kimble sees that Davey's father and brother, Frank, treat the slow-witted Davey badly for blaming him for a barn fire years earlier. Kimble tries to prove Davey's innocence as Gerard flies out to Kentucky after learning of Kimble arrest and forms a posse to track him down.

While working as a warehouse worker, Kimble is recognized by the Greek-born owner, Gus Priamos. Gus tells Kimble that he is dying from cancer and has only six months to live and hopes to aid the Fugitive with a scheme to make it look that Kimble has fled the country to Greece. But when Gus' jealous girlfriend Sophie learns Kimble's idenity through a magazine article, she contacts Gerard whom gets a heads-up on Kimble and Gus' plan.

While working as a farm hand in a small Nebraska town, Kimble witnesses the arrest of a local man, named Bellows, whom is suspected of a double murder. Kimble finds himself 'deputized' by Deputy Bowers to help transport Bellows to the county jail, along with four witnesses whom saw Bellows fleeing from a farm house which was the scene of the crime. Although Bellows convinces Kimble that he (like Kimble with his wife's murder) is an innocent victim of circumstantial evidence. But the townsmen remain unswayed. That night when the men get drunk and decide to lynch Bellows, Kimble helps him escape. But Kimble is betrayed when Bellows, whom really did kill the farm couple, escapes and holds another farm couple hostage.

While working as a hotel lifeguard in Reno, Nevada, Kimble is caught in the middle of a feud between the hotel owner Dan Polichek, and his spoiled and rambunctious teenage daughter Christine. 'Chris' belives her father drove away her mother whom commited suicide years ago and she sets out to disgrace Mr. Polichek by provking bar fights, humiliating herself, and goes too far when she pretends to be engaging herself in an affair with the reluctant Kimble.