The high stakes governor election results in violence at the polls, causing multiple victims to arrive at Chastain. Conrad finds common ground with an aggressive patient, helping lead to a diagnosis for his outbursts. Meanwhile, when another patient’s lung collapses, the doctors find a serious root of the issue.

An old army buddy and fellow surgeon visits Conrad at the hospital. Meanwhile, the team is put to the test when they have to save the life of an uninsured and undocumented patient, while simultaneously battling the hospital's administrators, who fear the patient will cost millions. Also, Dr. Bell experiments with a new medication for his tremor and Nic swears to investigate the mystery surrounding missing medical records.

On his first day as an intern, an idealistic Dr. Devon Pravesh faces the harsh realities of medical care, as third year resident Dr. Conrad Hawkins takes him under his wing and teaches his unconventional ways for treating patients. Meanwhile, Conrad goes head-to-head with Chief of Surgery Dr. Solomon Bell, who uses power and intimidation to cover up his mistakes.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong. Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

Conrad receives the call he's been waiting for when a heart becomes available for a patient who has been on the transplant list for two years. But when a congressman is admitted to the hospital after a heart attack, he is prioritized and derails Conrad's patient's surgery. Meanwhile, Nic grows suspicious of one of the doctors after a file goes missing, Dr. Bell tries to manipulate Mina and Devon is put to the test when a patient's condition requires a split-second decision.

Conrad doubts Devon's judgement when a patient who was pronounced dead suddenly revives. Cain and Nick butt heads over the care of a white supremacist. The Raptor and Mina uncover new information about Red Rock Medical.

When Padma's pregnancy takes a dangerous turn, the doctors come together to find a solution and turn to Ian to perform a miracle. Meanwhile, Conrad makes a decision regarding his love life and Devon leads his own clinical trials at Chastain.

The Chastain staff works together to diagnose a mother-daughter pair who both come in with symptoms that make it difficult to determine their conditions. Devon deals with an unexpected visit from his mother and Conrad and Nic try to figure out the best time to tell everyone their big news. Meanwhile, Bell deals with an over-eager fan of his show who ends up needing treatment at Chastain and Mina makes a bold move when she realizes her visa is about to expire.

When Conrad gets a call from his former army commander who is stranded and wounded in the forest, the trip to save him brings lots of old emotions to the surface. Devon and Kit treat a patient who suffers from sickle cell anemia and encourage her to have a hip replacement to help treat her pain. Meanwhile, The Raptor is pulled away in the middle of an intense surgery, Mina is left to put her skills and finish the surgery on her own and Bell works on reconnecting with his stepson after helping him get hired at the hospital.

In trying to find a way to channel his emotions, Conrad puts all his effort in looking for answers. Raptor has a run-in with the police that ends up taking a surprising turn. Meanwhile, Leela begins noticing problems with a surgeon who has been Bell’s mentor.

After a mix-up in the ER causes Conrad to deliver a death notification to the wrong family, he sets out to fix it. Meanwhile, Nic struggles to find a patient's records who has been under Lane's care, Devon forms a bond with an elderly patient and Mina is benched after overreaching in the surgical unit.

A case becomes personal for the staff when Conrad and Bell treat a pregnant woman who is carrying Jake's future adopted child. Upon hearing surprising news from Princess Nadine, Devon contemplates the future of his love life. On the heels of meeting The Raptor's parents, Mina gets a call that causes her to make a bold decision about her future. Meanwhile, Cain grows closer to Rose and Irving and Jessica tie the knot.

An attack by cyber criminals sends the Chastain ER into a tailspin and Kit tries to figure out whether or not to pay the ransom. The Raptor deals with a personal connection to the patients brought into the ER during the attack, leaving them all vulnerable. Meanwhile, Conrad works on balancing life as a new dad and Devon and Leela debate taking the next step in their relationship.

Conrad brings a patient into the hospital who causes a high security crisis. An MMA brawl sends a well-known fighter to Chastain and all hands are on deck. Meanwhile, Bell and Raptor vie for the same position at the hospital, and Leela gets a visit from her sister.

Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out. Leela struggles when given the decision to take full responsibility of her indecisive patient's life and The Raptor continues to try to figure out a care plan for his mother. Meanwhile, both Devon and Kit are stretched far too thin trying to balance everything on their plates

A college professor comes into the ER and Conrad realizes it’s a former patient of his from when he was an intern. Meanwhile, Devon ends up admitting a man – who swears by an anti-aging regimen that he thinks is the answer to eternal life – into the hospital after he collapses.

When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kit gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.

Intending to garner publicity for the hospital, Cain tries to recruit Bell and Kit on a dangerous surgery. The Raptor develops an emotional attachment to a patient. Mina's friend arrives with shocking news.

With Nic's due date steadily approaching, she and Conrad plan a relaxing day off, but their plans are interrupted when a patient with a medical mystery sends them rushing back to Chastain. Devon stays by Rose's side as she starts her clinical trial and things take a turn for the worse. Meanwhile, Kit is under pressure to bring Chastain out of debt.

When a prison doctor believes a death row inmate is lying about his symptoms, Conrad and Raptor are called in to examine him. Meanwhile, Devon sees a traveling British couple who are nervous about the cost of American healthcare, and Kit and Bell meet with the Georgia Governor.

Conrad is hit by a bike and badly sprains his ankle, but works through it when he takes the case of his old medical professor, who is hallucinating visions of her old patients. Devon is tasked with admitting Conrad, who refuses any sort of treatment. Nic tries to navigate her emotions while mourning the loss of a patient and Bell operates on a foreign dignitary with unforeseen complications. Meanwhile, Lane and Bell's relationship grows closer.

When a police officer brings in an injured criminal, the staff must keep him alive. Nic gets roped into a surgical rotation with Cain that leaves her questioning the way he operates. Conrad makes a shocking discovery about the hospital.

On National Nurses' Day, the nurses are severely understaffed and overworked. Cain performs a dangerous surgery on a new patient. Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death.

A renowned pediatric cardiac surgeon proves unfit for surgery. A Dolly Parton drag queen collapses on stage. Nic and Conrad suspect a patient may be the victim of sex trafficking. Nadine delivers some surprising news to Devon.

As Nic struggles with her recovery, her close friend and former Chastain colleague, Billie, comes back to the hospital to support her. Meanwhile, as the hospital transitions from private to public, the search begins for a new CEO, Bell asks a favor of his step-son and Devon sees an opportunity to fix the system.