When Arthur goes off on a date with Carmalita on Hobby Night, Tick builds himself a new sidekick - Little Wooden Boy. Swiss Commandoes are after the notebook of Dr. Vahtoss, Carmalita's father and the inventor of Arthur's flight suit. And Blowhole, a giant long-distance running whale, accidentally swallows everyone, forcing the Tick to light up Little Wooden Boy to cause Blowhole to choke them up. Yep, just another day in The City...

The Tick is sent into space to blow the ""CHA"" out of the Moon from when Chairface tried to write his name in the moon. He blows the letter C up while he's inside it and gets sent through space. While in space he comes across a fantastically large alien named Omnipotus. The Tick befriends him and becomes a janitor on his body. But Omnipotus is an eater of planets and plans to eat the Earth when they get to it.

Betty, Queen of the Ants, leads the ants of the City in revolt - it loses its major defender when the Tick is thoroughly creeped out and checks himself into Captain Sanity's Superhero Sanitarium. Betty and her minions capture the other heroes and lock them up in a giant People Farm, then collect enough glass to build a giant magnifying glass and use sunlight to fry them. Fortunately the Tick regains his (normal) sanity in the nick of time and saves the day.

A small-time bank robber in a stolen Santa Claus costume is chased into an electric billboard, gaining miraculous powers. He becomes Multiple Santa, a villain able to create electric clones of himself. The Tick, Arthur, and their superhero friends are called upon to rid The City of this Christmas menace.

A villain who can animate furniture and make it do her bidding falls in love with Die Fledermaus and tries to take over The City, with hilarious consequences and sexy results.

An alien race called the ""Whats"" kidnap the Tick and Arthur to attempt to thwart their nemesis' the ""Heys"" from destroying the universe.

The Terror sends his so-so villainous son Terry to recover his Desire-O-Vac - he lost it in an epic battle against the Decency Squad decades ago. The Tick is there listening to the old-time Squadders' tales and eventually gets involved, but it's a rebellious Terry and the aged Decency Squad members who save the day.

A camera crew follows the Tick and Arthur around for a day of crime fighting as they do battle with a unique villain.

The evil Brainchild returns and using his Nanny-of-the-Apocalypse, captures the Tick and transforms him into a two-headed bird that speaks bad French. Thus rendered powerless, The Tick is auctioned off by Brainchild, and it's up to the other heroes to sneak into the villain gathering and save him.

El Seed has returned and this time he wants to destroy the whole city by making a 400 year flower bloom in ""the bad way"". This flower will bloom in this ""bad way"", when there is no gentle music around. But when Professor Ichibana, owner of this rare & amazing flower, switches flowers with The Tick and Arthur, these accursed superheroes are tossed in El Seed's salad once again. El Seed creates Rosebud, who manages to steal the flower from Arthur. El Seed makes the flower bloom in ""the bad way"", but even he cannot control it's powers. Only the Tick's opera singing can save the City now...

When Reno entertainers Soren and Frederica lose their prized animal, a trained dolphin, they call upon Arthur (they know his parents), and he and the Tick come to their aid. Little do they know that the dolphin, The Fin, plans to rule the world with his newly-invented Fish Magnet, with which he plans to bury the city in fish. The Tick must cope with his newfound weakness - gambling addiction - but manages to overcome it and beat The Fin by holding his breath longer.

The Tick and Arthur run afoul of Venus, a portly but alluring love goddess/villain, and her sycophantic sidekick, Milo. The villains successfully remove The Tick and Arthur's arms and attach them to a pair of crude lookalike robots. Venus begins a crime spree with the help of the heroes' arms, while The Tick and Arthur evade a police manhunt and try to reclaim their errant extremities and save the day.

A flunky of air conditioner repair school makes a time machine and goes back and kidnaps the greatest inventors of all time so he can go back in time and reinvent everything.