American college student, Amanda Knox, embarks on her study abroad trip in Italy. The morning before Amanda is supposed to leave on a romantic excursion with her new Italian boyfriend, Raffaele Sollecito, things take a sinister turn.

Under mounting pressure, the police try to break Amanda and Raffaele while Edda races to reunite with her daughter.

As Amanda, Raffaele, and Patrick Lumumba enter prison, Giuliano Mignini, their prosecutor, continues to build his case against them while the media's reporting turns Amanda into a monster.

A wrench is thrown in Mignini's case and the search for a new suspect, Rudy Guede, begins. As the highly anticipated trial unfolds, Amanda's choices continue to be scrutinized by the press.

As the trial continues and Raffaele's days in prison turn to months and years, his heartbreaking history unfolds. Raffaele is urged to separate his defense from Amanda's before the verdict comes in.

After the verdict, Amanda falls into a depression, resigning herself to making the best of life in prison. As her appeal approaches and new facts come to light, Amanda decides she will not make the same mistakes that she made in her first trial.

After four years in prison for a crime they didn't commit, Amanda and Raffaele are free. Amanda gets to go home, but everything is unfamiliar and unrecognizable, including herself, and the public is still hell bent on seeing her suffer.