A crippled Confederate colonel, Vautrain, plans to use his power to travel through time to use Jim and Artie to alter history and restore his legs.

Dr. Loveless is back with another plan to take over the world. This time he is using mock-ups of the treasury, prisons and armories to train his men to be able to take over these resources upon his command. After gaining control, Loveless will be instituted as dictator. However, his plan to get rid of West and Gordon goes foul and soon the agents are in hot pursuit of the little villain.

West witnesses eerie phenomena when he takes refuge with a sheriff and his prisoner in an abandoned bayou mansion.

Agents West and Gordon are guarding a museum containing the famous Herzberg jewels but someone still manages to steal the gems. Afterward, a famous painting of a Western scene is removed from the museum by its wealthy rancher-owner. Gordon becomes suspicious and notifies West who discovers that the rancher is partners with Miguelito Loveless, the evil inventor-doctor. His latest invention is a machine that moves real people in and out of paintings. Miguelito's plan is to transpose murderers into famous paintings, distribute the paintings to the rulers of the world, and have them all killed!

While trying to solve a murder, West is charged by a bullet-immune "ghost rider".

West and Gordon are assigned to protect Dr. Raven, who is developing a secret weapon. Raven is a member of a tontine, an investment group whose bylaws state that the surviving member of the group gets the assets of the group. When one of the tontine's members is killed and an attempt is made on Raven's life, the agents decide to investigate. They find a house full of traps and two members of the tontine looking to "survive" the group and take the money for themselves.

An organ grinder and his monkey launch an attack: the man is no less than Count Manzeppi, trying to gain a small wind-up bird toy. The toy contains the Philosopher's Stone, reputed to transmute base elements into gold. The race is on as West and Gordon track Manzeppi to his lair. After repeated setbacks and escapes, Manzeppi is forced to escape in a balloon while his henchwoman Gerda is transformed into a gold statue, and the bird and its stone are seemingly destroyed. At the end, the stone reconstitutes itself on the guys' train after they leave for the night.

Agents West and Gordon are sent to investigate the killings of wealthy industrialists and find that all are linked back to an evil matchmaker, Emma Valentine. She sets the rich men up with her young female employees and then kills them to gain their money and power. West and Gordon manage to escape from the trap she lays and must prevent her next target from getting married.

A mad scientist has invented a robot that looks exactly like West.

A mysterious dragon-like creature is blowing up American ships, and West and Gordon must determine the cause.

James West is tried by a court of cutthroats who believe he has murdered his friend and fellow agent, Artemus Gordon.

Investigating a murder, West falls into the hands of the Eccentrics, a group of assassins controlled by the vicious Count Manzeppi.

West gets involved in a bizarre scheme: a green girl emerges from a fallen spaceship claiming she needs gold for fuel.

While on vacation, the agents receive an odd welcome when they pass through the town of Justice, Nevada. The town turns out to be the hangout for a group of international criminals assembled by Lucrese Posey. West and Gordon discover that Lucrese is planning on heading a worldwide criminal organization. After dealing with the other criminals, the two agents find themselves left with only Lucrese to deal with, a proposition not nearly as simple as it seems.

A mysterious figure in a secret cave makes moves on a chessboard, using a figure of James West. The agents start getting newspapers predicting the deaths of friends that haven't occurred yet. They are unable to stop the deaths but find the shop where the newspapers are printed. Following the trail, Jim is lured into the lair of Mr. Braine, a crippled criminal mastermind who gets about in a steam-powered munitions-armed wheelchair. Braine has planned their every move and response and wants Jim to join him in his plan to kill world leaders and replace them with lookalikes. He already has a double of Artemus Gordon. Braine has anticipated the real Artie sneaking in and taking the place of the lookalike, but Gordon double-bluffs him with a mask underneath his mask. taking advantage of the distraction, Jim confronts Braine and manages to defeat him, blowing up the wheelchair and Braine.

Assigned to protect Stefan, who is to be crowned king in place of his late brother, the agents must deal with the sinister Mr. Talamantes. Talamantes wants Stefan to renounce the throne and will do anything to accomplish this goal. This includes kidnapping Stefan's daughter, Leandra, and manipulating her to do his bidding whenever she hears or reads a certain word.

Dr. Loveless takes a giant step in his plan to rule a world of "little people" --- by reducing West to a six-inch miniature.

West poses as a prisoner at Devil's Island. His assignment: rescue a secret agent who is marked for execution by a savage commandant.

West and Gordon escort President Grant to San Fransisco to dedicate a statue of the late Colonel Wayne Gibson in Gibsonville. West rides ahead to check out the town and finds that it is plagued by a series of broken-neck murders and arguments over lost gold. A further investigation yields the fact that the Colonel is not as dead as was previously thought and that his statue is far from ordinary.

Agents West and Gordon report to Admiral Agnow's San Francisco headquarters, only to find him and three officers dead. The agents believe that the admiral's death ties in with the recent mysterious sinking of the cruiser Youngstown. West and Gordon's next assignment is to guard the Hawaiian king, due to arrive secretly by ship. West encounters Barclay, a Chinese expert on Hawaii, to discuss the king's upcoming visit. But the supposed advisor drugs the agent and announces his plan to sink the ship carrying the Hawaiian king.

Fabian Lavender is a master of disguises, but West is not fooled. Neither is Lavender --- who locks West in one of his gas-filled crypts.

President Grant gives orders to agents James West and Artemus Gordon to deliver prisoner Rimsky to Vladivostok, Russia, in a prisoner exchange for American vice-consul Millard Boyer. When Rimsky dies in an escape attempt, Gordon assumes his identity. The agents are drugged en route and when they come to, are led to believe they're in Russia. West is imprisoned and forced to reveal Rimsky's whereabouts. His captors tie him to a stake while saber-swinging Cossacks ride straight for him. Still in disguise, Gordon meets Rimsky's contact Sazanov, in an effort to uncover the Russians' racket.

On the trail of the source of mysterious tidal waves, the guys finds a fanatical marine environmentalist at the heart of the mystery.

The evil, diminutive Dr. Loveless impoverishes an Indian tribe so that he can become their benefactor -- and their god.

Time is running out for Judge M'Guigan, who is threatened by a bomb-throwing clockmaker.