Scully and Mulder investigate when an art gallery displaying offensive artwork is bombed, and need to discover a way to communicate with the comatose perpetrator to try and prevent a future attack.

While investigating human organ theft, Mulder and Scully uncover a mysterious cult consumed with macabre rituals.

Mulder and Scully cross paths with two women who are identical and have followed each other across 17 states in the last three years, causing chaos and mayhem wherever they are.

Mulder and Scully learn that they aren't the only ones desperately searching for their long-lost son, William. The very fate of the world may depend on it.

The Lone Gunmen call Mulder and Scully to a virtual reality development lab where they learn that one of the program testers was killed inside the computer generated game environment by the digital image of a woman. Needing to get his yah-yah's, Mulder enters the game to fight the woman, but Scully must step in to save him.

The unearthing of an ancient Ecuadorian Amaru urn and its removal to America despite protests leads to a series of deaths linked to a shaman spirit released by the urn.

When an unexpected person comes to Mulder's rescue, Mulder refuses to slip north over the border to safety. Instead, he heads southwest to the Anasazi ruins of New Mexico seeking a mysterious wise man who the Indians call "The Keeper of the Truth".

The season concludes with people all across the country falling gravely ill. A widespread panic develops and Scully looks within to find a cure. Meanwhile, Mulder confronts the man he believes to be behind it all, but another figure from Mulder and Scully's past may prove to be the key to their salvation.

Mulder and Scully rush to find an on-the-run William while the Cigarette Smoking Man pushes forward with his ultimate plan.

A mysterious dog thought to be the last of a rare Asian breed is responsible for several murders which Mulder and Scully are investigating. Now the agents have to find a way to stop the dog before it kills again.

An Indian mystic whose son died in a chemical plant accident smuggles himself into the United States and takes his revenge on two families in suburban Washington, D.C.

Mulder and Scully are contacted by a communications specialist from NASA who shows them evidence of sabotage in the space programme.

After an FBI raid on a doomsday cult called the "Temple of the Seven Stars", Mulder meets Melissa, a cultist who claims to have known him in a previous life during the American Civil War. Scully believes the woman is a delusional schizophrenic, but Mulder allows himself to be drawn into her fantasies.

Snakes are killing the unrighteous, but Mulder and Scully doubt that this is a case of divine intervention.

Agent Reyes takes the lead while investigating an X-file case, surrounding a man found skinned alive after having visions of seeing other people appearing skinned alive. Reyes calls on Scully's expertise to help on the investigation, which pays off when Scully finds a link to a case from 1960.

Scully, Doggett and Reyes investigate an old case that Doggett worked on as a cop in Brooklyn, dubbed "The Screwdriver Killer". They try to determine whether the man who was convicted and has just been released from prison was actually the man responsible for the murders.

A chilling secret is revealed when an old friend reaches out to Mulder and Scully in a seemingly impossible way.

Mulder, back on the X-Files but alone for the first time, investigates a series of vampire-like murders in Los Angeles and finds himself falling for the one woman that may be the prime suspect.

After several African-American men are killed and the color is drained from their skin, Mulder learns about the Teliko, an African folktale about a creature who must suck the pigmentation from a persons body in order to survive.

Mulder and Scully suspect that hexcraft is the source of threats against a doctor's family.

Mulder and Scully watch a movie with themselves as characters and are thoroughly disgusted at how they and their case are portrayed on the big screen. They recount how 18 months earlier they were followed around by a Hollywood producer while investigating a case concerning The Lazarus Bowl - a mythical piece of pottery reputed to have inscribed on it the words that Jesus Christ spoke when he raised Lazarus from the dead.

When a real estate agent is shot inside a prison cell by someone who apparently fired from the roof, Scully and Doggett track him to two exterminators, one of whom has x-ray vision.

A man whose blood is rapidly changing into metal alloy enacts revenge on those who caused his condition.

Special Agent Reyes enlists Mulder's help in investigating a supernatural killer's connection to the unsolved murder of Agent Doggett's son, Luke.

Agent Doggett investigates the death of an EPA official after his car is forced off a bridge by a woman he picked up. He asks for assistance on the case from Scully, who has returned to her teaching position at the FBI Academy in Quantico.