Bash and Mags race to save a woman with mysterious symptoms who was nearly killed by their team's medical error. Theo tries to help a gravely ill teen and his family deal with the possibility that medical hope has run out.

When an explosion takes place near the hospital, Bash runs toward the danger. Mags treats a patient without all the information she needs, and June struggles to take initiative. When a schoolgirl is brought into the hospital in cardiac arrest, Theo does everything he can to save her. Through all the chaos, Claire takes the time to help a teenage girl in need.

Bash's life is scrutinized during his citizenship interview; when treating survivors of a building fire, Theo needs Bash's help with a scared young boy; Mags helps a recovering addict who swallowed her keys; June and Bash treat estranged brothers.

Bash wants to make things right with Amira after their lives are turned upside down once again.

Bash and Amira settle into a new environment, while at the hospital Bash helps a worried couple expecting their first child. Dr. Bishop puts Mags to the test by personally evaluating her performance in the emergency department. Meanwhile, Theo is surprised by his reaction in the face of an altercation, and Attending Dr. Wendy Atwater gives June an interesting case.

Bash's psychiatrist suggests an unexpected form of therapy. Mags gets evicted and meets an old patient who holds a grudge. Theo makes some questionable choices with a patient's mother. June's personal and professional worlds collide.

A software glitch takes down the emergency department; Bash explores new terrain; Mags searches for a new cardiologist; June is fed up with her bosses; Theo attempts a stable dating life.

Bash and Mags support each other through new challenges while treating an older couple who show up at the hospital glued together. Theo is called out by Liz Bergeron about his repeated inability to follow hospital rules.

As Bash's future at the hospital hangs in the balance, he diagnoses a young patient with a rare disease that could have been prevented. Mags is faced with a case she cannot solve, as June tries to keep her personal life private. Meanwhile, Theo drives through the night to spend a day with his family in Sudbury.

Bash reels from Amira's bold decision; tensions flare at an after-work dinner party; Devi struggles to keep her staff in line as turmoil erupts over her leadership; Mags treats a highly sensitive person; Theo considers breaking some hospital rules.

Bash tries saving a couple whose wedding was waylaid by gunfire; Mags' demanding teen patient needs birth control; June struggles with an old habit; an activist patient puts Theo in his place.

When Bashir Hamed finds himself at the site of a tragic accident, his medical training takes over as he works to save the wounded. At York Memorial Hospital, the staff treat patients from the accident while concerns arise about their Chief of Emergency Medicine, Dr. Jed Bishop.

Bash is divided between his work at the hospital and a patient he is helping to treat remotely in Syria. Dr. Bishop puts extra pressure on Bash, while Theo feels powerless when something happens to one of his daughters back home. Meanwhile, a patient puts Mags’ moral convictions to the test, and June tries to improve her social skills.

Bash finds himself connecting with an unlikely patient, while Mags strives to find balance in her life. Theo has a difficult discussion with his wife, Melissa. June attempts to connect with a closed-off teenage patient and Claire take care of a couple checking things off their bucket list.

As Bash fights for Dr. Bishop's legacy, big questions about his own future are finally answered.

Bash treats a woman whose ketamine therapy goes awry; Mags loses confidence in her new boss; June realizes she has too much on her plate; Theo reunites with a young former patient whose life may depend on the death of another patient.

Bash finds himself at odds with his direct supervisor while they treat a couple of skydivers with a unique relationship; Mags speaks out against her supervising doctor; a mistake comes back to bite Theo.

Recovering from a personal crisis, Mags worries about how to get her life back on track; Bash takes an unorthodox approach to treating a soldier with PTSD; Theo treats a terminally ill child whose father is desperate for a drug trial.

Bash and Mags fall into friendly competition at work, and a man with superhero ideation crash lands into the Emergency Department. June tries group therapy, and Theo faces a tribunal to decide his fate.

When Bash and Mags work together to treat a patient with a tricky diagnosis, Mags realizes that Bash’s experience as a doctor in Syria has led to an instinct-based approach. Head nurse Claire Malone is concerned that Dr. Bishop is already working following his accident. June struggles to put her foot down with Dr. Singh concerning the needs of a patient, and Theo works to build a connection with Bash.

Bash does his best to celebrate Eid with his sister Amira, but she wishes they could continue the traditions they had back home. At the hospital, Bash has difficulty respecting a patient’s decision, while Mags tries to gather all the information they need to save a gunshot victim. Theo treats a teenage patient who wants to avoid telling his parents why he’s in the hospital.

Bash provides medical care to a friend who is reluctant about treatment, while Mags has her hands full with a young woman who seems to be withholding information. Dr. Bishop offers Mags an incredible opportunity, and someone from June’s past tries to reach out to her. Faced with a young athlete without a clear diagnosis, Theo also has to navigate the patient’s complicated family dynamic.

When a young mother addicted to opioids nearly dies, Bash must figure out whether she's using again, or if something else is causing her deadly symptoms. Mags tries to help a patient who isn't healing properly, while June is blindsided by her father.

Bash faces an important figure from his past and must solve a public health crisis; hospital administration calls Devi's leadership into question; Mags doubts all of her choices; June is asked to oversee a sensitive procedure.

Bash and Mags team up to save a John and Jane Doe found in the woods. A fully qualified surgeon now, June sees her old mentor in a new light. Suspended from the hospital, Theo longs for the action while treating patients virtually. Devi makes a budget cut decision, which will have major consequences for the Emergency Department.