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The Best Episodes of Grey's Anatomy

Every episode of Grey's Anatomy ranked from best to worst. Let's dive into the Best Episodes of Grey's Anatomy!

Follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital.


Top Episode Highlight

The best episode of "Grey's Anatomy" is "Sanctuary", rated 9.7/10 from 3612 user votes. It was directed by Stephen Cragg and written by Shonda Rhimes. "Sanctuary" aired on 5/20/2010 and is rated 0.0 point(s) higher than the second highest rated, "Death and All His Friends".

  • Sanctuary
    9.7/10 3,612 votes

    #1 - Sanctuary

    Season 6 Episode 23 - Aired 2010-05-20

    Seattle Grace Hospital is hit with a crisis like no other in its' history.

    Director: Stephen Cragg

    Writer: Shonda Rhimes

  • Death and All His Friends
    9.7/10 4,021 votes

    #2 - Death and All His Friends

    Season 6 Episode 24 - Aired 2010-05-20

    Cristina and Meredith's surgical skills are put to the ultimate test.

    Director: Rob Corn

    Writer: Shonda Rhimes

  • Now or Never
    9.5/10 3,041 votes

    #3 - Now or Never

    Season 5 Episode 24 - Aired 2009-05-14

    In the second part of the two hour season finale, George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and Izzie's friends anxiously await her recovery from surgery. Meanwhile Bailey is surprisingly displeased after being accepted into the pediatric fellowship program, and the victim of a near-fatal traffic accident brings the talents of Seattle Grace's doctors together. This is the second hour of a 2-hour season finale.

    Director: Bill D'Elia, Rob Corn

    Writer: Debora Cahn, Allan Heinberg

  • Silent All These Years
    9.5/10 2,940 votes

    #4 - Silent All These Years

    Season 15 Episode 19 - Aired 2019-03-28

    When a trauma patient arrives at Grey Sloan, it forces Jo to confront her past. Meanwhile, Bailey and Ben have to talk to Tuck about dating.

    Director: Debbie Allen

    Writer: Elisabeth R. Finch

  • It's the End of the World
    9.4/10 3,164 votes

    #5 - It's the End of the World

    Season 2 Episode 16 - Aired 2006-02-05

    An explosive case arrives at the O.R. that might endanger all the lives of the people working there, which leads Dr. Burke to declare a "Code Black" for the hospital. Bailey worries where her husband is as she is in labor. Also Izzie and Alex may be creating some heat.

    Director: Peter Horton

    Writer: Shonda Rhimes

  • As We Know It
    9.4/10 3,076 votes

    #6 - As We Know It

    Season 2 Episode 17 - Aired 2006-02-12

    Derek is still operating when he finds out about Meredith's current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and Izzie have their own issues to deal with because of Meredith's situation. Addison freaks out when George tries to find a solution to Bailey's impromtu postponement. Overall, Seattle Grace Hospital is still under code black and the situation is getting worse.

    Director: Peter Horton

    Writer: Shonda Rhimes

  • Losing My Religion
    9.3/10 2,528 votes

    #7 - Losing My Religion

    Season 2 Episode 27 - Aired 2006-05-15

    This episode is the second part of a two-hour season finale. Richard tries to get information from Addison about a family member's condition. Callie and George have a talk about his feelings. Meredith and Derek have a talk about Doc.

    Director: Mark Tinker

    Writer: Shonda Rhimes

  • Fear (of the Unknown)
    9.2/10 1,954 votes

    #8 - Fear (of the Unknown)

    Season 10 Episode 24 - Aired 2014-05-15

    The doctors of Grey Sloan Memorial Hospital bid an emotional farewell to the beloved Cristina Yang. A possible act of terrorism rocks Seattle and causes chaos at the hospital. Meanwhile, Meredith makes a life changing decision and one doctor receives shocking news.

    Director: Tony Phelan

    Writer: Shonda Rhimes

  • The Sound of Silence
    9.2/10 2,346 votes

    #9 - The Sound of Silence

    Season 12 Episode 9 - Aired 2016-02-11

    Meredith is brutally attacked by a patient, and Penny is the one who discovers her. The doctors of Grey Sloan Memorial rush to stabilize Meredith and remain by her side in the harrowing aftermath.

    Director: Denzel Washington

    Writer: Stacy McKee

  • What a Difference a Day Makes
    9.1/10 1,926 votes

    #10 - What a Difference a Day Makes

    Season 5 Episode 22 - Aired 2009-05-07

    As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.

    Director: Rob Corn

    Writer: Shonda Rhimes

  • Dark Was the Night
    9.1/10 1,775 votes

    #11 - Dark Was the Night

    Season 8 Episode 9 - Aired 2011-11-10

    Teddy puts her husband’s life in the hands of her peers when Henry is sent to the OR for surgery and she’s called away on another case; Meredith and Derek receive the long-awaited news about Zola; Callie and Jackson come under fire when their patient experiences post-surgery complications; and Meredith and Alex are involved in a life-threatening situation when they travel to a neighboring hospital to tend to a sick newborn, on Grey’s Anatomy

    Director: Allison Liddi-Brown

    Writer: Debora Cahn

  • Who Lives, Who Dies, Who Tells Your Story
    9.1/10 1,970 votes

    #12 - Who Lives, Who Dies, Who Tells Your Story

    Season 14 Episode 7 - Aired 2017-11-09

    After a roller coaster car falls off the track at the county fair, the doctors at Grey Sloan tend to patients who spark memories about ghosts from their past. The series 300th episode!

    Director: Debbie Allen

    Writer: Krista Vernoff

  • Into You Like a Train
    9.0/10 2,187 votes

    #13 - Into You Like a Train

    Season 2 Episode 6 - Aired 2005-10-30

    Train Wreck victims come to Seattle Grace and all staff gets called in. Everyone deals with really weird cases. Except Addison and Izzie. They work with a woman who is pregnant.

    Director: Jeff Melman

    Writer: Krista Vernoff

  • 17 Seconds
    9.0/10 1,914 votes

    #14 - 17 Seconds

    Season 2 Episode 25 - Aired 2006-05-14

    George and Derek work together, Denny still doesn't have a heart, and Meredith gets paired with Callie. A 12-week pregnant girl dies in the O.R. and her parents try to keep the baby alive. This causes tension between Derek and Addison. One doctor's overreaction unites two bickering patients. Finn is still treating Doc for medical problems.

    Director: Daniel Minahan

    Writer: Mark Wilding

  • Deterioration of the Fight or Flight Response
    9.0/10 1,918 votes

    #15 - Deterioration of the Fight or Flight Response

    Season 2 Episode 26 - Aired 2006-05-15

    Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot. Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke.

    Director: Rob Corn

    Writer: Joan Rater

  • Drowning on Dry Land
    9.0/10 1,838 votes

    #16 - Drowning on Dry Land

    Season 3 Episode 16 - Aired 2007-02-15

    Meredith is still underwater, but nobody seems to notice. Her worsening condition makes her rescuing an urgent matter. Derek finds her coat on a man she had helped, and starts looking for her and, much to his shock, the little girl Meredith took care of suggests that she is in the water. Derek saves her, but she is almost dead, due to hypothermia. Izzie has to perform brain surgery on a man stuck between cars, as he begins to experience seizures. She drills holes into his head, perforates his skull and ultimately saves his life before he is rescued and transferred to Seattle Grace Hospital. George lies to the woman whose son he had been looking for, in order to get to surgery, but still doesn't have any luck in locating him. Alex finds no hope in searching for the pregnant Jane Doe's family as she undergoes surgery. The interns find out about Meredith's situation and express their hopelessness. She wakes up in what appears to be limbo and meets her deceased acquaintances.

    Director: Rob Corn

    Writer: Shonda Rhimes

  • Stairway to Heaven
    9.0/10 1,812 votes

    #17 - Stairway to Heaven

    Season 5 Episode 13 - Aired 2009-01-22

    Bailey grows desperate as a patient's condition becomes more and more dire. Everyone in the hospital is stepping up to try to find the boy a new organ donor, including Meredith, who considers a death row patient's wish to die before execution. Meanwhile, an injury leaves Mark in a compromising position in the OR and Cristina awkwardly avoids Owen.

    Director: Allison Liddi-Brown

    Writer: Mark Wilding

  • I Saw What I Saw
    9.0/10 1,940 votes

    #18 - I Saw What I Saw

    Season 6 Episode 6 - Aired 2009-10-22

    After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace resident defends their actions in an effort to save their jobs.

    Director: Allison Liddi-Brown

    Writer: William Harper

  • Suddenly
    9.0/10 1,604 votes

    #19 - Suddenly

    Season 8 Episode 10 - Aired 2012-01-05

    A severe car crash involving an entire family results in an all-hands-on situation in the ER, as the eldest daughter is left to make the toughest decision of her life. Meanwhile Teddy, still in the dark about Henry's death, calls upon Cristina to help with her patient in the O.R., and Lexie finds herself working alongside Mark's new girlfriend, Julia, during an eye surgery.

    Director: Ron Underwood

    Writer: Stacy McKee

  • Elevator Love Letter
    8.9/10 1,622 votes

    #20 - Elevator Love Letter

    Season 5 Episode 19 - Aired 2009-03-26

    All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.

    Director: Edward Ornelas

    Writer: Stacy McKee

  • Perfect Storm
    8.9/10 1,512 votes

    #21 - Perfect Storm

    Season 9 Episode 24 - Aired 2013-05-16

    Grey Sloan Memorial Hospital enters crisis mode as the storm rages, resources become scarce and patients flood in by the busload. Meanwhile, one of the doctors fights for their life.

    Director: Rob Corn

    Writer: Stacy McKee

  • The Distance
    8.9/10 1,525 votes

    #22 - The Distance

    Season 11 Episode 14 - Aired 2015-03-05

    In this Amelia-centric episode, Amelia engages in the surgery of a lifetime as a crowd of doctors look on from the gallery. With Stephanie by her side, she begins operating on Dr. Herman, but quickly realizes it's far more difficult than she anticipated. Meanwhile, Bailey becomes skeptical when Arizona takes on one of Herman’s cases.

    Director: Eric Laneuville

    Writer: Austin Guzman

  • Guess Who's Coming to Dinner?
    8.9/10 1,641 votes

    #23 - Guess Who's Coming to Dinner?

    Season 12 Episode 5 - Aired 2015-10-22

    In the midst of the sisters’ dinner party, Maggie ditches her cooking duties to rush to the hospital. Meanwhile, April steps in to help cook as an attempt to avoid Jackson, and Arizona nervously waits to find out more about Callie’s new girlfriend.

    Director: Debbie Allen

    Writer: Meg Marinis

  • My Shot
    8.9/10 1,340 votes

    #24 - My Shot

    Season 16 Episode 8 - Aired 2019-11-14

    Meredith faces the medical board as her future as a doctor remains uncertain, and she’s forced to reckon with her past in some challenging ways. Meanwhile, the interns are put to the test as they are each vying to be the most successful on their respective cases in the absence of some of the attendings.

    Director: Debbie Allen

    Writer: Meg Marinis

  • Walk on Water
    8.8/10 1,690 votes

    #25 - Walk on Water

    Season 3 Episode 15 - Aired 2007-02-08

    A mass trauma situation, which turns out to be a ferryboat accident, challenges the whole staff of Seattle Grace Hospital. Richard finds difficulty in coping with his separation from his wife and dyes his hair "for the ladies", which becomes an internal joke between Mark, Burke and Derek. Cristina tries to tell Meredith about her upcoming marriage, but doesn't have the strength to. George promises to find a woman's son, who has been separated from her at the accident. The woman refuses to go into surgery until she is assured that her son is alive. Izzie has to take care of a man who got stuck between two cars on the ferry, but nobody helps her due to the large number of injured people. Alex rescues a pregnant woman with severe wounds on her face, and promises to take care of her. Meredith looks after a girl who has been separated from her mother after the accident, but accidentally falls into the water and drowns, with nobody but the little girl as a witness.

    Director: Rob Corn

    Writer: Shonda Rhimes