Tara re-emerges but the task now is to repair broken family relationships, particularly with Marshall who is fed up with it all. Rather than go into a local mental health facility, she decides to follow Dr. Hatteras' advice and see a specialist in Boston. Neil and Charmaine are moving to Houston and offer to take Marshall with them. Kate receives an offer to move to St. Louis. As a new family dynamic emerges, everyone contemplates and wonders what the future may hold.

Her psychology professor humiliates Tara when she transitions in his class. Meanwhile, Kate considers giving English lessons in Japan and Max gets a business offer.

Tara and Charmaine are rushed to the hospital in the same ambulance, where Charmaine declares her baby off limits to her crazy sister; Tara attempts to make a deal with her alters, which intrigues her Abnormal Psychology professor; Marshall, Lionel and Noah put Charmaine's empty house to some creative uses; Kate is embarrassed to confess that she backed out of going to Japan.

Tara tries to drop her Abnormal Psychology class but instead receives an intriguing pitch from her instructor, Dr. Hattaras; Charmaine and Neil find parenthood a struggle but still refuse Tara's help; Max finds himself at odds with his boss at his new job; Kate prepares for flight attendant training; Lionel catches Marshall with Noah, jeopardizing their student film project.

Max and Marshall return home from New York to bad news on all sides. Max learns of the new alter, Bryce, but a highly medicated Tara assures him all in under control. Marshall learns that a close friend has been killed in an accident. Tara offers support, which he gladly accepts, but on the day of the funeral Bryce emerges and apparently will not go away. It's all too much for Kate and Marshall who look to strike out on their own.

Needing a break from real life, Kate and Tara head out on an impromptu road trip. Max uses this time away from Tara to search for answers about her past. That night, Tara and Kate get into an argument causing Tara to transition into “T.” “T” heads to the nearest tattoo parlor and Kate tries to stop her before she makes a permanent mistake.

Tara decides to check into an in-patient facility that specializes in dissociation. There, Tara meets a new doctor, Dr. Holden, a charismatic expert, who pushes her to recover lost memories. The facility has support groups for significant others too, but Max is wary. As Tara tries hard to delve into her past, her alters are resistant to allowing the truth to surface, and Max learns he’ll have to be stronger than ever to help Tara take the next step in her recovery.

Max is worried when Tara returns to college to finish her college degree. Meanwhile, Charmaine with a baby on the way is avoiding a commitment to Neil, Kate tries to figure out a plan for her future and Marshall and Lionel sign up for a filmmaking class.

With Max and Dr. Holden’s help, Tara meets face-to-face with an important person from her past. This meeting, while difficult, leaves Tara feeling conciliatory and expansive. Marshall finally reconciles with Tara and gives her his full support. The family, now reunited for the first time since Tara checked into the hospital, decides to partake in a family tradition – bowling but as Tara looks around at her family, she realizes she’s not who she is in spite of her alters, but BECAUSE of them.

Tara and Charmaine discuss Tara's childhood memories with their mother and Max holds an open house after re-modeling their neighbor's house.

Tara and Charmaine pay a woman who appeared in Tara's memories a visit, while Kate tries to change herself for her new and much older boyfriend.

The stress of juggling school and Charmaine's baby shower causes Tara to transition, with negative consequences for Charmaine. To sell the family business, Max must get the approval of his eccentric mother. Kate meets a flight attendant who inspires a new idea about her future.

The discovery of Tara's new dangerous alter makes Dr. Hattaras and Tara consult another professional. Marshall finds out that his short film hurt his father's feelings and Charmaine connects with "chic moms," while Kate tries to make her relationship with Evan work.

The family is under the impression that Tara’s parents, Bev and Frank, are visiting to celebrate Charmaine’s birthday but when Frank approaches Max about taking the kids to live with them, Max does everything he can to prevent Tara from switching. At the party that night, Tara learns of her parents’ plan and is hurt that they think she is an unfit parent. Sweeping her feelings under the rug, she remains calm however, later that evening, Max wakes to find something that changes everything.

When Bryce takes over, Tara's new alter threatens to destroy the whole family. When Tara's other alters disappear one by one, Max decides to fight off Bryce before it's too late for Tara.

Tara motivates Max to relive his old rock band Beaverlamp. Meanwhile, a depressed Dr. Hattaras makes her take a break from their therapy sessions and Marshall and Noah interview Max for their film festival project.

Charmaine has decided to get her breasts re-done and has asked Tara to be her caretaker while she recovers. Kate gives Marshall Love advice, telling him to play hard to get with Jason. When Charmaine wakes after her surgery, she is surprised to see “Buck” at her bedside, not Tara. While “Buck” takes care of Charmaine, she comes to appreciate him in a way she never has before.

Max has his hands full while “Alice” is out again. Marshall fears Jason’s father knows about his crush on Jason. The boys grow closer, albeit platonically. Max decides to embrace his time with “Alice,” even though he misses his wife.

Tara feels like a failure as a mother when she is unable to counsel her children about school and sex, so she turns to her perfect-homemaker personality "Alice" for help.

When Tara and Max can’t connect in the bedroom, Tara worries Max may be more interested in her alters than her. After gaining reassurance from her therapist Dr. Ocean,Tara plans a “sex date” with Max to get them back on track. Tara’s sister Charmaine recommends she meet her new boss for a potential mural project. As Tara prepares for her “sex date” with Max, the pressure becomes too much and she becomes “Buck.” That night, “Buck” doles out advice on women and Max ends up male-bonding with his own wife.

Tara turns into “T” and takes off in her car. Max and Charmaine go after her, creating the perfect opportunity for Marshall to throw a party as an excuse to be near his crush, Jason. Charmaine, Max, and “T” all return to the house to discover a raging party going on -- the buzz gets killed in more ways than one.

Tara seems to be making progress with her new contract but Dr. Hattaras discovers something disturbing in a tape from one her therapy sessions; much to the sisters' chagrin, Neil invites Tara and Charmaine's mother to visit her grandchild; Max is unhappy at his new job but can't talk to Tara about it; Kate is surprised when a handsome flyer rebuffs her flirting.

A new alter comes to light that put Charmaine's new baby at risk. Soon later, Alice visits Dr. Hattaras and intrigues him in Tara's case again. Kate, Max and Marshall fly to New York where they get to meet Kate's new friend Evan and his son.

A tornado brings some long-covered secrets to light when Tara's alter Shoshana takes over.

Season two opens with a bang as the Gregsons' neighbor commits suicide and the family unexpectedly is given responsibility of the house. Now well and dissociation-free for several months, Tara sets out to make new friends with Max's help. Marshall struggles to fit in at school while Kate lands a new job. Nick pops the question to Charmaine