Drake has taken advantage of Josh for the last time and Josh decides that he is done dealing with Drake. Drake says he's fine with this, but when Josh's life improves and Drake's goes down the drain this rocker begins crooning a different tune.

It's the end of an era. After Josh ruins Drake's chances at having a hit song in the Superbowl, the boys must find a way to make things right.

Josh is confident about when Walter chooses him to be his co-weatherman. That is, until Megan reminds Josh of his uncontrolable twitch. So Josh twitches in front of the whole world and becomes the laughing stock of San Diego. Meanwhile, Drake is determined to win the talent show for the third year in a row but finds it challenging when he rivals with an acappella group.

Drake teases Josh that he can't get girls. So, Drake and Josh make a bet to see how many girls each of them can date in just one week. The rules are, every date must last at least one hour, you can't date someone you already know, and you can't date the same person twice.

After the boys get in trouble for using Fake ID's Audrey and Walter fear they will fall to a life of crime and sign them up for a “Steered Straight” program, but things start skidding out-of-control when a real criminal befriends them.

A new roller coaster is coming out called, the Demonator. Drake and Josh want to be there the first day it opens. But when they get in line, their wild adventure starts.

It's the end of an era. After Josh ruins Drake's chances at having a hit song in the Superbowl, the boys must find a way to make things right.

The whole gang has gathered at Drake and Josh's house before Drake's big concert, but thanks to Walter's poor weather predictions they end up stuck in the house due to severe rain. Sure, it's raining outside, but the real storm for Drake to weather is when his new girlfriend meets his exes.

Drake, Josh, and Megan must rebuild a tree house that they accidentally destroyed

Josh decides to enter a local dance contest, but when Drake realizes he's going to fail gym, he has to enter in order to receive high school credit. So he steals Josh's dance partner, and that's when things start to go wrong.

Drake and Josh make a bet to swear off junk food (Drake) and Video Games (Josh). Megan makes both of them swear to dye their hair pink (whoever loses). When Drake and Josh's mom and dad discover them making a bet, they make a bet as well. When things get crazy, Drake and Josh can't hold onto their bet much longer and decide to break it.

After accidentally punching Drake in school, Eric becomes very popular. Meanwhile, Josh thinks that Mindy has a new boyfriend.

The most popular kid in school is throwing what may be the greatest sixteenth party ever, but Drake and Josh may be having cake for two after they get banned from the party.

Drake is so excited when Megan wins a radio contest, and the prize is tickets to the Zero Gravity concert and a guitar signed by Devan Malone, the head guitarist of Zero Gravity. The best part is, Megan lets Drake have the prize! Drake is so obsessed with this guitar. When Josh accidentally sets the guitar on fire, he must come up with a way to replace it before Drake becomes insane forever. Meanwhile, Walter tries to spend quality time with Drake, but everytime Walter tries to go for it, Drake is doing something important.

Josh is jazzed at the prospect of meeting his TV idol when Drake gets tickets to “Oprah” for his birthday, but delight turns to dismay in the studio parking lot.

Mindy tells Josh that she loves him and Josh slams the door in her face and runs to Drake, but Drake tells Josh that she is just trying to distract him so she can win the Science Fair.

Drake and Josh accidentally kill Megan's hamster and they think she is planning revenge.

When Audrey and Walter go out of town for spring break they leave Drake, Josh, and Megan at home by themselves. When they are at the Premiere they overhear a couple saying that they don't have a place to stay. Drake and Josh take advantage of this opportunity and say that their vacant house is a hotel. Meanwhile, Megan is attempting to get Drake and Josh to treat her like a guest.

When Drake and Josh remember they got in a fight several years ago at a San Diego Padres game, they realize they fought each other. Then they spend the next few days fighting over who started the fight.

Megan's been extremely secretive and Drake and Josh investigate to find out what she's up to. The clues lead to a new boyfriend and all seems wonderful until they find out Megan's new beau may be trouble.

Drake wins a free skydive off a helicopter and sets off to do it despite his parents' wishes. Josh, being the good brother he is, tries to stop him, but ends up going along for the ride. This fun time in the sky becomes a true downer when they accidentally lose their pilot and things start spinning out of control.

Drake finds out Josh is great at pool or billiards as Josh calls it. Drake bets some kids, and takes advantage of Josh's pool skills and starts hustling people, by taking their money, shoes and other clothing/personal items. Now Josh has made the ultimate bet, and Drake's stuffed in the corner pocket.

Drake is accused of parking Mrs. Hafer's car in the middle of her classroom. Drake and Josh must go in front of the school's Honor Council to prove Drake is innocent.

Mindy invites Josh over to her house for dinner and to meet her parents, but things don't go well. Josh hosts another dinner at his house to try and impress Mindy's parents to make up for last time. He asks Drake to not mess up his date. Meanwhile Drake and his new girlfriend, Lucy, wrestle to see who is tougher, to prove that some girls are tougher than boys.

Drake and Josh decide to turn the tables and prank little Megan. She actually believes that aliens are coming down to Earth and they are going to kidnap her. But at the end, Drake and Josh find that this may not go as they hoped.