Friends and comedians Jay Larson and Sean Patton explore bars featured in Esquire magazine’s annual rundown of the best in the country with stops in Milwaukee, Chicago and San Francisco.

Jay and Sean visit Portland, Oregon, a town known for its alternative ethos and hipster spirit. From a microbrewery and a small batch whiskey bar to a rum club and a spot for an authentic Spanish coffee, the guys take in the city’s artisanal culture, jump on an old-timey bar bus tour, and check out the town’s oldest strip club. Special guest: The Decemberists’ Chris Funk.

Jay and Sean visit Austin, Texas, a town that embraces the craft cocktail movement while giving it a unique local twist and a dash of downhome Texas charm.

Jay and Sean visit New York City, where they meet the creator of Esquire magazine's annual best bars list and follow his advice to find the best watering holes in the Big Apple.

Jay and Sean visit Jay's hometown of Boston, and create a whirlwind tour of Beantown.

Jay and Sean search for the best hotel bars in the U.S. Comedians Nick Thune and Jen Kirkman appear.

Jay and Sean travel the country looking for that which is often overlooked, the best hotel bars in the country. Special guests include comedians Nick Thune and Jen Kirkman.

More than just sleazy neighborhood dumps, Jay and Sean hunt for the best dive bars America has to offer.

Jay and Sean visit New Orleans, Louisiana, the birthplace of both jazz and Sean Patton.

Jay and Sean end their cross-country journey back home in Los Angeles; guests include comic Rory Scovel, chef Roy Choi and musician Matt Sorum.

Season 2 begins with comedians Jay Larson and Sean Patton getting punch drunk with Nat Faxon in San Francisco.

Jay and Sean visit Washington, D.C., and drink from the country's largest whiskey collection, check out a new brewery in the old Navy yard and make booze the colonial way in the home of America's first president.

Jay and Sean visit Louisville and learn there is a lot more than whiskey in bourbon country. They sip a cocktail with a haunted history, go nose-to-tail with char-grilled squirrel, and learn a palate-busting beer lesson from the Brew Dogs.

Jay and Sean take in the booze-cruising, polka-filled world of Minneapolis, where they snack on pig's head, enter meat raffles and compete in a home brew-themed curling tournament.

Jay and Sean walk through armoires, sneak in back doors and slide away bookcases to reveal the Cuban flair, coin tricks and innovative cocktails of the modern and well-hidden speakeasy. Aisha Tyler appears.

Jay and Sean visit the Southern California coast, where they find an old stagecoach stop in the mountains of Santa Barbara, a pop-up culinary cocktail bar in a Venice garden and a beach-front dive with ice cold beer. Comedian Bill Burr appears.

Jay and Sean search for the best bar food in America. In San Francisco, they toss dough with a champion pizza maker. In Chicago, they learn the true meaning of going "whole hog"; and in Los Angeles they nearly drown in nacho cheese with comedian Al Madrigal.

Jay and Sean visit Chicago and learn about booze's mobster roots. They get the Picasso treatment at a neighborhood landmark, take in the comedy scene with Pete Holmes, and get a taste of local music with blues legend Buddy Guy.

Jay and Sean visit Detroit, which was named Esquire's Bar City of the Year, and drink at a train station turned craft beer hub. They also take part in a spirits tasting straight out of the history books and go on a city-wide bike ride with hundreds of new friends.

Season 2 ends with Jay and Sean playing bingo, beer pong and virtual golf at the best game bars in the country. They also get heckled at a renaissance fair, test their smarts with comedian Kyle Kinane and strike out with swimsuit model Nina Agdal.