Season 2 begins with comedians Jay Larson and Sean Patton getting punch drunk with Nat Faxon in San Francisco.

Jay and Sean visit Washington, D.C., and drink from the country's largest whiskey collection, check out a new brewery in the old Navy yard and make booze the colonial way in the home of America's first president.

Jay and Sean visit Louisville and learn there is a lot more than whiskey in bourbon country. They sip a cocktail with a haunted history, go nose-to-tail with char-grilled squirrel, and learn a palate-busting beer lesson from the Brew Dogs.

Jay and Sean take in the booze-cruising, polka-filled world of Minneapolis, where they snack on pig's head, enter meat raffles and compete in a home brew-themed curling tournament.

Jay and Sean walk through armoires, sneak in back doors and slide away bookcases to reveal the Cuban flair, coin tricks and innovative cocktails of the modern and well-hidden speakeasy. Aisha Tyler appears.

Jay and Sean visit the Southern California coast, where they find an old stagecoach stop in the mountains of Santa Barbara, a pop-up culinary cocktail bar in a Venice garden and a beach-front dive with ice cold beer. Comedian Bill Burr appears.

Jay and Sean search for the best bar food in America. In San Francisco, they toss dough with a champion pizza maker. In Chicago, they learn the true meaning of going "whole hog"; and in Los Angeles they nearly drown in nacho cheese with comedian Al Madrigal.

Jay and Sean visit Chicago and learn about booze's mobster roots. They get the Picasso treatment at a neighborhood landmark, take in the comedy scene with Pete Holmes, and get a taste of local music with blues legend Buddy Guy.

Jay and Sean visit Detroit, which was named Esquire's Bar City of the Year, and drink at a train station turned craft beer hub. They also take part in a spirits tasting straight out of the history books and go on a city-wide bike ride with hundreds of new friends.

Season 2 ends with Jay and Sean playing bingo, beer pong and virtual golf at the best game bars in the country. They also get heckled at a renaissance fair, test their smarts with comedian Kyle Kinane and strike out with swimsuit model Nina Agdal.