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Brilliant Minds S2E5 — Once Upon a Time in America

8.1

Brilliant Minds•Season 2•Episode 5

Once Upon a Time in America

8.1/10 · 238 votesOct 20, 202543 min

Ranked #7 of 20 in Season 2•matches the season avg

When two patients arrive in critical condition, Dr. Wolf and Dr. Nichols must do whatever it takes to keep them alive.

Directed byParis Barclay

Written byStasia Demick, Shannon Looney

Previous episodeE4 · Lady Liberty Next episodeE6 · The Doctor's Graveyard

Seasons2

Cast8

Zachary Quinto

Zachary Quinto

Oliver Wolf

Tamberla Perry

Tamberla Perry

Carol Pierce

Ashleigh LaThrop

Ashleigh LaThrop

Ericka Kinney

Aury Krebs

Aury Krebs

Dana Dang

Teddy Sears

Teddy Sears

Josh Nichols

Brian Altemus

Brian Altemus

Charlie Porter

John Clarence Stewart

John Clarence Stewart

Anthony Thorne

Al Calderon

Al Calderon

Scotty Silva

Crew5

S

Stasia Demick

Writer

S

Shannon Looney

Writer

Paris Barclay

Paris Barclay

Director

G

Gaston Jaren Lopez

Editor

S

Stanley Fernandez Jr.

Director of Photography

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Episode Summary

"Once Upon a Time in America" is episode 5 of Brilliant Minds season 2. It scored 8.1/10 from 238 votes, ranking #7 of 20 episodes this season (season average 8.1). Directed by Paris Barclay and written by Stasia Demick, Shannon Looney, it aired on October 20, 2025.

Next: E6 · The Doctor's Graveyard Best of Season 2