Working as a 999 call handler helps Iain learn to open up, though he feels frustrated not to be out in the field.

Iain's mistake with a patient has serious repercussions, putting many lives in danger.

Feature-length episode of the hospital drama with the staff of Holby's accident and emergency department as they deal with more sick and injured patients. The walls start to close in on Connie when the hospital board notices the high rate of benzodiazepine prescriptions in the emergency department, and she is forced to choose between her addiction and her career. Meanwhile, Iain takes a stand as he defends the paramedics in the emergency department, and Duffy learns that she does not need to be a nurse to be able to help others.

Dylan faces a traumatic Christmas in Resus. Noel is delighted to have met his Christmas fundraising goal, but can't quite decide on a charity to give the money to.

A cyber-attack rocks Holby hospital at the worst possible time. Meanwhile, Ruby learns to trust her instincts as Iain’s life hangs in the balance.

Jan learns the truth about her son and forgives Iain, while Ethan begins to move on from Alicia. Louise stands up for Jade and vows to protect her team in the future, Duffy panics when she forgets that she bought Charlie a birthday present, and Iain signs up for his first counselling session.

Determined to learn from medics in other departments, Louise is excited for a shift on the maternity ward. However, student nurse Jade stumbles into work late, and Louise is not impressed by her actions. Meanwhile, Charlie remains suspicious of Duffy, and Iain makes a call to the wellbeing team, finally seeking help about his mental-health struggles.

Archie butts heads with charming paediatric locum registrar Will Noble when they meet in the car park. Will reconnects with old university friend Ethan and ingratiates himself with the staff by treating them to coffees and getting to know them. Archie is not fooled by his charm offensive and keeps a close eye on Will. Elsewhere, Jade learns she's passed her exams by the skin of her teeth, and Gem thanks Jan and Ruby for their help.

Marty plays counsellor for a couple who having problems with their relationship. After a busy and fulfilling day - treating patients including a girl involved in a hit and run accident, and two women who are attacked in a nightclub - Iain feels that his work with Ruby is done. Elsewhere, Dylan sees maggots cleaning a wound and gets an idea, and Ruby moves in with Jade and Marty.

Duffy makes the tough decision to hang up her uniform. Jacob discovers a truth from his past. Connie is furious with Ciaran when she finds out that Duffy has stepped down.

Bill is admitted to the emergency department suffering from chest pains. Charlie agrees to help him find out if his daughter is still drinking, but ends up discovering his affair with Duffy. A teenager is brought in after having been apprehended by the police, and while Ethan wants to discharge her as soon as possible, Alicia suspects her case may be more complicated. Marty tries to arrange a date with Joshua - but they may end up having some company.

Iain learns to put patients first without compromising his mental health. Jade is gutted when she discovers Marty has won the bursary, until she hears about all the obstacles he has overcome to get to where he is. Gem considers joining Rash on his travels, but decides to stay for Iain's sake.

Iain gets beaten up, and Marty chooses his career over friendship with Jade.

The aftermath of Iain's attempted suicide ripples its way through the emergency department. Gemma struggles to come to terms with what has happened, and makes it her mission to piece together why Ian attempted suicide. Meanwhile, wracked with guilt, Ruby goes out of her way for a patient, and Connie tells Elle off for addressing the team about Iain's progress.

After a hard day, Iain seeks comfort in the wrong place. Duffy makes a shocking diagnosis

Connie takes the opportunity to prove herself, but it ends in disaster. Duffy proves her worth in the ED but gets caught in the middle of Connie's mistake.

Ciara comes back into Dylan's life, while the fallout from the crash affects the whole department.

After recent traumatic events, how will Alicia cope with returning to work earlier than expected?

Dylan puts himself and Ciara in jeopardy when he takes a chance on love, while student nurse Marty (former EastEnders star Shaheen Jafargholi) arrives at the ED on his first day eager to please. Louise witnesses an elderly man being robbed by a gang of youths on bicycles, but soon learns not to judge a book by its cover. Elsewhere, Iain gets the runaround when asking for help, and Duffy catches Charlie answering her phone.

Will faces the biggest medical dilemma of his career when Toby returns to the ED. Ruby continues to keep Dani a secret, allowing her to get even closer. Charlie and Duffy renew their vows, and Marty returns to the ED from secondment to find Jade miffed that he didn’t keep in touch

Zsa Zsa returns to save Dylan, but can even she help him? Rash reels from his break-up with Gem.

It is judgement day for the ED, as the inspectors descend. Dylan has to face Ciara. Louise's management style frustrates the nursing team.

In the aftermath of the crash, Ciara is desperate to get away, but Dylan is determined to treat those who have been injured - despite receiving a head wound himself. On his return to the hospital, he reflects on his hopes for a future with Ciara in spite of everything that has happened, while at home, Ciara considers her own needs.

Iain heads to Base's flat, but when he does not answer the door he becomes concerned and climbs through a window, only to find Base has taken an overdose. Louise goes out of her way for Ernest when he comes to the ED for a once-over, while Gem and Ruby look for somewhere new to live when Alicia's house goes on the market.

Duffy finally lets Charlie in on her big secret and tells him about her Vascular dementia diagnosis. Charlie decides that it may be best to pull her from the night shifts, when symptoms are most likely to appear. Meanwhile, new registrar Archie Hudson is thrown into the deep end on her first day after leaving her hospital induction early, and Connie reluctantly praises Elle's success.