A family of victims from a house fire are rushed to Gaffney. Lenox fights to save two sisters injured in an all-night rave turned tragedy. Tensions mount between Goodwin and Abrams over difficult staffing changes.

Things get personal when Ripley and Archer butt heads over the treatment plans tied to an unusual case, and a crisis at a nearby condominium brings an influx of patients. Meanwhile, Asher makes a surprising discovery with an expectant couple, a patient throws the hospital into chaos, and some familiar faces return to Gaffney.