A family of victims from a house fire is rushed to Gaffney. Lenox fights to save two sisters injured in an all-night rave turned tragedy. Tensions mount between Goodwin and Abrams over difficult staffing changes.

Things get personal when Ripley and Archer butt heads over an unusual case. Asher makes a surprising discovery with an expectant couple. A patient throws the hospital into chaos.

Lenox and Frost receive an unusual request from the parents of a patient on life support. Ripley and Charles work with a man who can't remember who he is.

Charles races to convince a patient to accept treatment before it's too late. Frost bonds with a young girl battling immunodeficiency. Lenox makes a chilling discovery.

A personal clash between Asher and Archer reaches a breaking point. Charles and Ripley uncover a rare neurological disorder in a patient. Goodwin's personal life is put to the test.