After a baby is abducted from Med, Goodwin enlists the help of Dr. Charles and Dr. Reese to find the suspect. Due to the lockdown, Dr. Rhodes must figure out a way to get into the operating room to help perform open-heart surgery. Dr. Manning and Dr. Halstead disagree on the right treatment for a patient.

Dr. Manning goes to extremely measures to help a fearful pregnant woman whose baby is severely underdeveloped. April is angered by Dr. Choi when he uses their personal relationship as leverage to convince a patient of a risky procedure. As Dr. Rhodes attempts to balance his personal and professional life, it appears the stress of his current situation may have caused him to make a huge mistake.

Halstead and Asher work to save a surrogate's baby. Charles cares for a patient on a hunger strike. Choi and Archer help a patient with ties to Choi's late father. Scott and Maggie are stumped by a drunk patient who claims to be sober.

After witnessing a drive-by shooting and hitting her head, Dr. Manning struggles with the aftermath of a head injury. Complicating matters, she and Dr. Halstead deal with a teenage patient and her overbearing older husband, who might not be looking out for his young wife's best interests. Dr. Rhodes finds himself in a unique situation when he learns alarming information about the woman he went on a date with. Maggie is surprised to discover some unexpected things about the man she has been seeing. Dr. Charles is frustrated when Dr. Reese disobeys his orders and puts herself at risk.

After discovering that a patient's family might have been abusive, Dr. Choi and April contemplate calling child services. Dr. Manning and Dr. Halstead struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes is persuaded into preforming a risky surgery on Dr. Bekker's mentor. Meanwhile, Dr. Reese joins Dr. Charles on a visit to the Cook County jail.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

After taking the lead on a surgery, Dr. Bekker feels the heat after something goes wrong. Dr. Manning and Dr. Charles are faced with a tough decision concerning the gender of a 9-year-old girl. April and Dr. Reese rush to find the son of a dying patient. Goodwin's godson is admitted to the hospital.

After a shooting occurs during a block party, the staff is overrun with victims; Dr. Choi devises a new mass casualty plan; Dr. Manning struggles to stay focused when she realizes her son and nanny might have been at the scene.

Ethan attempts to diagnose a man with no symptoms while Sarah's paranoia goes to the extreme when she uses pepper spray on an aggressive patient. Will treats a young couple willing to sacrifice anything in order to have a baby. Meanwhile, Natalie must inform a woman that she was sterilized as a young girl without knowledge, and Goodwin and Maggie devise a way to persuade paramedics to bring in more patients.

After a neighbor is stabbed, Dr. Choi enlists the help of April to figure out who is the real cause of the incident. Dr. Bekker and Dr. Rhodes expertise is put to the test when Noah misdiagnoses a patient. Dr. Charles is put in an uncomfortable position when Dr. Reese's estranged father comes to him as a patient without her knowledge. Meanwhile, Dr. Manning rushes to save a baby with whooping cough.

Upon hearing news of a pregnant teen, Dr. Manning and Dr. Choi venture to a homeless encampment to help deliver a baby under dire circumstances. Dr. Rhodes and Dr. Bekker argue about the best way to treat a young boy with a chronic disease. Dr. Halstead and April are put in an uncomfortable situation when they find out their patient is a pedophile. Goodwin and Maggie have to deal with a lawsuit against the hospital. Dr. Charles learns of important news pertaining to Dr. Reese's father.

Dr. Halstead and Dr. Manning are at odds over the care of a vegetative man; Dr. Rhodes goes behind Dr. Bekker's back to get his patient at the top of the transplant list; a woman in the waiting room falls asleep and won't wake up.

Dr. Charles and Dr. Reese search for answers when a mother brings in her daughter claiming she is possessed. Dr. Rhodes and Dr. Bekker are tasked with finding a way to save a pair of conjoined twins. Dr. Halstead struggles to get Dr. Manning's attention. Maggie measures her options in the wake of her recent actions.

Dr. Rhodes fights to save a mother who's desperate to help her daughter beat cancer. Dr. Charles asks Sarah to conduct his daughter Robin's psych evaluation. When Will and Dr. Manning spend more time together at work, Nina goes to extreme measures to get Will's attention. Meanwhile, Dr. Choi puts pressure on Noah when a residency spot becomes available.

When Goodwin receives financial complaints from the hospital board, she is forced to implement new guidelines that cause headaches for the doctors. Dr. Rhodes and Ava continue to compete in the operating room, while Dr. Charles and Dr. Reese are surprised when they treat a man who has a peculiar theory about his sickness. Dr. Manning and Dr. Cho can't figure out what is wrong with a young girl, leading them to look to a questionable source for answers.

When a young woman with HIV symptoms and no insurance refuses to take the test, Goodwin and Dr. Choi attempt to treat her without taking a toll on the hospital's resources. Natalie and Will try to diagnose a young girl with increasing paralysis. Noah deals with his first death as a resident and takes it upon himself to inform the family. Sarah continues to avoid work as her fear over the hospital's security increases.

Dr. Choi struggles to help a woman cope with anorexia. After a two-week suspension, Dr. Reese is immediately put to the test upon her return by Dr. Charles. Dr. Rhodes takes a stand when one of his patients is forcibly transferred. Meanwhile, Dr. Halstead is on a mission to get Dr. Manning's son to like him.

Bekker takes drastic action to keep Rhodes from leaving Med for good. Meanwhile, Halstead questions Manning's feelings about their upcoming wedding, Ethan receives shocking news about his sister, and Dr. Charles mourns a loss.

Sharon Goodwin's childhood sweetheart arrives at the hospital, but finds himself in dire straits. To help get his financial footing, Dr. Halstead gets lured into a concierge doctor app idea. Meanwhile, a young woman with a heart infection is treated by Dr. Rhodes against Dr. Charles' advice and Reese's former patient, a sex trafficking victim, reaches out to her for help.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to best handle the boy's parents. Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.

The doctors and nurses of Chicago Med find themselves on high alert when an overflow of patients are rushed into the doors following a terrifying apartment complex blaze. Dr. Rhodes fights to save the life of one of Chicago Fire's own, while Dr. Halstead and his brother Jay struggle with their own personal battle. The crossover starts on Chicago Fire S07E02 Going to War (I). It continues on Chicago P.D. S06E02 Endings (III).

When a sick boy is brought in, Ethan is faced with a tough decision that quickly escalates into a complicated and dangerous situation. Connor and Maggie are put to the test, while Natalie and Ethan aren't sure what to make of Elsa, the new third year medical student.

Dr. Charles learns a troubling fact about the man who shot him. Dr. Rhodes and Dr. Bekker come to an agreement during a complicated surgery. Will and Natalie are trapped by legal ethics when an unfaithful husband refuses to tell his wife about his inconclusive Zika test. Meanwhile, April and Noah discover working together isn't always easy while Goodwin continues to argue with the board over hospital costs after an avoidable patient death.

Dr. Halstead gets an unplanned visit from the CPD while Ethan is skeptical of a woman who is experiencing chronic pain. Natalie tends to a cancer patient whose brother has strong feelings on why he is refusing to lend his assistance

Goodwin tasks Dr. Charles with evaluating a patient as a possible heart recipient, while Jeff makes a confession to Dr. Manning. Dr. Choi deals with two MMA fighters who are brought into Chicago Med in bad shape. Elsewhere, Dr. Stohl returns to the hospital from his sabbatical leave and immediately offers up different medical opinion regarding the treatment of a patient under the care of Dr. Halstead. April discovers her TB medication may lead to further complications.