The Cow and Chicken`s teacher sings a ballad about Red Guy and Cow and Chicken.

Mom and Dad decide to let Cow have a pet. She choose an anaconda, after it eats Chicken, and she hears his voice from inside the snake, and assumes the snake can sound just like Chicken. Cow names the anaconda, Fluffy, and Fluffy soon grows attached to Chicken, as its full-coarse dinner.

Cow's tongue rips out of her mouth and runs away. He then causes havock all over town, by hi-jacking someone of their motor-scooter, rolling around in someone's gravy, and licking the candy store dry. Soon, Tongue finds himself on the lam, and runs back to Cow. Everything is back to normal, until Chicken's wattle decides to run away to.

Cow and Chicken get an unexpected visit from Cow's twin cousin, Sow (a pig with 8 teets). After Sow's first day at school, she causes chaos, and puts the blame on Cow. It's up to Cow to pull the plug on Sow's evil ways.

I.R. finds an abandoned baby and adopts him as his son.

Weasel and I.R. create their forms of life.

Cow brings home an ""invisible"" dog, whom she dubs, Kevin. Pretty soon, she and Kevin are inseperable, but causes trouble with school and friends. After she enters Kevin in a dog show, and wins, Kevin ""runs away"". Afterwards, Cow finds Kevin, befriended an ""invisible"" homeless man.

The Red Guy is now Captain Butz Pirate, and wants to give Cow and Chicken pirate lessons. He takes them aboard his pirate ship in the middle of the duck pond, and teaches them how to say ""argh"", carve peglegs, hold worms for ransom, and sink Flem and Earl's boat. But after that incident, Cow, Chicken, and their flag/man Jolly Roger declare mutiny.

Chicken is tired of always having to do chores, so he chews Mom and Dad out, and runs away to be a bachelor with Cousin Boneless Chicken. One at Boneless's Chicken attracts the attention on Boneless's blind-date, Linda. Linda falls head over heals for Chicken, which makes Boneless disgusted.

I.R. hurts himself while walking up to Weasel's house! Weasel discovers that I.R. has broken his phantom foot! When I.R. goes to see Dr Clearbottom on phantom limbs, this doc's services are at a very high price! Weasel later reveals that it was Clearbottom who dug the hole which injured I.R.'s phantom foot so he can take all his money!

The Red Guy is depressed because no one will play with him. After seeing Cow has Crabs the Warthog, he wants to play with her because he has Crabs's doll house. When he askes to play with Cow, she tells him not if he was the last man on earth. With that he locks the entire world in a trailer, and is the last man standing: but Cow still won't play with him.

Weasel creates a time machine that I.R. uses to go back in time, but Weasel discovers that I.R. is destined to solve all kind of problems at certain periods.

Cow is depressed because she has no friends: until she finds a fly in her room and befriends it. Pretty soon she and the fly are inseperable: until Chicken, Mom and Dad call in the fly exterminator.

Weasel is the captain of his own comercial plane, and must take a bunch of people up a river with I.R. as his co-pilot.

Chicken, Flem, and Earl play a game of kickball. Cow's udders kick the ball into the bushes, where Chicken, Flem and Earl discover a laughing puddle. After Flem and Chicken run back out, they forget the ball, and go back to discover that Earl is in the puddle. Chicken sends Flem after him, and he is stuck too. Chicken then gets Mom and Dad, who jump into the puddle, and Chicken drops Cow in there to save everyone. Chicken is then the only one left, until he discovers the puddle is a doorway to Boneless Chicken's nightclub.

The Red Guy hosts a new late night talk show called ""Dead Ghost, Coast to Coast"", and reminds the viewers that tonight's Halloween. Chicken calls in, and is instructed to dress as a human being. So, Cow and Chicken go trick or treating as Mom and Dad, only to find that the neighbors assume that a grown man and woman are trick or treating. With that, Super Cow and Chicken teach The Red Guy a lesson.

Weasel must relocate the people who suffer from the cronic crybaby syndrome, not knowing that they are the main source of water on the planet.

Cow and Chicken's class go on a field trip to the Cometorium, where Chicken is bored stiff. After getting hit by one of Dad's golf balls (he was golfing right next door), Chicken hangs it in front of the telescope; soon, the whole town is in panic of the arrival of ""Dad's Ball Comet"".

The school's newspaper editor has been fired. Teacher then brings in The Red Guy, as reporter Geraldo Rearviewa to advise. He decides to produce a new school-news show, and makes Chicken the anchorman, and Cow the editor. But soon, Red Guy's false stories makes Chicken loses friends.

Mom and Dad go out of town, leaving Cow as the babysitter, because she's the biggest, and not the oldest. Pretty soon, Chicken is at the mercy of his sister's babysitting technique: eating marshmallow soup for supper, doing homework with Crabs the Warthog doll, Piles the Beaver doll, and Manure the Bear doll, taking a bath and being scrubbed with dishsoap, and wearing diapers.

Weasel comes to investigate the world's largest hole, same hole I.R. tries to fill with cement.

After Earl gets the new Sergeant Weenie Arms action figure, he, Flem and Chicken go to Dead Skull Cave to meet the soldier himself, and become full-fledge weenie marines. After they do so, they learn that weenie marines are sissies.

Cow, Chicken, Flem, and Earl try out for the school's sumo wrestling team. For being big and fat, Cow is the new team member. Soon, everyone fears her, and she feels degected, but it benefits Chicken, because now no one will beat him up.

Cow stays outside too late, and pretty soon finds herself lost in the woods, and tries to survive. She pretty soon comes to the conclusion that it's eat, or be eaten, so she puts on war paint, and finds a squirrel in a bush, she quickly eats. It turns out she was in the backyard all the time, and her imagination got the better of her.

Weasel and I.R. are sent to a correctional institute were everyone is forced to wear stupid corrective devices.