Picking up where the season 4 finale left off. The team is investigating the death of a woman named Lauren Santana whom is linked to the bank robbery. She is a friend of Flack's sister Samantha. Also Mac has escaped the robber but the bodies are still piling up. So the team must quickly find the bank robber before he is able to get away.

A series of deaths from radiation poisoning may be related to a deadly tome in the New York library.

When a supposed air marshal is murdered on a flight to the District of Columbia, Mac searches the plane for the killer and the murder weapon.

The team investigates the puzzling death of a woman named Ann Steele. To solve the case, the team must look for a life size silicone doll. When the team runs into the factory that makes them, it prompts some amusement for some of the team. Meanwhile, Hawkes meets up with an old college friend who later asks him to compromise some evidence in the case.

The CSI team investigates the shooting death of an archaeologist whose secret life may have caught up to him.

Three drug dealers set to stand trial are found dead in separate places. They were all trying to get rid of witnesses in their crime, but it looks like someone got them first.

The team investigates the brutal murder of a house relocator who was found dead inside a Victorian house that he was about to move from Staten Island to The Upper East Side.

In the one hundredth episode of CSI: NY Mac faces his most deadly foe yet. There is a serial killer loose in New York City killing people with the name Mac Taylor making Mac a target.

A woman is found in the trunk of a crushed car at an auto wrecking yard, the autopsy reveals that she was pregnant, the team needs to find out who she is so they can find the baby.

The team is forced to investigate two crimes at once when a mysterious energy field seems to be the cause of a billionaire's disappearance and the death of his limo driver.

Mac runs into Ella McBride who could cost him time in figuring out if Isabelle Vaughn died by eating the miracle fruit. Stella gets in trouble with Mac while investigating another murder linked to the Greek diplomat that attacked her.

Young brides-to-be fight over a killer dress at the biggest wedding gown sale of the year and one of the shoppers winds up dead. The unusual clues of this case force Dr. Hawkes to confront a painful chapter from his past.

The CSIs must piece together a human jigsaw puzzle when a beloved wrestling coach's severed body parts are found buried throughout the city. Meanwhile, Detective Flack is in the hot seat when a teenage suspect dies in his custody.

A Russian tourist is found stabbed to death and the CSIs come face to face with the frightening realities of human trafficking. Solving this case becomes personal when it directly affects a prominent member of the NYPD

When the Deputy Mayor's dead body falls from the ceiling, along with hundreds of balloons, at a charity fundraiser, Stella and her date find themselves in the middle of the crime scene and Mac goes head to head with Robert Dunbrook.

When a buzzard flying over Manhattan drops a human eyeball from its claw, the race is on to find the body it belongs to before the avian saboteur flies away with the rest of the evidence.

A lethal pipe-bomb blows a Manhattan townhouse and valuable evidence to pieces, forcing the CSIs to get creative in reconstructing the damaged clues that ultimately lead to the bomber.

When the wife of a former medical examiner is found murdered, a white powder found at the scene provides the CSIs with a major lead in tracking the killer when it is discovered that the powder is heroin made from human bodies.

When a Native American chief is shot on the subway, the CSIs struggle to translate which one of the several foreign suspects may have caused his death.

While investigating the shooting of a voice coach in an empty theater, Stella realizes that the crime scene is oddly familiar and staged.

When a man falls 20 stories to his death, and his body goes missing after it hits the ground, with no body to process, the CSI's must treat this strange development as a missing persons case.

The most exclusive jewelry auction of the year ends abruptly when an appraiser is killed during the event. The investigation takes an emotional turn when the CSIs must confront one of the greatest tragedies in human history - the Holocaust.

Mac informs an ex-con that he served time for a crime he didn't commit, and Lindsay tells Danny "it's time" for the first CSI baby to be born.

When Stella discovers that New Yorkers are being murdered over ancient Greek artifacts, she hands over her badge to follow a clue that leads to Greece and, together with Mac, she uncovers one of the greatest mysteries in history.

When transferring Robert Dunbrook's son from prison to court, the NYPD is ambushed by a group of professional kidnappers who kill a member of the team and one of the CSI's lives hangs in the balance.