While Sully is off thinking and doesn't return for several days, Mike gets worried. Although Mike continues to believe in their love. When Sully finally returns, Mike realizes she just wants Sully as her husband. Mike and Sully marry on May 20, 1870. Brian, feeling left out, has a surprise for the newlyweds.

Matthew's fiance Ingrid hovers near death after being bitten by Brian's rabid pet wolf; Brian is overwhelmed with guilt. Ingrid: Jennifer Youngs.

Sully and the kids must help Mike deal with the emotional aftermath of the Washita massacre; Robert E and Grace must return to Cloud Dancing the Indian baby Mike and Sully brought back from Washita

The rescuers get ugly after Leonard offers a bounty for the mountain man, so Sully sets off alone.

A sick and ragged prospector wanders into town and Jake Slicker recognizes the man as his father, who abandoned him years before.

Cloud Dancing is badly beaten by soldiers for returning late to the reservation. Michaela treats him. When Sully learns of the attack, he is outraged. Tired of being treated cruelly, the tribes plan a rebellion. They enlist Sully's help.

Sully lies to everyone about what he is doing, but the truth comes out. Cloud Dancing flees to the Tongue River Valley. Sgt McKay (David Beecroft)sees Sully at the scene. After Sgt O'Connor (Patrick Kilpatrick) finds out what happens, he goes after Sully. They get into a fight and they both go over a cliff

Anthony's (Brandon Hammond) health deteriorates rapidly. Grace does not want to face the inevitable. Michaela struggles to tell Sully about the baby. Anthony loses his battle.

When Mike and Sully stop to check on old Mrs. Johnson, they discover her dead and a young boy, Zack, hidden in the closet. Mike takes the child in and confronts the townsfolk, who reluctantly admit to knowing the boy's mother was one of Hank's whores. When she died they sent Zack to Mrs. Johnson because he was ""simple."" Mike is frustrated in her attempts to find a medical diagnosis and cure for Zack's condition. Mike's further detective work reveals that Hank is Zack's father, and she helps Hank own up to his responsibility. Meanwhile, Brian seems to be the only one to get the boy to exhibit his artistic abilities, and he is mistakenly given credit for a drawing that Zack has done. Later, when Zack's artistic talent is discovered, Hank agrees to send him to an art school in Denver. The show has a cute opening scene of Mike and Sully with him criticizing her driving.

Mike receives an emergency telegram from her sister Rebecca -- her mother is gravely ill. Mike rushes to Boston to her mother's side, the Cooper kids in tow, where Dr. Mike and her ""roughhewn"" children are met with raised eyebrows by Dr. Quinn's own family. While consulting with Elizabeth Quinn's attending physician, Dr. Mike meets a handsome and progressive Doctor, Dr. William Burke. Dr. Mike's prognosis of her mother (hepatitis) differs with Mrs. Quinn's doctor, Dr. Hanson, who diagnoses cancer. Dr. Burke, however, believes Dr. Mike may be onto something. They have a lot in common and develop a strong mutual admiration for each other. They work together to cure Mrs. Quinn and some of Dr. Burke's other patients. Meanwhile, Matthew chafes at being stuck in Boston away from Ingrid, while Colleen appreciates the learned and cultured atmosphere and Brian adores the candy stores. Just when everyone has settled comfortably into the Boston routine, Sully shows up, unannounced and in buckskin

Sully arrives in Boston and discovers that he's facing worthy competition for Mike's affection in the form of Dr. William Burke. Sully at first settles uncomfortably into Mike's Boston surroundings, but later, with prodding from the kids, submits to a grand makeover. Later, Sully romances Mike with dining and dancing, even attending an opera together. At an all-male medical society, Dr. Burke steps aside so that Mike can present a paper on Indian medicine, while Sully looks on. Afterward, Sully overhears Dr. Burke proposing marriage to Mike and heads back to Colorado, but not before confessing his love to Mike. In the end, Mike declines Dr. Burke's marriage proposal and Mike and the kids return to Colorado, where Dr. Mike returns Sully's declaration of love with a vow in kind.

Robert E buys a house in town. When the auctioneer, Jedediah Bancroft, sees that he's sold the house to a black man, he tries to renege, but Mike intercedes. Later, Mike is surprised to learn that Jake, Loren, Hank and Dorothy are displeased to have Robert E and Grace living in their midst. That night, at the homestead, Matthew tells Mike he's been invited to join a new men's club -- the Ku Klux Klan, which he knows nothing about but is heading out the door to investigate. At the meeting, Jedediah, the leader of the group, promises only ""a big surprise"" for the following night, then adjourns the meeting. The next night, townsfolk don white gowns, recite the KKK oath, and ride out to harass and beat Robert E. After treating Robert E, Mike storms into the barbershop, where she confronts Jedediah, Jake, Loren and Hank about the events of the night before. Jedediah tries to make offers to get Robert E and Grace out of town, even threatening Mike with the mortgage on her clinic if Robert E

The town is duped by two con men selling shares in a refrigeration box and Mike must turn the tables on the con men, helping the town learn a lesson in trust. Meanwhile, Cloud Dancing barters with Loren to sell corn grown on the reservation at the general store. Randolph Cummings: Brandon Douglas. Curtis Roper: Anthony Lee. Anthony: Brenden Jefferson.

Feelings run high after a drifter is sentenced to hang for rape and murder

Michaela has returned to work after being home with Katie. Between work, the baby and being so tired,Michaela is spread thin. Sully feels neglected. Sully helps Michaela through this difficult time. Colleen is accepted to college in Denver.

A severe storm bears down on Colorado Springs, disrupting the arrival of Preston Lodge II and Dr. Mike's attempts to prepare a Thanksgiving dinner.

When three people die after coming in contact with something in the clinic, and one is deathly sick, Dr. Mike, Sully, Colleen, and Andrew but their heads together to find out what it was. They figure out that it was something in the clinic and now it is everywhere. In her case, on the instruments, the sheet. The only solution is to burn everything. When that is done, some are genorous enough to give Dr. Mike some of there things, but they are scared to come in. When Sully must get stitches, and lives after being treated by Dr. Mike, she begins the road to being reaccepted by Colorado Springs.

Sully sets out to rescue Mike. Meanwhile, Custer takes the Indian reservation hostage, threatening to hang everyone unless Mike is returned. Brian works off the cost of the little horse; but Hank reneges on the deal, inciting Loren's wrath. Mike and Sully return to town just in time to keep the Indians from getting hanged. Hank, not anxious to pay double for all his goods at the General Store, delivers Taffy to Brian on his birthday, declaring that, ""Sometimes it's just good business for a man to keep his word.""

Robert E and Grace want to adopt a young boy who is suffering from a disease Mike can't diagnose (sickle cell anemia). Meanwhile the town believes Matthew should start dating again and sets him up on a series of blind dates.

The Reverend mortgages the church to Hank to get money to make church repairs in order to impress his mentor Rev. Thomas. Rev. Thomas: Fred Rogers. Mr. James: Max Gail.

Tales of her accomplishments embarrass Woman of the Year nominee Mike; Hank's grandmother visits.

A popular new arrival carries a dread disease; Preston plans an exclusive clinic.

Cloud Dancing hopes his trial for shooting a soldier will unite the tribes.

Wounded Sully must deliver Mike's baby. Dr. Cook is forced to perform a major operation. Katie Sully: Alexandria, McKenzie and Megan Calabrese.

Dr. Mike faces the prospect of leaving her practice and friends for Wyoming when Sully is offered a job surveying Yellowstone National Park.