A sick and ragged prospector wanders into town and Jake Slicker recognizes the man as his father, who abandoned him years before.

Kid Cole and Sister Ruth (Johnny Cash and June Carter Cash) visit Dr. Mike at a difficult time in their marriage.

Cloud Dancing is badly beaten by soldiers for returning late to the reservation. Michaela treats him. When Sully learns of the attack, he is outraged. Tired of being treated cruelly, the tribes plan a rebellion. They enlist Sully's help.

Sully lies to everyone about what he is doing, but the truth comes out. Cloud Dancing flees to the Tongue River Valley. Sgt McKay (David Beecroft)sees Sully at the scene. After Sgt O'Connor (Patrick Kilpatrick) finds out what happens, he goes after Sully. They get into a fight and they both go over a cliff

Michaela has returned to work after being home with Katie. Between work, the baby and being so tired,Michaela is spread thin. Sully feels neglected. Sully helps Michaela through this difficult time. Colleen is accepted to college in Denver.

A severe storm bears down on Colorado Springs, disrupting the arrival of Preston Lodge II and Dr. Mike's attempts to prepare a Thanksgiving dinner.

When three people die after coming in contact with something in the clinic, and one is deathly sick, Dr. Mike, Sully, Colleen, and Andrew but their heads together to find out what it was. They figure out that it was something in the clinic and now it is everywhere. In her case, on the instruments, the sheet. The only solution is to burn everything. When that is done, some are genorous enough to give Dr. Mike some of there things, but they are scared to come in. When Sully must get stitches, and lives after being treated by Dr. Mike, she begins the road to being reaccepted by Colorado Springs.

Sully arranges an escape for Cloud Dancing, leading him and the Indian to become wanted men.

Dr. Mike faces the prospect of leaving her practice and friends for Wyoming when Sully is offered a job surveying Yellowstone National Park.

Dr. Mike is arrested and put in jail for treating a fugitive Indian; Jake and Preston run against each other for mayor of Colorado Springs.

Dr. Mike, Sully and Matthew team up with a legendary marshal in order to nab the thieves who wounded Matthew during a bank robbery.

Grace and Robert E. encounter fierce opposition when they attempt to enroll their son in the town's all-white school.

As Christmas approaches, Brian questions his faith when he learns that Dr. Mike cannot save the sight of the Reverend.

After Marjorie joins the Women's movement she blows into town stirring everyone up and has a fling with Loren.

Sully goes to Denver to negotiate the release of Cloud Dancing from the army. One of the conditions is that Sully is no longer Indian Agent and may not ever step foot on the reservation again. On the way home the train crashes, injuring most on board. Andrew learns a lesson in humility by watching Michaela in action.

A malpractice suit prevents Dr. Mike from practicing medicine, leaving the reluctant Dr. Cook in charge.

The appearance of renowned singer Gilda St. Clair (Barbara Mandrell) tempts Colleen to leave college and travel the world instead.

Dr. Mike's Uncle Theodore, a concert pianist, sees in Brian not only a talented musician, but his own dead son.

Everyone is doting on Katie and Brian feels slighted. Brian receives a letter and picture from his real father, which leaves him feeling like he doesn't belong anywhere. Brian starts behaving badly. He gets Anthony to skip school with him and they hop a train. Sully punishes Brian. When Brian questions Sully's actions, Sully says that he is doing it because he is his Pa.

A Latin American woman rebuffs Dr. Mike's attempts at friendship; the Rev. Johnson searches for a teacher to take his place. Teresa: Michelle Bonilla.

Sully, depite being wounded by two bank robbers, works to free his wife, Brian and Katie when they are taken hostage by the desperate men.

Brian takes a liking to visiting writer Walt Whitman, even when the townspeople shun Whitman over rumors of his alternative lifestyle.

In a case of mistaken motivation, a judge sends Sully to prison after he is spotted with criminals bent on stopping the construction of a dam.

When Colleen, who is working on a college paper, asks Dr. Mike to recall her most memorable case, Dr. Mike looks back on the five turbulent years she's lived and loved in Colorado Springs. As they sit with Andrew, who is mysteriously ill at the clinic, Dr. Mike reminisces about her tumultuous career -- its successes and its failures -- and realizes how many divergent cases she has seen and treated. When Andrew's condition takes a turn for the worse, Dr. Mike warns Colleen about the fine line between emotional involvement and professional detachment, an issue with which she has long struggled in the frontier town that's now her home.

While Sully is away for a few days to procure some money, Preston arrives threatening to repossess the homestead for nonpayment of the load. Daniel rejects Dr. Mike's objections and pays off the entire loan. Upon hearing how Daniel interfered in his business, the proud Sully becomes furious.