While holiday shopping, Barnes and Jess are caught in the middle of a mall shooting, with the exits rigged so no one can escape. Also, Gaines, Hana and Ortiz try to help from the outside, knowing their team's family members are inside and at risk.

After Hana is kidnapped while trying to help a young girl in peril at a rest stop that's on the way to her sister's house in Connecticut, Remy and the team pull out all the stops to find her.

The team pursues an abusive man on the war path to find his ex-girlfriend, who is trying to escape him for good. Also, Jess and Sarah make plans to take their dream vacation together.

The team helps Remy try to catch his brother’s real killer 25 years after Mikey was murdered.

When a federal judge and his wife are shot dead in New York, the Fugitive Task Force goes on the hunt and finds a connection to a man who is hours away from being executed in Missouri. Meanwhile, Remy and Hana both grapple with being single and living alone.

The team welcomes a new member as they begin their hunt for a repeat offender and the child he kidnapped after murdering the boy’s single mother. Also, Jess tries to move past the awkward exchange he had with Sarah during their last encounter.

The witness Remy and Kristen are visiting in prison is put in danger when a riot breaks out, leaving the staff and visitors held hostage by two murderous gangs.

The Fugitive Task Force clashes with local law enforcement in Virginia while investigating a suspected serial killer in the area. Meanwhile, Remy pushes Abby to take the next step.

Remy calls in the Fugitive Task Force after ex-girlfriend judge April Brooks is assaulted by a serial rapist. Meanwhile, Remy decides to take the next step in his relationship with Abby after her case in New York winds down.

After taking down a terrorist, the FBI and their Fugitive Task Force partners turn their attention to the terrorist’s wife who escaped with one million dollars and is determined to follow through with her husband’s deadly plan. Also, LaCroix’s daughter, Tali, is taken away by ICE, but as Jess tracks her down, he realizes her detainment may be more than just random coincidence. The crossover starts on FBI S02E18 American Dreams (I).

Jess and the Most Wanted team head to Tennessee to track down an undercover DEA agent who appears to have turned dirty amid a major drug ring operation. Also, Sarah wonders if it was a mistake to move in with Jess and Tali so soon.

When a domineering man and his girlfriend embark on a terrifying multi-state killing spree, the team races to find a pattern behind the deranged couple's seemingly random acts of extreme violence. Also, Jess worries he's being left out of Tali's life when he finds out his daughter has already won an award at school.

After a robbery gone wrong ends with a murder and kidnapping, the team races to rescue a mother and daughter whose abductors are not what they seem. Also, Crosby enters a new living arrangement.

A local FBI case involving two murdered women and a sea of powerful men turns into a manhunt for the dangerous leader of a far-reaching criminal enterprise. The crossover starts on FBI S04E01 All That Glitters (I). It continues on FBI: International S01E01 Pilot (III).

The team investigates the murder of a professional basketball player’s wife, who was a famous lifestyle guru. Also, Kristin and her ex-husband grow closer, and Special Agent in Charge Isobel Castille checks in with the team on the high-profile case.

The team searches for a murderer recreating the chilling killings of a notorious ‘80s mobster.

When a celebrity child psychiatrist is kidnapped by the relative of a former client, the team races to track down the perpetrator and learns what really happened to the psychiatrist's client; Kristin confronts her deep-rooted trauma.

The clock ticks as the FBI and FBI: Most Wanted teams join forces to hunt down the fugitive terrorists as they get closer to carrying out a plot to destroy a major New York City landmark and cause devastating civilian casualties. The crossover starts on FBI: International S02E16 Imminent Threat (I) and FBI S05E17 Imminent Threat (II).

When two NYPD officers are gunned down by a mystery assailant while responding to a robbery, the Fugitive Task Force must act quickly to catch the culprit before more officers are targeted. Meanwhile, Barnes struggles when Charlotte wants to proceed with a divorce and threatens to relocate with the kids.

When a military veteran suffering from PTSS snaps after the death of his brother in arms, the decorated sniper’s expert abilities push the team to their limits. Also, Crosby’s personal struggles bubble to the surface when the case begins to hit too close to home.

The team chases an unlikely serial killer whose end game takes a shocking turn. Also, Hana returns from medical leave, and Jess and Sarah's relationship continues to evolve.

The team goes after the killer of a man in witness protection but finds there’s more to the case than meets the eye. Also, Remy is challenged by what he discovers when he reconnects with his mother, Betsy, in person.

When a wealthy East Hamptons couple are killed by a female con artist posing as a personal trainer, the team works to find out her true identity and track her down. Also, Ortiz is put in a tough place when Hana's brother asks a favor.

When a news anchor is shot dead in the station's parking lot, the task force must dive into a story she was working on to track down her killer; Remy debates revisiting the case around his brother's murder.

When a mob-connected police informant is found murdered before a major crime boss is being indicted on federal charges, the Fugitive Task Force goes on a hunt for the killers. Meanwhile, Hana grows closer to Ethan.