Eva discovers that Alex has been lying to her: he isn't the head chef at the restaurant where she works, but merely an assistant. By chance, she encounters Selvaggia, a spoiled and overbearing teenager who, blinded by jealousy, stalks her boyfriend Daniele. Eva encourages Alex to never settle and pushes him to accept a catering job for a birthday party, which turns out to be Selvaggia's mega-party! Eva receives a visit from her father Sergio, who still doesn't know Alex. The two hit it off, and Sergio suggests that Alex work at a restaurant in Milan where he will be a partner. Eva urges him to accept, but Alex wants to be with her as much as possible, so overworking isn't a good idea. Jolanda decides to celebrate her fifteenth birthday in style and asks Alice for help organizing the party in Walter's warehouse.

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Giulio Cesaroni and Lucia Cudicini, he a widower, she separated, meet again after twenty years in Rome. They realize they still love each other and decide to get married, so Lucia's daughters, Eva and Alice, arrive from Milan and move in with the Cesaronis. Getting to know Marco, Rudi and Mimmo, Giulio's sons, is not easy and things are also complicated by uncle Cesare, Giulio's brother, and his jealousy. Sergio wants Lucia to get back together with him, but after her ex refuses, the ruthless manager goes to Giulio's liquor store and threatens to take away his future wife, daughters and job. Giulio acts on impulse and doesn't hesitate to punch him, so Sergio, with the complicity of a doctor friend, makes the Cesaronis believe he is dying.

The Cesaroni's great soccer dream is about to come true: Romulana could make the jump in category. Giulio uses legal and illegal means to achieve victory, while Cesare does everything he can to ensure Romulana loses.

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Giulio helps Rudi study for his class test, but the boy gets a bad grade for the umpteenth time. Meanwhile, the school newspaper edited by Alice reports a secret relationship between a student and a teacher, and Rachele, thinking that Marco is to blame, tries to get revenge. Rudi and Alice manage to make amends. At school Rudi and Alice compete for the role of gang leader, while Lucia, depressed by her absence from teaching, devotes herself with obsessive attention to household chores, worrying Giulio. Marco, abandoned by Rachele, confesses to Eva that months before he had been in love with her.

Rudi, miraculously promoted, refuses to work in the wine shop, resorting to the blue telephone. The intervention of social services helps Giulio and Lucia to teach the little rascal a lesson. Meanwhile, Eva's departure does not go down well with Lucia.

Giulio must serve a two-match suspension as the Romulan coach following a heated argument with a referee and is forced to ask Ezio to replace him on the field. Meanwhile, little Mimmo is struggling with a difficult assignment for him: an essay about his mother. The child, who remembers nothing about Marta, his dead mother, asks his father and brothers for news. Marco learns that Eva is going to London for a weekend and would like to accompany her, so he tries to scrape together the necessary money and his uncle Cesare finds him a job as a liscio player with a small orchestra of over-sixty year olds in a club. Meanwhile, Ezio, because of a prank by Giulio and his brother, argues with Stefania and leaves home.

Giulio and Cesare are convinced that Ezio has contracted the Ebola virus, infected by the parish priest Don Luciano who has just returned from Africa. The three friends believe they are infected and lock themselves in a wine shop, drunk, awaiting death.

Rudi takes part in a psychological test and the result, to everyone's surprise, is that the boy is a genius. Giulio, enthusiastic, does everything to satisfy his son's needs and stimulate his intelligence. Alice, suspicious, discovers that the Leonardo da Vinci of Garbatella copied the answers. Lucia convinces Rudi to confess and the father's punishment is not long in coming. Marco seems increasingly strange and it is now clear to everyone that he is in love. However, no one suspects that the lucky girl is Eva. Meanwhile, Sergio shows up at the Cesaroni house and, on the verge of being named Cavaliere del Lavoro by the President of the Republic, he would like to take advantage of the opportunity to embarrass Giulio and win Lucia back.

Lucia plans a group vacation at a campsite in Sardinia, but friends and relatives have other plans and one by one they back out, so Giulio and Lucia are forced to leave alone. Eva, convinced by Giulio to forget Marco, for the good of the family, follows Veronica to Croatia, while Marco and Walter leave for Greece.

Giulio and Lucia Cesaroni organize the ritual barbecue that marks the end of summer. Among those present are Giulio's inevitable brother, the mechanic Ezio Masetti and his wife Stefania, a friend of Lucia and the principal of the school where they both teach. Obviously Lucia's mother, Gabriella, is also there, while the youngest of the family, Mimmo, observes that this year the doors of middle school are opening for him. For Alice and Rudi, always dog and cat, instead the much more terrifying doors of high school are opening wide! The firstborns Marco and Eva are far away: he studies music in Milan while she is in New York to specialize in journalism and live with her chef boyfriend, Alex. Their friend Walter, son of Stefania and Enzo, is left hanging around Garbatella, drooling over Carlotta, his beautiful girlfriend from the upper neighborhoods. While walking with Rudi, his passion for mechanics leads him to notice a splendid vintage motorcycle that he inadvertently knocks over.

On the advice of the doctor, who fears a new trauma, the Cesaronis indulge the amnesiac Francesco who believes himself to be Giulio. The man usurps the innkeeper's place at home, in the wine shop and also next to Lucia.

Marco, feeling neglected by Criscuolo, decides to leave. However, the record producer warns him that if the musician terminates his contract, he will have to pay a penalty of thirty thousand euros, representing the expenses he has incurred up to that point for his promotion. And, to spite him, he entrusts him with the task of creating the jingle for a toilet paper commercial. Lucia points out to Giulio that it's partly his fault: Marco, before signing the contract, had asked his father for his opinion. Eva gets an opportunity: she's called to the editorial office of the trendiest magazine of the moment, the famous Up To You. She's welcomed by Cinzia, assistant to the newspaper's fearsome editor, Iva Zavattini, who never shows up in the editorial office. In such a competitive environment, the apprenticeship is brutal: Eva is tasked with organizing the archives.

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After years of absence, Augusto Cesaroni, Giulio and Cesare's brother, leaves the United States and returns to Rome. Giulio, who has always believed Augusto to be a rich and powerful former race car driver, has to change his mind. The man, full of debts, has actually shown up only to claim his share of the liquor store. Meanwhile, Rudi blackmails Alice because of his stepsister's affair with a boy.

Alice hangs out with a bully named Riccardo who, in order to be accepted by Giulio, tries to appear serious and studious. When the innkeeper, with Rudi's help, discovers the boy's true nature, he reserves his most classic punishment for him: the broom. Meanwhile, Marco, while still being troubled by his feelings for Eva, lets himself be seduced by Rachele, the new teacher.

Matilde accidentally meets a colleague of Pamela's, the prostitute Godiva, who has just been released from prison. Naturally, the young girl doesn't know what her beloved mother's profession was, believing her to have been a noble benefactor. When Matilde comes up with the idea of organizing a memorial in her honor, Cesare and the Cesaroni family are shocked: no one dares tell her the truth. A man with a seductive yet disreputable air shows up at the Cesaroni wine shop asking for news of Pamela's daughter. His name is Lojacono and he claims to be Matilde's father. Cesare puts up a fight, but Ezio, with his clumsiness, even takes the stranger home to avoid him! A debate erupts at the Cesaroni family: what if Lojacono is really Matilde's father? What right does Cesare have to prevent them from meeting?

Iva Zavattini calls Eva: she assumes she's in Friuli for the investigation she's entrusted to her and recommends she return to Rome immediately to interview the famous athlete Tiziano Marrese. The child prodigy of Italian track and field has never given an interview because he's dependent on a controlling mother, and the "stolen" meeting could prove to be a real scoop. It's Giulio's birthday, but tensions are palpable in the Cesaroni household. Lucia remains conflicted about the country house, even though Sergio, her ex-husband, has denied her the loan. She'll be met by Sonsei, who received a large inheritance following his wife's death. The former school janitor, who was never lame, now wants to settle all accounts with his past. He shows up at Stefania's house, telling her he'll help the high school renovate the gym. He also wants to repay the Cesaronis, who helped him when loan sharks were harassing him.

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After a meeting with the school psychologist, Giulio tries to imitate Lucia in his relationship with his children, who are worried about their father's change. Meanwhile, Lucia feels lost when Eva confides in her that she intends to make love for the first time with her boyfriend and has a tough fight with her daughter. There is tension in the Cesaroni household. Lucia is so busy with work and household chores that Giulio hasn't been able to have a moment of intimacy with her for several days. Meanwhile, Marco has a fight with Lucia, guilty of having taken the guitar from the closet that reminds the boy of his deceased mother. However, things smooth out and Marco starts playing again.

Giulio and Lucia Cesaroni organize the ritual barbecue that marks the end of summer. Among those in attendance are Giulio's ever-present brother, mechanic Ezio Masetti, and his wife Stefania, a friend of Lucia's and the principal of the school where they both teach. Lucia's mother, Gabriella, is also present, of course, while the youngest member of the family, Mimmo, remarks that this year the doors to middle school are opening for him. Alice and Rudi, always a cat and dog, are instead opening up the far more terrifying doors of high school! Their eldest children, Marco and Eva, are far away: he studies music in Milan, while she's in New York majoring in journalism and living with her chef boyfriend, Alex. Their friend Walter, Stefania and Enzo's son, has remained hanging around Garbatella, drooling over Carlotta, his beautiful girlfriend from the upper-middle classes.

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While Augusto, out of the hospital, starts a relationship with Gabriella, Eva returns from Milan with her friend Beatrice. Giulio, hoping that Marco will fall in love with her and forget his stepsister, convinces his son to organize a party. Marco, however, disappoints his father's expectations. Meanwhile, Lucia, due to the return of Professor Zuppante, has to leave school. Giulio, Cesare and Ezio are about to leave for the traditional fishing trip when Sergio, seriously ill, shows up again. The three, suspicious of the sudden arrival of Lucia's ex, kidnap him and take him with them to Abruzzo. Upon returning to Rome, his illness revealed, the man says goodbye to his family and leaves for treatment in the United States, accompanied by Lucia, encouraged by Giulio.