After two weeks of heated discussions and arguments, the crisis between Giulio and Lucia hasn't subsided. The two have decided to separate. Giulio acts calm, but it's just a facade. He begins to have a crisis and decides to seek therapy from Emma, the sister of Olga, the wedding planner for Cesare's wedding. Things are also getting tough for Ezio: he argues with Walter, who wanted to repair a motorcycle at the shop.

Giulio, in the midst of therapy, is still suffering. Furthermore, he believes Ezio and Cesare are ignoring him, but they are only doing so for his own good. After going to Venice with her mother, Alice returns to start school again. At class, Rudi meets a new student: Miriam, Olga's daughter. Mimmo also meets Andy, the wedding planner's other son.

Marco and Eva, who have decided to stay at the Cesaroni house to help Giulio, are unable to sleep because of Marta's crying, as she's teething. Alice, on the other hand, has met a wonderful boy and would like to make love to him, but she's not ready yet. Walter, who had lent her the house, is relieved.

Giulio's moment of truth has arrived with Lucia. A new traffic cop is terrifying everyone in Garbatella: it's Germana. She's decided to return to her job after Barilon's shop goes into crisis. Ezio and Cesare decide to sabotage her, but something goes wrong. Ezio can't sell the shop, but Barilon has the right idea, and the two become partners.

After meeting Lucia, Giulio is officially separated and out of therapy. He decides to celebrate by going camping with Ezio and Cesare, but Barilon, feeling left out, plans to sabotage his outing. Gabriella, who blames Giulio for the end of her marriage to Lucia, never sets foot in the Cesaroni household again, but she misses everyone and pretends to be ill to have them around again.

After the trip to Misano, Walter and Alice have grown closer, but both are afraid to declare their feelings for the consequences it would have on their respective families. Only Palmiro, the old mechanic at the garage, urges Walter to take the plunge, and it is Palmiro who, tragically, brings the two together.

Since Giulio has been single, he's always on edge. Ezio and Cesare realize he needs to get back on track. The three embark on a series of tragicomic attempts to meet women. When all seems lost, Giulio meets Gianna. Ezio and Cesare have a hand in it, but have they made the right choice?

Since he's been seeing Olga, Giulio has been constantly away from home, attending exhibitions and events she organizes. Stefania and Pamela urge their husbands to be less of a couch potato. Ezio and Cesare then infiltrate an exclusive party Olga is hosting at a golf club, resulting in a series of hilarious incidents and misunderstandings.

Giulio is furious with Walter and Alice and their secret affair. So are Ezio and Stefania. Marco and Eva, on the other hand, are disappointed: they expected more honesty from their best friend and sister. Furthermore, Walter, under the stress, breaks a key part of the motorcycle he was modifying.

The fire at the garage and motorcycle throws Walter into a panic. Walter is drawn dangerously into the world of horse racing. Luckily, this is the right time for Ezio to bury the hatchet and act like a father. Olga and her children have a problem at home and turn to Giulio for help.

Marco and Eva don't know who to trust with Marta: Alice is on a trip with Rudi and the others, Gabriella is away, and Giulio is always out with Olga. Ezio and Cesare step forward: however, the two decide to enter the girl in a competition at Cinecittà, encountering a series of comical complications that spiral into tragedy when they lose the child.

Marco and Eva, after the shock of Marta's disappearance, realize they've spent too much time at work and too little time with their family. They decide to treat themselves to a relaxing day at the beach. But Marco has a secret that's making him feel bad, and it will come out, upsetting his relationship with Eva. Walter and Carlotta also face a moment of truth: they love each other. She leaves her husband, and he leaves Alice, who, however, doesn't know about Carlotta.

Olga finally makes herself heard, but she has no intention of returning. She entrusts the children to Emma, with Giulio willing to keep them at his house. Furthermore, the two, aided by Ezio and Cesare, must cope with a birthday party Olga was supposed to organize, which will have unpredictable outcomes. Marco is devastated: Eva has gone with Marta to Venice to visit Lucia.

Marco gets a setback from his record company: his album isn't well received. He spirals into self-destruction. Alice is heartbroken over the end of her relationship with Walter. To cheer her up, Jolanda throws her a party, which, however, goes haywire.

No one is willing to play in the traditional match against the San Paolo neighborhood: neither Marco, who is increasingly depressed, nor Lorenzo, who is busy trying out for a professional team. Ezio, Giulio, and Cesare, convinced they'll win anyway, are forced to enlist some of the girls, including Regina, Jolanda, and Miriam.

Emma is scheduled to attend a conference on stalking, and Ezio and Cesare become convinced that she's being stalked by a maniac. The man is actually Flavio, Emma's ex, who has resurfaced. Giulio helps the therapist win him back, but is their closeness merely friendship?

Stefania and Giulio offer to host two Argentine students for a few days: David, whose good looks upset the principal, and Pedro. Miriam tries everything she can to lure Alice into David's arms, just to keep her away from Rudi. Emma, after dismissing Flavio, admits to Stefania that she's in love with Giulio, but the relationship scares her and threatens to jeopardize her therapy with a patient who's threatening suicide.

Lucia stayed in Rome to organize an exhibition of young emerging painters. Rudi returns from vacation convinced he's forgotten Miriam.

Ezio and Cesare, certain they're in contact with aliens, become convinced the world is about to end and decide to steal a submarine to save themselves from the Great Flood. For Giulio, however, the most important thing is to make a good impression on Lucia. While Alice and Rudi grow increasingly cold, Diego meets Miriam, and they immediately fall in love. Giulio finds himself dealing with a young suitor who, because of Ezio and Cesare's intervention, threatens to report him in revenge for being rejected. Lucia's intervention brings the girl to her senses, and Giulio, happy at his newfound connection with his ex-wife, can only be stunned when she announces she's about to return to Venice.

Giulio, Cesare, and Ezio clash with Stefania and Lucia over the assignment of the former Barilon store, where the men want to open a Roma Club and the women a bookstore. In a clash where the ends justify the means, Giulio, seeing the bookstore as a reason for Lucia to stay in Rome, boycotts his friends. Cesare discovers he has a son, the result of a sperm donation he made in his youth. However, things aren't as they seem, and this time, Cesare's enthusiasm will suffer the consequences. To finance their fashion project, Alice and Jolanda decide to find work as waiters, which is how they meet Francesco.

Ezio decides to buy an old Alfa Romeo Arna, so he convinces Cesare and Giulio to take a trip to Sicily to pick up the car. Fueled by Cesare's prejudices against the island, the three become convinced they're staying with a mafia family. Meanwhile, Lucia is forced to confront her jealousy: seeing Giulio in a costume on the front page of a neighborhood calendar is quite disturbing to her.

Cesare is convinced that Flaminio Maphia plagiarized a rap song he composed in his youth with Giulio and Ezio and their group, "The Gladiators." To prove to everyone that the current hit, "Rome by Night," is his creation, he decides to reunite the band. Giulio and Ezio, however, are too rusty to play, and Cesare decides to fend for himself. Ezio, Giulio, and Cesare decide to kidnap Lucia so that Giulio can prove his courage by saving her and at the same time cast a bad light on Fabrizio, Lucia's boyfriend. The mechanic's plan, however, goes awry, and the three end up in a world of trouble. Alice and Jolanda, despite initial difficulties, receive an order for their clothing.

Cesare tells Mimmo that he has to write an essay on the origin of the surname of the mythical Cesaroni family, which dates back to the Roman Empire, where Cesare's ancestor ran a tavern, and Giulio's ancestor was a brave soldier.

To resolve a dispute over Giulio's house, the trio decides to travel to Milan to meet their cousin Flavio Cesaroni. Ezio and Cesare, convinced that Flavio is a financial genius, allow themselves to be drawn into a large investment, mortgaging Giulio's house.

In Garbatella, Blind People's Day is being celebrated, and Sonsei, having become blind out of necessity, frames the Cesaronis by cheating them as usual. Meanwhile, Marco, with Francesco's help, decides to force fate for once and declare his love to Maya. Meanwhile, Mimmo decides to pose as Justin Bieber to help Belinda and thus teach Matilde a lesson. Cesare and Ezio find themselves at loggerheads over Walterino, the Masettis' hamster. To resolve the matter, the two friends are forced to turn to the Forum court. Marco and Maya are finally together and can enjoy their romantic idyll, even though Maya knows she'll have to tell Marco the truth sooner or later.