The search for a missing priest leads detectives on a multi-state manhunt for a suspect who may be the only person with the answers to his whereabouts.

When a 25-year-old college student vanishes on Christmas Eve, investigators must piece together the details of a first date gone tragically wrong.

Investigators search for the mystery killer after a man and woman are found shot on the side of the highway, and they find a break in the case when a deputy comes across the victim's missing car filled with guns and silencers.

After the dismembered remains of a missing woman are found in a freezer, investigators uncover a love triangle and a murderous conspiracy to conceal the truth.

When an 85-year-old man passes away after years of failing health, authorities quickly rule it a natural death and close the case; years later, a bombshell recording reveals that those closest to him may have played a hand in his passing.

When an otherwise healthy young woman is admitted to the hospital with sudden organ failure, an anonymous tip leads authorities to investigate a pattern of unexplained deaths in her family and a shocking prime suspect.

A series of random nighttime shootings has the city of Phoenix on edge as police try to end the reign of terror and interrogate two suspects.

After 22 years, a local news story reignites a decades-old cold case, leading investigators to question a close-knit circle of friends who they believe are hiding the truth about the disappearance of a 25-year-old man. Can investigators convince the group of friends to reveal who the killer is and finally get justice for the victim?

When a 70-year-old grandmother passes away suspiciously on a road trip, investigators uncover a sinister murder plot while searching for her remains.

Investigators question the mother of a deceased baby and her estranged husband to determine how the child died and ended up in a cardboard box, and as they search for answers, they determine who is responsible for the awful crime.

Investigators respond to a local hospital where an elderly woman fights for her life after a brutal assault; the victim is able to describe the vicious assault; quick detective work points the officers to a suspect, but he stonewalls detectives.

After a successful businessman is brutally strangled, investigators become suspicious of his widow and her secret friend.

After decades on the run, a serial killer faces tough questions in the interrogation room and after a woman is found dead in the middle of the road, the finger pointing begins when three suspects are interviewed.

In 2012, 26-year-old Timothy Rambo Ramsey is killed in a drive-by shooting, but the investigation yields little evidence, and the case goes cold for six years; when detectives re-examine the evidence, they uncover a violent feud between two men.

In a story that gripped the nation, three Cleveland women are rescued ten years after vanishing from the city's streets; authorities must confront the man at heart of this notorious crime to unravel the sinister details surrounding the abductions.

A small Ohio town is shaken in 2010 when Tina Herrmann, 31, Stephanie Sprang, 41, Sarah Maynard, 13, and Kody Maynard, 11, mysteriously vanish. Investigators find the family's home covered in blood but very few clues. A tiny detail helps authorities track down a suspect, but they need answers from him before time runs out.

Authorities investigate when an art teacher is killed in her own home, and they bring her husband and a growing list of suspects into the interrogation room to face hard-hitting questions in the hopes of learning why the teacher was murdered.

Detectives rush to find a missing girl who was staying with a murder victim, and as they investigate the dramatic situation, a familiar name becomes a prime suspect, so they interrogate him in the hopes of finding the girl alive.

After a woman is brutally murdered just a week before her wedding, detectives interrogate three possible suspects, including her fiance.

A woman goes missing and interrogators have tough questions for the friend she was last seen with.

A woman is murdered by the foster daughter she took in. But an open-and-shut case becomes more complicated as evidence emerges that the foster daughter may not have acted alone.

After a woman goes missing, a married Navy police officer contends with tough questions about his romantic relationship with the victim; after a decade on the run, officers interrogate the wife accused of murdering her husband.

Detectives put pressure on their prime suspect as they investigate the shooting death of a U.S. postal employee to determine if the killing was intentional or if the postal worker's death was actually an accident, as the suspect claims.

Investigators wonder if a nurse's aide may be a serial killer after several mysterious deaths occur at a VA hospital located in West Virginia.

A man becomes the prime suspect in a murder investigation after finding his partner brutally murdered.