A small Ohio town is shaken in 2010 when Tina Herrmann, 31, Stephanie Sprang, 41, Sarah Maynard, 13, and Kody Maynard, 11, mysteriously vanish. Investigators find the family's home covered in blood but very few clues. A tiny detail helps authorities track down a suspect, but they need answers from him before time runs out.

Authorities investigate when an art teacher is killed in her own home, and they bring her husband and a growing list of suspects into the interrogation room to face hard-hitting questions in the hopes of learning why the teacher was murdered.

Detectives rush to find a missing girl who was staying with a murder victim, and as they investigate the dramatic situation, a familiar name becomes a prime suspect, so they interrogate him in the hopes of finding the girl alive.

After a woman is brutally murdered just a week before her wedding, detectives interrogate three possible suspects, including her fiance.

A woman goes missing and interrogators have tough questions for the friend she was last seen with.

A woman is murdered by the foster daughter she took in. But an open-and-shut case becomes more complicated as evidence emerges that the foster daughter may not have acted alone.

After a woman goes missing, a married Navy police officer contends with tough questions about his romantic relationship with the victim; after a decade on the run, officers interrogate the wife accused of murdering her husband.

Detectives put pressure on their prime suspect as they investigate the shooting death of a U.S. postal employee to determine if the killing was intentional or if the postal worker's death was actually an accident, as the suspect claims.

Investigators wonder if a nurse's aide may be a serial killer after several mysterious deaths occur at a VA hospital located in West Virginia.

A man becomes the prime suspect in a murder investigation after finding his partner brutally murdered.

A young woman's body parts are found in a suspect's plumbing and freezer and when he's brought into the interrogation room, his bizarre behaviour stuns even the most seasoned detectives.

After a 20-year-old man is crushed by a truck that fell off its jack, the victim’s father is brought in to face questions over whether it was really an accident…or murder.

A man is gunned down outside a local shop and authorities interrogate two of his acquaintances to find out which one of them pulled the trigger. Plus, the shocking interrogation of a woman accused of mowing down two children with her car.

A man’s body is found in a wooded area and the victim’s neighbor is brought into the interrogation room, where evidence mounts even as he’s being interviewed.

After a young father is brutally beaten and left to die on the side of a road, four acquaintances are interrogated separately and the finger-pointing begins.

A young man accused of killing a beloved 52-year-old woman changes his tune after a cigarette break and DNA technology helps detectives solve a decades-old murder mystery.

After three members of a Minnesota family are shot by an intruder, leaving only one survivor, a neighbor is brought into the interrogation room for some tough questions.

Authorities question a woman who traveled with serial killer about whether she was a victim or an accomplice. Plus, a bone-chilling confession from a man who freely admits to killing a college student.

A prolific serial killer’s confession in the murder of a young woman turns out to be a hoax but decades later a more likely suspect is ready to talk, under one condition.

Ten years after a young mother allegedly abandoned her family, her mother-in-law reveals a shocking secret: she believes both of her daughter-in-law's lovers murdered her.

After police respond to an apparent suicide, the case takes an unexpected turn when investigators cannot find a gun near the body.

After an 80-year-old woman vanishes, local police and the FBI team u in the pursuit of a suspected serial killer.

When a young woman vanishes, detectives zero in on her controlling estranged husband - whose story continually changes in the interrogation room.

A mother from Florida vanishes into the night after celebrating her daughter's first birthday; in their search to find her, the police seek answers from the father of her child.

When police pull over a local man for violating his parole, the case takes a shocking turn when he suddenly confesses to multiple brutal murders.