The search for a missing priest leads detectives on a multi-state manhunt for a suspect who may be the only person with the answers to his whereabouts.

When a 25-year-old college student vanishes on Christmas Eve, investigators must piece together the details of a first date gone tragically wrong.

When a 70-year-old grandmother passes away suspiciously on a road trip, investigators uncover a sinister murder plot while searching for her remains.

Investigators search for the mystery killer after a man and woman are found shot on the side of the highway, and they find a break in the case when a deputy comes across the victim's missing car filled with guns and silencers.

After the dismembered remains of a missing woman are found in a freezer, investigators uncover a love triangle and a murderous conspiracy to conceal the truth.

A series of random nighttime shootings has the city of Phoenix on edge as police try to end the reign of terror and interrogate two suspects.

After 22 years, a local news story reignites a decades-old cold case, leading investigators to question a close-knit circle of friends who they believe are hiding the truth about the disappearance of a 25-year-old man. Can investigators convince the group of friends to reveal who the killer is and finally get justice for the victim?

After a successful businessman is brutally strangled, investigators become suspicious of his widow and her secret friend.

After decades on the run, a serial killer faces tough questions in the interrogation room and after a woman is found dead in the middle of the road, the finger pointing begins when three suspects are interviewed.

In 2012, 26-year-old Timothy Rambo Ramsey is killed in a drive-by shooting, but the investigation yields little evidence, and the case goes cold for six years; when detectives re-examine the evidence, they uncover a violent feud between two men.

Investigators respond to a local hospital where an elderly woman fights for her life after a brutal assault; the victim is able to describe the vicious assault; quick detective work points the officers to a suspect, but he stonewalls detectives.

When an otherwise healthy young woman is admitted to the hospital with sudden organ failure, an anonymous tip leads authorities to investigate a pattern of unexplained deaths in her family and a shocking prime suspect.

When an 85-year-old man passes away after years of failing health, authorities quickly rule it a natural death and close the case; years later, a bombshell recording reveals that those closest to him may have played a hand in his passing.

Ten years after a young mother allegedly abandoned her family, her mother-in-law reveals a shocking secret: she believes both of her daughter-in-law's lovers murdered her.

Investigators question the mother of a deceased baby and her estranged husband to determine how the child died and ended up in a cardboard box, and as they search for answers, they determine who is responsible for the awful crime.

At the scene of a chilling triple murder in Northern Maine, detectives recover DNA evidence that suggests an out-of-town visitor may be behind the brutal crime.

In a story that gripped the nation, three Cleveland women are rescued ten years after vanishing from the city's streets; authorities must confront the man at heart of this notorious crime to unravel the sinister details surrounding the abductions.

After police respond to an apparent suicide, the case takes an unexpected turn when investigators cannot find a gun near the body.

After an 80-year-old woman vanishes, local police and the FBI team u in the pursuit of a suspected serial killer.

When a young woman vanishes, detectives zero in on her controlling estranged husband - whose story continually changes in the interrogation room.

A mother from Florida vanishes into the night after celebrating her daughter's first birthday; in their search to find her, the police seek answers from the father of her child.