The interventionists arrive to Philadelphia's Heroin Hub and meet Nicole, a 39-year-old heroin addict and prostitute, who's lived in the area for five years. Also featured is Janine, a 22-year-old addict whose father just died from a fatal overdose weeks earlier.

Interventionist Donna Chavous must re-think Janine's intervention now that she's in jail. Interventionist Jim Reidy meets with Nicole's family and learns how she ended up on the streets. 38-year-old heroin addict Bill finances his addiction by selling clean needles to other addicts. The city of Philadelphia organizes a mass eviction in Kensington to remove addicts from the neighborhood.

Alana is a recovering heroin addict who's trying to stay sober while maintaining a relationship with her addict boyfriend. Nicole's fianc 's reaction to Nicole getting help throws her whole intervention into question. 28-year-old heroin addict Amanda risks losing custody of her 2-year-old son for good if she can't get clean. On the eve of Bill's intervention, his family receives shocking news about Bill.

After Bill’s arrest, Interventionist Michael Gonzales strategizes with his family on ways to intervene once he’s released from jail. Alana’s mother suspects that Alana may have relapsed and kicks her out of her home. Janine is released from jail and must decide if she’s ready to get clean. Bill’s family intervenes on him outside the courthouse the moment he is released from jail.

Amanda is torn between her addict boyfriend who’s in jail, and her ex-boyfriend, an EMT who is still in love with her. 31-year-old EJ’s heroin use has escalated since his mother’s unexpected death. While in treatment, Nicole and Janine reveal dramatic updates about where they are in their recoveries. Interventionist Heather Hayes leads an emotional intervention on Amanda.

EJ’s lies and deceptions cause a rift in his family, as some continue to enable him while others holds a firm bottom line. Interventionist Ken Seeley intervenes on EJ, who must finally decide if he is ready to accept help and go to treatment. Janine, Nicole, Bill, Alana, Amanda and EJ give final updates about their recoveries and hopes for the future.