As a part of Mother's Day mother-daughter bonding, Kim and her mother Dr. Possible decide to foil Drakken's latest scheme together. Drakken, on his part, is forced to deal with the presence of his mother while he attempts to steal a batch of Syntho-Plasma.

After both Kim and Drakken have been taken captive, Ron and Shego must race to rescue them from the clutches of Warmonga, Warhok, and the other invaders. All of the main characters must now band together to save the planet that they call home.

While trying to stop Dr. Drakken, Kim gets into a fight with Shego in which they accidentally get a microchip attached to each of them that can control their emotions. However, when Ron accidentally picks up the control device instead of Kim’s communicator, he thinks it’s a game and he inadvertently controls Kim and Shego’s moods, in which he puts on romance mode before he and Kim go to school. Ron must now deal with Kim’s sudden advances towards him while trying to determine what he should do about the situation, all the while Drakken is dealing with a suddenly love-stricken Shego.

High school graduation nears for the senior class, but Warmonga's return jeopardizes everything as Team Possible goes through their toughest odds yet to save the planet.

After Kim constantly foils Dr. Drakken’s evil plans, he decides to try to take over the world through his brain washing shampoo “Lather, Rinse, Obey”. However, the shampoo sells horribly and after talking with Shego, he learns that items mentioned in hip-hop music usually sells quite quickly. When his attempts to persuade a star to use his produce in their song, he enters an “American Idol” type contest in order to become a star long enough to make his shampoo sell. However, with Kim on his trail, will she be able to foil his plan once again?

When Shego begins acting very friendly towards Kim and Ron, they investigate and find a comic-book type villain who is trying to conquer Go City with the help of the rest of Team Go.

When Ron is trying to prove he’s old enough to not be forced to sit at the children’s table at a wedding when he realizes that his evil cousin Sean will be there, he decides to find a date so that it would prove he’s old enough to sit at the more mature tables. However, when both Ron and Kim believe they shouldn’t go together because it would be awkward, Ron decides to try to be a bad boy after he sees an episode of “Agony County” on television because he believes they get all the girls. However, when Kim and Ron go to a villain convention in order to see what is going on, Ron and Drakken inadvertently switch personalities when a machine goes awry, causing Ron to become a maniacal madman and Dr. Drakken to become a kind spirited individual, Kim realizes that a bad Ron may be more than she expected.

When Kim discovers that Ron has missed practice and their daily trip to Bueno Nacho, she finds out that television is the reason he has been busy. She manages to get him and they head out to stop Dr. Drakken and Shego to get back the Pan-Dimensional Vortex Inducer, but when his laser goes awry and sucks them into a television world, Ron’s newfound knowledge of television may just prove useful.

Ron steals Kim's supersuit to use in the upcoming football game. Meanwhile, Professor Dementor becomes jealous of the suit and devises a system to control it.

When Dr. Drakken is ordered by his mother to look after his cousin which turns out to be Motor Ed, Drakken and Motor Ed work together to complete a “Doomvee”, which is a Humvee that is full of superior weaponry. Meanwhile, Kim is feeling alone because Ron is spending the weekend with Felix instead of her, which causes her to become desperate because she needs some social interaction. Kim attempts to hang out with Ron and Felix despite the fact that she hates doing whatever they do, but when Dr. Drakken and Motor Ed steal Felix’s wheelchair, they work together to see if they can retrieve his wheelchair back and put an end to their evil plan.

When Kim and Ron go to stop Professor Dementor from stealing from a top-secret research laboratory, Ron inadvertently catches Dementor’s “Bondo-Ball” in his pocket, which he accidentally triggers later that day. When Ron rushes into Mr. Barkin and gets stuck to him, he rushes to warn Kim but discovers that she is already stuck to Bonnie. Now Kim and Ron must work with their enemies while trying to cope with what occurred to them and there’s still Professor Dementor to worry about; but will Kim and Ron gain any insight towards the life of their enemies through the ordeal?

When Club Banana discontinues Kim's mission clothes just as she needs new ones, she is forced to find a replacement for her long worn clothes. Meanwhile, Kim and Ron start looking for colleges while Drakken starts his next plan.

Things get out of control when Ron and Bonnie become the homecoming king and queen. Now Kim has two problems to deal with – a missing computer expert and Bonnie making a move on her boyfriend.

Yori’s sensei has been kidnapped and all evidence indicates that Lord Monkey Fist is responsible for it. Yori comes to Middleton to get Ron, in which Yori and Ron head off to South America to attempt to stop Lord Monkey Fist. However, when Kim starts to grow suspicious about Yori’s sudden appearance in Middleton, she heads after them to get to get to the bottom of their predicament.

Jim and Tim decide to take on the duties of the Middleton Mascot and Ron takes it upon himself to train them. Meanwhile, Drakken is broken out of prison by an alien named Warmonga.

When Kim and Ron go to stop Drakken's latest plot, they accidentily get their brains switched between their bodies. Now they must stop Drakken's plans, and deal with each others lives.

Kim is forced by her dad to join a club for small children that he leads, much to her dismay. Meanwhile, Monkey Fist plans to steal a very special monkey to fulfill a prophecy.

Ron realizes that he is not technically a man yet, but Kim tells him that he is. Meanwhile, Kim and Ron must stop a villian from stealing a special ring.

When Team Impossible demands that Kim cease her duties as a teen hero, Kim is caught between a choice to live a normal life or continue to help save people. However, even should she decide to keep saving the world on a regular basis, can she outmatch three of the highest paid heroes in the world who have everything at their disposal, even their own theme song?

Junior attempts to rob the Tower of London, but accidentally tries to rob a movie set replica. Kim and Ron go to stop them and perform an extreme mid air stunt and the movie set's director offers them a movie, which they happily agree to. Kim now must deal with Heather, an actress who is going to be her in the movie taking her friends, and Ron has to deal with Quinn, an actor who is going to be him in the movie act completely opposite of him. All of this while they have to stop Junior who is out for revenge on the director for not putting him in the movie.

When Señor Senior Junior breaks Shego out of prison to help him get his father a great birthday present, it's up to Kim and Ron to stop them. Meanwhile, Kim urges Ron to get a job after he uses coupons on their date.

Kim investigates a string of celebrity robberies, but comes up empty-handed. Meanwhile, the tweebs enter Middleton High School as freshmen. Ashley Tisdale guest stars.

After discovering Hana walking on the ceiling, Kim and Ron try to get to the bottom of Hana's secrets. Meanwhile, Monkey Fist finds an ally in Yono the Destroyer as he continues his search for the "secret weapon".

During a fight with Drakken and Shego, Kim gets amnesia and loses all of her memories. Ron now takes on the task of getting her back to her usual self. Meanwhile, Drakken comes up with a plan to turn the military into his slaves.

Kim accidently turns Ron into a selfish jerk with a new haircut, all while two new villians begin their new evil hobby.