After both Kim and Drakken have been taken captive, Ron and Shego must race to rescue them from the clutches of Warmonga, Warhok, and the other invaders. All of the main characters must now band together to save the planet that they call home.

While trying to stop Dr. Drakken, Kim gets into a fight with Shego in which they accidentally get a microchip attached to each of them that can control their emotions. However, when Ron accidentally picks up the control device instead of Kim’s communicator, he thinks it’s a game and he inadvertently controls Kim and Shego’s moods, in which he puts on romance mode before he and Kim go to school. Ron must now deal with Kim’s sudden advances towards him while trying to determine what he should do about the situation, all the while Drakken is dealing with a suddenly love-stricken Shego.

High school graduation nears for the senior class, but Warmonga's return jeopardizes everything as Team Possible goes through their toughest odds yet to save the planet.

On their trip to Go City, Ron and Kim come across a villain named Aviarius who is seeking the power of another hero. However, when Kim inadvertently winds up with the a hero named Hego’s powers, she soon learns that the only way to restore what isn’t hers and to help stop a mad man may be to team up with her deadliest foe; Shego.

After Kim constantly foils Dr. Drakken’s evil plans, he decides to try to take over the world through his brain washing shampoo “Lather, Rinse, Obey”. However, the shampoo sells horribly and after talking with Shego, he learns that items mentioned in hip-hop music usually sells quite quickly. When his attempts to persuade a star to use his produce in their song, he enters an “American Idol” type contest in order to become a star long enough to make his shampoo sell. However, with Kim on his trail, will she be able to foil his plan once again?

When Ron is trying to prove he’s old enough to not be forced to sit at the children’s table at a wedding when he realizes that his evil cousin Sean will be there, he decides to find a date so that it would prove he’s old enough to sit at the more mature tables. However, when both Ron and Kim believe they shouldn’t go together because it would be awkward, Ron decides to try to be a bad boy after he sees an episode of “Agony County” on television because he believes they get all the girls. However, when Kim and Ron go to a villain convention in order to see what is going on, Ron and Drakken inadvertently switch personalities when a machine goes awry, causing Ron to become a maniacal madman and Dr. Drakken to become a kind spirited individual, Kim realizes that a bad Ron may be more than she expected.

When Shego begins acting very friendly towards Kim and Ron, they investigate and find a comic-book type villain who is trying to conquer Go City with the help of the rest of Team Go.

In the spirit of the season, Drakken, Shego, Ron, and the Possible family put their differences behind them to share Christmas in the Arctic ... of course, only after several action-packed battles and confrontations.

When Señor Senior Sr. becomes disappointed in the way his son’s villainy is handled, he decides to hire a tutor to ensure his son’s success; which turns out to be Shego. Meanwhile, a hopeless Kim is stuck on Home Economics with Ron but when Ron becomes an expert chef while Kim can’t cook a single thing, Ron is chosen to help Kim out. Can Kim overcome her predicament or is this one sitch that she cannot escape from?

When Kim discovers that Ron has missed practice and their daily trip to Bueno Nacho, she finds out that television is the reason he has been busy. She manages to get him and they head out to stop Dr. Drakken and Shego to get back the Pan-Dimensional Vortex Inducer, but when his laser goes awry and sucks them into a television world, Ron’s newfound knowledge of television may just prove useful.

Ron steals Kim's supersuit to use in the upcoming football game. Meanwhile, Professor Dementor becomes jealous of the suit and devises a system to control it.

When Ron is volunteering to help the elderly by doing tasks for them, Ron is assigned to the house of Timothy North, an elderly man who has sent all volunteers away. However, Ron stumbles across the fact that Timothy North is really The Fearless Ferret, an old superhero who Ron adores; in which Ron is selected to become the new Fearless Ferret but he must keep his identity a secret, even from Kim. Though when The White Stripe comes to fight the new Fearless Ferret, Ron discovers it’s more difficult than he expected; while Kim is busy trying to figure out why Ron is behaving strangely.

When Middleton High School participates in a student exchange program, Ron is selected to go to a school in Japan while a student named Hirotaka is chosen to come to Middleton. Ron finds out that the school he was assigned to visit is a secret ninja school while Kim and Monique eventually start crushing on Hirotaka. However, when Lord Monkey Fist steals the Lotus Blade from Ron’s sensei, it’s up to Ron to save the day; though without Kim’s help.

To help his son's ongoing quest to become a pop sensation, Senor Senior, Senior kidnaps the Oh Boyz band to blackmail the record company. The plan backfires when Ron winds up captured along with the group. The record executive, finding the Oh Boyz' disappearance to be a profit windfall, is in no hurry to help so Kim must find Ron and the others on her own.

Kim catches a nasty cold from the Tweebs, but still accepts a mission to guard a mysterious machine. After Drakken and Shego steal the device, her mother insists that she stay in bed to rest while Ron and then the Tweebs take up her duties. By the time matters are resolved, everybody on both sides of the conflict has caught the cold.

Kim tries to get the confidence to take a boy to an upcoming dance at her school, while Kim's archenemy, Drakken begins his next destructive plan.

On their way to a cheer competition, Ron and the cheersquad get stranded, but Ron soon realizes that the whole thing could be a set up from an old enemy.

Kim and Ron get a part-time job at Bueno Nacho, while Drakken and Shego start a cheese related scheme in Wisconsin

Kim retrieves a ring-like object from a trade, but she soon learns that it is not actually a ring. Meanwhile, Kim wants to go to a party, but Ron wants her to go with him, and her parents with them.

While Kim and Ron are at the Museum, she discovers that one of her ancestors was a thief and she decides to figure out what really happened in order to clear her family’s name. However, after a bunch of bizarre coincidences connects the events on that day with that of Wade and Dr. Drakken’s ancestors as well, she soon believes she may be close to figuring out what exactly happened to cause her ancestor to get framed, though Ron keeps feeling that something about their predicament just doesn’t feel right.

When Dr. Drakken is ordered by his mother to look after his cousin which turns out to be Motor Ed, Drakken and Motor Ed work together to complete a “Doomvee”, which is a Humvee that is full of superior weaponry. Meanwhile, Kim is feeling alone because Ron is spending the weekend with Felix instead of her, which causes her to become desperate because she needs some social interaction. Kim attempts to hang out with Ron and Felix despite the fact that she hates doing whatever they do, but when Dr. Drakken and Motor Ed steal Felix’s wheelchair, they work together to see if they can retrieve his wheelchair back and put an end to their evil plan.

When Kim and Ron go to stop Professor Dementor from stealing from a top-secret research laboratory, Ron inadvertently catches Dementor’s “Bondo-Ball” in his pocket, which he accidentally triggers later that day. When Ron rushes into Mr. Barkin and gets stuck to him, he rushes to warn Kim but discovers that she is already stuck to Bonnie. Now Kim and Ron must work with their enemies while trying to cope with what occurred to them and there’s still Professor Dementor to worry about; but will Kim and Ron gain any insight towards the life of their enemies through the ordeal?

When Club Banana discontinues Kim's mission clothes just as she needs new ones, she is forced to find a replacement for her long worn clothes. Meanwhile, Kim and Ron start looking for colleges while Drakken starts his next plan.

Things get out of control when Ron and Bonnie become the homecoming king and queen. Now Kim has two problems to deal with – a missing computer expert and Bonnie making a move on her boyfriend.

Ron decides to join the cheersquad, which angers Kim. Meanwhile, the countries' top scientists begin to disappear, and Kim's dad appears to be the next target.