After both Ron Stoppable and shallow Camille Léon leave their beloved pets behind during a fight, Rufus and Debutante go on an adventure, playing a little game of cat and mouse, traversing continents, and finding new friends, all to find their respective owners.

When Ron gets a scare when he thinks he is getting fired, his boss suprises him by making him watch his son instead. Meanwhile, Frugal Lucre gets let out of prison, and immediately goes back to Drakken. They soon begin a new plan together, much to Drakken's disgust.

When Dr. Drakken is ordered by his mother to look after his cousin which turns out to be Motor Ed, Drakken and Motor Ed work together to complete a “Doomvee”, which is a Humvee that is full of superior weaponry. Meanwhile, Kim is feeling alone because Ron is spending the weekend with Felix instead of her, which causes her to become desperate because she needs some social interaction. Kim attempts to hang out with Ron and Felix despite the fact that she hates doing whatever they do, but when Dr. Drakken and Motor Ed steal Felix’s wheelchair, they work together to see if they can retrieve his wheelchair back and put an end to their evil plan.

When Mrs. Hatchet discovers that Kim has an overdue library book, KP's cheerleading activities are suspended. Ron realizes that he lost the book, and he has to retrace his steps through the last few missions he and Kim went on to save Kim from...library lock-up!

Kim is forced by Ron to join the race for class president, but when they bring home a spoiled Prince who is in danger, he runs against Kim.

When the mysterious and creepy Nanny Maim begins reverting people into super babies and using them in a world-wide robbing spree, Kim must use her natural baby-sitting skills to save the day.

Kim plans on throwing her cousin Larry a surprise birthday party, but she has to keep him busy until the party is ready. Meanwhile, Dementor enlists the help of his brother-in-law to steal Kim's battlesuit.

It’s career day and Kim expects to be paired up with her mother. However, when Bonnie gets teamed up with her instead, Kim gets stuck with a janitor who seems too dedicated to his job. Meanwhile, Ron gets paired with a secret agent and gets a plethora of unique gadgets to try out. However, with Dr. Drakken stealing a weather machine so he can flood Canada, Kim may just realize that her mentor may be more useful than she first thought.

When Ron is trying to prove he’s old enough to not be forced to sit at the children’s table at a wedding when he realizes that his evil cousin Sean will be there, he decides to find a date so that it would prove he’s old enough to sit at the more mature tables. However, when both Ron and Kim believe they shouldn’t go together because it would be awkward, Ron decides to try to be a bad boy after he sees an episode of “Agony County” on television because he believes they get all the girls. However, when Kim and Ron go to a villain convention in order to see what is going on, Ron and Drakken inadvertently switch personalities when a machine goes awry, causing Ron to become a maniacal madman and Dr. Drakken to become a kind spirited individual, Kim realizes that a bad Ron may be more than she expected.

When Kim discovers that Ron has missed practice and their daily trip to Bueno Nacho, she finds out that television is the reason he has been busy. She manages to get him and they head out to stop Dr. Drakken and Shego to get back the Pan-Dimensional Vortex Inducer, but when his laser goes awry and sucks them into a television world, Ron’s newfound knowledge of television may just prove useful.

Yori’s sensei has been kidnapped and all evidence indicates that Lord Monkey Fist is responsible for it. Yori comes to Middleton to get Ron, in which Yori and Ron head off to South America to attempt to stop Lord Monkey Fist. However, when Kim starts to grow suspicious about Yori’s sudden appearance in Middleton, she heads after them to get to get to the bottom of their predicament.

To prove a point, Ron decides to eat only Bueno Nacho. Meanwhile, HenchCo is holding an auction for a molecular transducer that Kim must stop.

Kim's canon of villainous foes go hunting for Naked Mole Rat when Rufus becomes the carrier of a much-coveted micro-decoder … all while Kim is pet-sitting for Ron.

Drakken and Shego attempt to breach Area 51 with a gigantic poodle while Ron uses the attack to shoot his monster movie.

When trying to save a scientist from Dr. Drakken’s secret arctic base, Kim and Ron are hit with a truth ray which forces them to speak the absolute truth about every issue. Kim soon discovers that this is a huge embarrassment while Ron is enjoying his newfound truth potential, but can they get through the day without causing themselves huge problems?

Ron comes home to unexpectedly find his new adopted baby sister named Hana Stoppable in his room. At the same time, he has to take care of a sack of flour for health class. Meanwhile, Kim and Ron team up with Yori to stop Monkey Fist yet again.

Kim reluctantly takes on the coaching of Jim and Tim's soccer team, and is quickly overcome with competitive spirit. At the same time, Señor Senior, Sr. has similar issues coaching his son through his first "evil scheme."

When a diamond is stolen, all the signs indicate that a Lithuanian Wolfhound breeder named Falsetto Jones is the thief. Kim and Ron enter Rufus into a dog show as a Peruvian Hairless in hopes of confronting Falsetto and getting the diamond back, though will Rufus actually be able to play the part?

Kim, Ron and the Possible family head to Florida to help Kim's grandmother unpack at her new home. Can Kim fight against her grandmother's over-protectiveness? Meanwhile, Drakken and Shego accidentally create an army of old people instead of teens, and Kim's Nana is one of them. Can Kim fight her own Nana?

The weather outside is frightful when evil, toxically-mutated snowmen terrorize Middleton.

When a recent string of thefts cause a global shortage on a certain type of doll, Kim decides to investigate, despite the fact that she already has a lot of extra-curricular duties to perform. When she finds out that the Bebe-bots are back and bent on creating an army of their speedy species, with Bonnie as their queen, Kim must rely on some recently acquired experimental shoes in order to save the world; though that isn’t going to stop her from doing a few of her extra-curricular tasks along the way.

When Kim catches a cold from her brothers before a mission, she soon discovers that it’s hard to save the world when you’re not feeling well. Dr. Drakken and Shego exploit the moment to steal a laser from the research lab Kim is guarding. However, when Kim’s sickness begins to spread, a series of events occurred that not even she could expect.

Kim, hoping not to be landed with Ron as her science project partner, instead gets a brainiac who won’t let her do anything at all. Monique gets Ron and quickly becomes exasperated by his trademark laziness. Meanwhile Drakken charms DNAmy into creating a vicious Komodo dragon.

After a long list of attempts to turn himself into a jock go sour, Ron gets a new chance to compete in the X games when he and Kim are sent to investigate a series of robberies.

While trying to stop Dr. Drakken, Kim gets into a fight with Shego in which they accidentally get a microchip attached to each of them that can control their emotions. However, when Ron accidentally picks up the control device instead of Kim’s communicator, he thinks it’s a game and he inadvertently controls Kim and Shego’s moods, in which he puts on romance mode before he and Kim go to school. Ron must now deal with Kim’s sudden advances towards him while trying to determine what he should do about the situation, all the while Drakken is dealing with a suddenly love-stricken Shego.