After both Ron Stoppable and shallow Camille Léon leave their beloved pets behind during a fight, Rufus and Debutante go on an adventure, playing a little game of cat and mouse, traversing continents, and finding new friends, all to find their respective owners.

When Ron gets a scare when he thinks he is getting fired, his boss suprises him by making him watch his son instead. Meanwhile, Frugal Lucre gets let out of prison, and immediately goes back to Drakken. They soon begin a new plan together, much to Drakken's disgust.

Kim is forced by Ron to join the race for class president, but when they bring home a spoiled Prince who is in danger, he runs against Kim.

Kim plans on throwing her cousin Larry a surprise birthday party, but she has to keep him busy until the party is ready. Meanwhile, Dementor enlists the help of his brother-in-law to steal Kim's battlesuit.

It’s career day and Kim expects to be paired up with her mother. However, when Bonnie gets teamed up with her instead, Kim gets stuck with a janitor who seems too dedicated to his job. Meanwhile, Ron gets paired with a secret agent and gets a plethora of unique gadgets to try out. However, with Dr. Drakken stealing a weather machine so he can flood Canada, Kim may just realize that her mentor may be more useful than she first thought.

To prove a point, Ron decides to eat only Bueno Nacho. Meanwhile, HenchCo is holding an auction for a molecular transducer that Kim must stop.

When the mysterious and creepy Nanny Maim begins reverting people into super babies and using them in a world-wide robbing spree, Kim must use her natural baby-sitting skills to save the day.

Kim's canon of villainous foes go hunting for Naked Mole Rat when Rufus becomes the carrier of a much-coveted micro-decoder … all while Kim is pet-sitting for Ron.

Drakken and Shego attempt to breach Area 51 with a gigantic poodle while Ron uses the attack to shoot his monster movie.

When Kim catches a cold from her brothers before a mission, she soon discovers that it’s hard to save the world when you’re not feeling well. Dr. Drakken and Shego exploit the moment to steal a laser from the research lab Kim is guarding. However, when Kim’s sickness begins to spread, a series of events occurred that not even she could expect.

When trying to save a scientist from Dr. Drakken’s secret arctic base, Kim and Ron are hit with a truth ray which forces them to speak the absolute truth about every issue. Kim soon discovers that this is a huge embarrassment while Ron is enjoying his newfound truth potential, but can they get through the day without causing themselves huge problems?

Ron comes home to unexpectedly find his new adopted baby sister named Hana Stoppable in his room. At the same time, he has to take care of a sack of flour for health class. Meanwhile, Kim and Ron team up with Yori to stop Monkey Fist yet again.

Kim reluctantly takes on the coaching of Jim and Tim's soccer team, and is quickly overcome with competitive spirit. At the same time, Señor Senior, Sr. has similar issues coaching his son through his first "evil scheme."

When a diamond is stolen, all the signs indicate that a Lithuanian Wolfhound breeder named Falsetto Jones is the thief. Kim and Ron enter Rufus into a dog show as a Peruvian Hairless in hopes of confronting Falsetto and getting the diamond back, though will Rufus actually be able to play the part?

Kim, Ron and the Possible family head to Florida to help Kim's grandmother unpack at her new home. Can Kim fight against her grandmother's over-protectiveness? Meanwhile, Drakken and Shego accidentally create an army of old people instead of teens, and Kim's Nana is one of them. Can Kim fight her own Nana?

The weather outside is frightful when evil, toxically-mutated snowmen terrorize Middleton.

When a recent string of thefts cause a global shortage on a certain type of doll, Kim decides to investigate, despite the fact that she already has a lot of extra-curricular duties to perform. When she finds out that the Bebe-bots are back and bent on creating an army of their speedy species, with Bonnie as their queen, Kim must rely on some recently acquired experimental shoes in order to save the world; though that isn’t going to stop her from doing a few of her extra-curricular tasks along the way.

Kim, hoping not to be landed with Ron as her science project partner, instead gets a brainiac who won’t let her do anything at all. Monique gets Ron and quickly becomes exasperated by his trademark laziness. Meanwhile Drakken charms DNAmy into creating a vicious Komodo dragon.

After a long list of attempts to turn himself into a jock go sour, Ron gets a new chance to compete in the X games when he and Kim are sent to investigate a series of robberies.

Chester Yapsby has stolen a top-secret project that is capable of making insects grow to incredible heights. Kim is contacted for the assignment because she never fails to get a job done, though when it turns out that the giant cockroaches bother Kim as she has a personal fear of insects. Ron must help her overcome her fear in order to save the day. Meanwhile, Ron names one of the cockroaches Roachie and decides to keep it as a pet, much to Kim’s chagrin.

When the Fashionistas and Camille team up to steal secret designs from Club Banana, Kim, Monique, and the Fashion Police must stop them. Meanwhile, Ron and Barkin get trapped inside a shipping crate.

When Kim and Ron go on a senior-class trip to a historic seaport, they meet Drakken who has opened an ancient treasure chest and become possessed by a pirate's spirit.

When Ron is assigned to write a paper about his hero, he decides to use Hego as his subject. While helping Hego to fight a new villain, the Mather, Ron gets zapped by a ray that causes everything he touches to explode. Now, an unexpected hero arises to save him.

When Kim is tardy when going to class, she is sentenced to detention. Meanwhile, Drakken and Shego start their next evil plan.

Kim tries to defend her position of head of the cheersquad while she works with a high-strung agent of Global Justice.