Leo discovers three teen super-humans Adam, Bree and Chase, living in a secret underground lab in the high-tech home he shares with his inventor stepdad, Donald Davenport, his mom, Tasha, and Eddy, the "smart house" computer. Leo takes the trio to school, but when they are unable to contain their bionic abilities on campus, Davenport sends them away to a remote secret lab.

Leo finds out that he will be a student at the bionic academy, not a mentor like Adam, Bree and Chase. Chase engages in a battle against a former nemesis and Adam mentors a younger student.

Donald leaves the Lab Rats in charge of the bionic academy while he celebrates his anniversary with Tasha. Leo invites Janelle to the island, but gets distracted by his nemesis, Spin. Spin challenges Leo to a bionic battle. Meanwhile, Adam tells Bob to do all the things he can't do when Donald is around. Bob goes ahead and steals Donald's plane, but he then hits a button that deactivates the auto-pilot. Sebastian and the Lab Rats work together to save Bob. Back at the bionic battle, Leo tries to impress Janelle by battling with Spin. Spin gets the first attack and knocks Leo over. Leo then fights back and hits Spin in the leg. Janelle rushes over to Spin, who is crying, and helps him up. Janelle gets upset at Leo and takes Spin to get a smoothie. It is then revealed that Spin faked the injury so Janelle would spend time with him. Leo tries to prove that Spin is faking it by taking his crutches. Janelle then yells at Leo and carries Spin away. Leo tries again by filming Spin admitting faking the injury, but Spin then smashes Leo's tablet. Janelle walks in and yells at Leo and Spin. Leo and Spin then become her servants and they must give her the vacation that she deserves. Later, Adam uses Donald's jet wing to fly up to the jet and save Bob. When Adam tries re-activating the auto-pilot, the plane begins to fall. Adam helps Bob conquer his fear of heights by jumping out of the jet. Bob takes Adam's parachute and Adam jumps out to try to get it from Bob. At Donald's house, just as Donald finishes setting up the table, Adam and Bob fall through the ceiling. Donald is disappointed with the Lab Rats. Adam confesses and tells him that he wasn't a good mentor. Bob tells Donald that Adam was a good mentor by boosting his confidence. Donald then tells him that his plane was a smart plane that even without the auto-pilot the plane would land itself automatically.

When Adam, Bree and Chase forget to invite Leo to his surprise birthday party, they must make it up to him, so they take Leo into the ultra-cool virtual mission simulator and show him what it's like to be bionic.

When Leo needs help asking a girl to the school dance, Adam and Chase step in to help, but the plan backfires when she falls for the wrong brother. The boys decide to settle their differences on the dance floor and each show off their best moves. Meanwhile, Bree gets to know her crush, but he gets to know her glitche

The trio has switched places with robot versions of themselves, sending the robots to the remote lab. Tasha is afraid of Leo's attachment to the 'robots' and convences Donald to send them to the scrap yard. Leo heads off to rescue his new friends. On their return home Donald agrees to let them stay and learn about normal human life if they and Leo can keep their bionic powers a secret.

On the Lab Rats' first day of school, all goes awry when Chase is confronted by a football player and his "Commando App" is triggered, transforming him into Spike, an unruly drill sergeant. When Spike defies the school principal, she pits the Lab Rats up against the football team to battle it out for the coveted cafeteria table

The Lab Rats get their first mission to stop Davenport's hi-tech super fast train from speeding out of control.

When Davenport's prized invention, a super strength and laser empowered exoskeleton suit, malfunctions, after Chase reverses its controls, to get back at Leo for stealing his presenting job. However, it ends up unleashing destructive power on the household, making Leo's grandma even more suspicious of the family.

When Chase refuses to admit that Adam has good ideas Adam decides to run against him for student of the semester. Meanwhile, Leo takes advantage of Bree's super speed and starts using her as his personal taxi.

Douglas creates a device that makes any bionic human as smart as Chase. After Douglas tests it on Bob, Bob starts spending time with Chase. This leaves Adam in envy. Meanwhile, Perry made the island officially her own, which makes Bree and Leo angry at her.

Donald and Douglas reveal that they have built an upgrade for all the students bionics, except for Leo's. But the upgrade doesn't work on Adam, Bree, and Chase because their systems are older. Adam, Bree, and Chase are therefore left at their level, while all the students are much more powerful. Meanwhile, Daniel is brought to the Academy because he had been using his bionics in the outside world. Douglas decides to enroll Daniel at the Academy, and he makes Leo his mentor. Leo steadily tries to teach Daniel, but Daniel proves to be unteachable, so Leo gives him the upgrade as well. The students steadily start to vanish, including Daniel. Giselle Vickers, Douglas' old girlfriend, is revealed to have captured them. Daniel sends a video message to the Island, requesting help.

Leo & Adam team up for the school fitness challenge expecting Adam's bionics to be his secret weapon; the plan backfires when they end up going head-to-head in the finals. Meanwhile, Bree and Chase use their bionic abilities against one another.

Leo borrows Davenport's helicopter to take Janelle on a daring date. Bree gets her own room and Adam and Chase are excited to have a room to themselves. But things get out of hand and Chase divides the room up.

Future Leo travels back in time to tell Leo, that Chase, Bree, and Adam won't make it to the future, and Leo is the only one who can save them.

Adam, Bree and Chase switch their bionics but things end up not the way they think when they can't handle it anymore.

Leo is left alone to care for the Lab Rats, but things quickly go wrong when he plays with a new gadget that glitches Adam, Bree, and Chase.

Adam, Bree and Chase learn about chores and earn allowance for the first time. To raise more money, they host a yard sale and accidentally sell an antique jewelry box that Davenport was restoring for Tasha.

Tasha takes the entire family on a nice 'tech free' beach weekend in the RV, but when Davenport discovers a solar flare headed in the Earth's direction, he secretly enlists the help of the Lab Rats.

In order to fight Trent's bullying, Leo signs up for a one-on-one basketball game against his rival.

When Leo accidentally messes up Eddy, an evil demon Teddy replaces him.

Adam, Bree, and Chase are caught on Principal Perry's surveillance camera using bionics.

Leo is blamed for breaking Marcus' guitar.

Chase accidentally discovers that he has a hidden ability - telekinesis.

Adam, Bree, and Chase sneak out to meet Marcus in Davenport’s new self-driving sports car. When Leo tries to stop them, his nemesis Marcus traps him inside the car and programs it to take him on a wild, high-speed ride bound for the bottom of the Pacific Ocean.