Nash has to deal with the fact that Joe may have 72 hours to live after being exposed to a deadly virus while Nash & Joe investigate a drug theft from a research lab.

Nash and Joe trail two brothers who are heirs to a Mafia family. Nash becomes suspicious when he discovers Kelly once had a relationship with the younger brother.

When a reporter is murdered while covering the new ""French Connection"", Nash comes face-to-face with a startling revelation - his brother, a Vietnam MIA, thought dead for the last 24 years, may be alive and in San Francisco. Meanwhile, Lisa's sister, Lynette, arrives to house-sit at Lisa's indefinitely.

Lisa witnesses a murder, but when Nash shows up to investigate there's no evidence of a crime, not even a body. Nash and Lisa team up ala ""Manhattan Murder Mystery"" to investigate.

As a result of a pension dispute, Joe Dominguez is forced to rejoin the force, and he and Nash track down a heroin dealer.

On the way to an undercover purchase of some heavy industrial equipment from some Russian gangsters, carrying $300,000 of the city's money, Inspector Harvey Leek vanishes. Has there been foul play? Or has Harvey pocketed the money? Nash Bridges has to find him before it's too late.

On the day that Nash plans to take a belated honeymoon to Hawaii with Kelly, a high priority police case unravels, putting him on the trail of the betting book of San Francisco's most notorious bookie and a renegade FBI officer who's #9 on the Most Wanted List.

Nash investigates a judge's murder, and unwittingly triggers an Internal Affairs investigation. The Internal Affairs cops go bad, and only Nash Bridges and the SIU can stop them.

A first-rate professional robber and his crew hit San Fran in a string of strong-arm jobs. Joe convinces Nash to moonlight as a private eye, searching for the SF Giant's short stop's missing car.

A world renowned hit-man has been hired to kill the chief witness in a far reaching drug prosecution. Nash Bridges must stop him. Only problem is, the hit-man turns out to be one of Nash's closest boyhood friends gone bad. Meanwhile, Evan works a stakeout with Bryn and gets sidetracked when he falls in love with a woman living upstairs from their surveillance target.

A people-smuggling ring brings Nash and Joe to the aid of a young man searching for his parents.

Nash and the SIU uncover a counterfeitering group where the money is top-of-the-line Supernote quality. Moving in to bust the group, they discover a fake SIU gang impersonating the police. Cooperation becomes tense as suspicions abound over who and what to trust. In the interim, as Nick gets in over his head financially with his horse costs, Nash reluctantly agrees to work with Joe on an off-duty case searching for a Super Bowl ring. However, Nash and Joe soon find themselves impersonating a gay couple as the case develops differently than Nash anticipated.

Nash and Joe help FBI Special Agent Katz recover a Suburban full of stolen FBI weapons. Joes sets Nash up on a blind date with his nanny.

Nash and Joe follow the trail of a criminally insane mental patient who believes he is the nemesis of Sherlock Holmes. Joe hires a baby nurse who takes over his life.

A sniper terrorizes San Francisco on Halloween as a city-wide Blue Flu forces our SIU detectives to assume beat cop responsibilities. Joe tracks down a hard to find Halloween costume for Lucia.

Nash and Joe risk causing an international incident after British consulate workers fake the death of a convicted killer in order to use him for their own nefarious purposes. Joe resorts to extreme measures in order to get Lucia accepted into an ultra-elite school.

A million dollar bounty on Nash's head triggers an onslaught of attacks by a series of ultimate fighters. Michelle meets ""Mr. Right"" while on a stake out trying to trackdown an Internet rapist. Nash is convinced Cassidy's new boyfriend in gay.

Nash gets involved with Irish terrorists, as well as his ex-wife Kelly (Serena Scott Thomas). Meanwhile, Joe looks after a party-minded Arabian prince awaiting a heart transplant.

Nash and Joe are on the trail of a ruthless gang of thieves threatening to release the lethal nerve gas over downtown San Francisco unless the area is evacuated. Once the area is cleared of people, the criminals plan to move in and rob the banks in the area. Racing against time to capture the criminal mastermind behind this scheme, Nash is surprised to discover that the gang leader is Pamela Smith, a beautiful, brilliant chemist who created the deadly gas. Meanwhile, a mysterious woman appears who claims to be Joe's daughter from a college fertility experiment in which he participated years earlier.

When Nash and Joe investigate the mysterious disappearance of several armored cars and their drivers, they uncover a high-tech, covert crime operation run by ex-Navy Seals. When the robbers kidnap Evan, Nash must lure them out of hiding by staging an armored car delivery. Meanwhile, an off-duty case finds Nash and Joe searching for a star football player's dream girl, whom he spotted in a stadium filled with 65,000 fans but doesn't know. Also, the relationship between Evan and Cassidy intensifies as they struggle to keep their affair a secret from Nash.

Nash discovers his life savings is gone when his accountant invests in a deal cooked up by "Bombshell" Tamara Van Zant. While trying to remodel the bathroom himself, Joe burns down his house and takes Nash up on his offer to move into Lisa's. Nick decides to take scuba lessons.

Nash and Joe are the targets of a bail bondsman, who bails out small time thugs and uses them as assassins. Nash and Joe also open up a new detective agency; Bridges & Dominguez - - their first case is finding the stolen wig of a Cher impersonator. Harvey and Evan's friendship is tested when Evan sells Harvey a faulty washing machine.

Nash and Joe are on the trail of a Prowler who is terrorizing San Francisco and kills a member of Nash's S.I.U. team. When Nick springs for dinner at a Hawaiian restaurant, Joe's son J.J. chips his tooth on a piece of poi; Joe and Nick conspire to get a settlement from the restaurant.

An innocent man is scheduled for an execution. Nash, working the entire case from the 'Cuda, must bring the true killer to justice before the midnight deadline. Lucia's bullying of a schoolmate forces Joe and Inger to attend conflict resolution therapy, which only leads to more conflict.

Nash and Joe are arrested for the murder of three SFPD Investigators. Told in a non-linear style, we slowly unravel a conspiracy trying to frame Nash and Joe. Caitlin Cross is introduced, the newest member of the SIU and Nash's evolving love interest.