A string of deaths at a convalescence home leads the Chief to go undercover as a patient, whose two children (Fran Belding and Ed) hint that they wish he were "no longer their problem". It soon appears that violence and murder are considered due care by certain members of the staff.

Ironside becomes trapped in his office on his own, when a man comes looking for revenge. With Mark at school and Ed dragged to the opera by Eve, the Chief has to improvise a series of defences, whilst his team gradually come to realise that something is very wrong.

Mark's old boxing coach, an alcoholic, is found at the scene of a serious assault, and nobody seems prepared to entertain the theory that he might just be innocent. Mark battles to prove that he has been falsely accused, assisted by the rest of the team, and in the process wins the affections of his law school teacher.

Due to give evidence, the Chief discovers that there is a contract out on his life, and that the chosen killer is a highly dedicated man. Whilst the authorities see only the lethal killer, however, it seems that everybody has another side to their personality.

A parole officer famed for his hard line against drug pushers begins to fear for his life after a shooting. The line of suspects, however, as well as including one of his current clients, also seems to include that client's lawyer, and even the parole officer himself.

The Chief is in the bank when it is robbed by a gang of three men, planning to await the arrival of a payroll delivery truck. The threesome are at odds with each other from the start, and Ironside plans to work on the antagonism between them, but they are wise to his plans and will stop at nothing to get what they want.

A girl thought to have died years previously turns up at the home of her mother just as her brother is found murdered. Clearly somebody is trying to kill the family off, but is it connected to the girl, and is she really who she says she is?

A fruit seller is threatened by a protection racket, who obtain false photographs of her lawyer son in an attempt to coerce her into letting them invest in her business on the docks. The racket has not reckoned on the tenacity of Dora and her son, however; or on her good friend Chief Ironside.

A thirteen year old boy is the only witness to his mother's murder, but finds it hard to co-operate with the Chief, knowing that it was Ironside who put his father in prison. Allowing Marty Jessup a temporary pass is the only way for the Chief to solve the murder and to lessen his conscience at the same time.

A court case is put in jeopardy when it seems that the jury is irrevocably hung over its verdict; until the Chief realises that one member must surely be on the take. He has a race against time to unmask the guilty party, however, before the judge must dismiss the jury and let the defendant walk free.

Mark's graduation from law school coincides with the arrest of a caretaker that he has befriended. Believing the man innocent, he finds the weight of the law stacked against him, and quickly becomes disillusioned with his new career. Should he turn his back on law altogether, though, or should he just find another way to devote himself to justice?

The teenage son of a friend of Fran's appears to commit suicide, however the evidence seems to point in a number of different directions. Did he kill himself, or was it a murder made to look like suicide? Or, alternatively, was a suicide made to look like it could have been murder? The Chief has to unravel the story, but he has little real evidence to help him along.

Mark and his girlfriend come across a murder whilst on a date, but decide to defend the killer when it transpires that he acted in self defence. During the case the pair get married, and Ed decides to move in with the Chief in Mark's place.

An ingenious art theft takes place at Comus Towers Art Museum, and a guard is murdered in the process. Chief Ironside takes the case, but another death is to follow; this time the proprietor of the museum, who is an old friend of the Chief's.

Cars are being stolen in worryingly high numbers, and with the numbers recovered falling dramatically, the signs point to a crooked cop somewhere in the department. Mark is convinced that the cop in question is innocent, but nobody else seems very sure.

When Eve is injured during a shooting, the rest of the team recall their early encounters with her, and the Chief wonders if he was right ever to have encouraged her to join the force. Meanwhile, Ed worries over whether he wants to arrest Eve's attacker, or just kill the man outright.

When a drug pusher is arrested following a spate of botched drug raids he fingers Ironside as a gang informer. Ed is press-ganged onto a team set up to investigate the Chief, which leads to conflict with Eve. Meanwhile Ironside himself seems to be taking the investigation very calmly, which leads to concern all round.

A military-issue fragmentation grenade is used in an attack on two Vietnam veterans, one of whom - a friend of Mark's - is killed. When it transpires that another of the pair's old unit has come under similar attack, the Chief sets out to trap the killer, using Ed in a cunning disguise as bait.

The small daughter of a friend of the Chief's dabbles in witchcraft, and becomes convinced that she is responsible for the death of her parents' landlord. Taking to the case to show her that the truth is otherwise, Ironside discovers that the man arrested for causing the death might be equally innocent.

When a woman crashes her car into the Chief's van after suffering a minor heart attack, doctors discover a bullet lodged in her chest, where it has apparently been for several years. When she claims to have no knowledge of ever being shot, the Chief investigates, and soon links her case to that of an unsolved murder.

A man dies of a heart attack whilst flying his plane, but the town medical examiner, a charmingly eccentric Cuban doctor, is convinced that there was foul play. By chance Ironside and Ed are on their way to visit and soon become involved in his investigations; but between pregnant ducks and volatile banana cocktails they have their work cut out as never before.

A policeman known to Ironside for some years is shot dead whilst on an investigation. The evidence points to him being crooked, but the Chief is determined to prove otherwise.

A local businessman sets up an organized vigilante force to try to clean up San Francisco. When a key member is murdered, it becomes clear that the "Second Force" has got severely out of hand.

A compulsive (and unlucky) gambler is in debt to a local mobster for $32,000. Ironside wants to put the mobster away, but only can if the gambler is prepared to turn state's evidence. The Chief has to persuade him to turn against the man who is offering him a way out of debt. (NB - The second episode to feature original song From The Day You're Born.)

A policeman friend of Ironside and the team is the prime suspect in a murder investigation. Is he really guilty, though, or is the evidence just a little too damning?