An apparently accidental death occurs, but Ed risks his shield on the certainty that it was murder. When Ironside gets on the case a murky tale of murdered ex-servicemen and an old robbery is soon uncovered.

Mark's old boxing coach, an alcoholic, is found at the scene of a serious assault, and nobody seems prepared to entertain the theory that he might just be innocent. Mark battles to prove that he has been falsely accused, assisted by the rest of the team, and in the process wins the affections of his law school teacher.

The work of a quartet of musicians is being pirated, and whilst Ed and Fran are investigating, a member of the group is murdered in front of them. Their investigations lead them into the backgrounds of all those involved at the recording studios where the three survivors work, but all of the possible suspects appear to be friends with the group, and therefore unlikely candidates.

Mark and his girlfriend come across a murder whilst on a date, but decide to defend the killer when it transpires that he acted in self defence. During the case the pair get married, and Ed decides to move in with the Chief in Mark's place.

When Eve is injured during a shooting, the rest of the team recall their early encounters with her, and the Chief wonders if he was right ever to have encouraged her to join the force. Meanwhile, Ed worries over whether he wants to arrest Eve's attacker, or just kill the man outright.

A policeman friend of Ironside and the team is the prime suspect in a murder investigation. Is he really guilty, though, or is the evidence just a little too damning?

A famous baseball player who is an old friend of Ed's begins to receive nuisance mail, which soon turns into something far more sinister. Fearing for his family, he refuses Ed's offers of assistance, and tries to handle the situation alone. Ed has to persuade him to change his mind, before events get out of hand.

When Ed returns from a holiday he finds the Chief missing, and a series of obscure clues pointing to the suggestion that he has been kidnapped. In truth Ironside has been waylaid by an old enemy, a mobster seeking his help to solve a murder, but a gang war is brewing and the Chief needs his team to find him in time to stop it erupting unchecked.

A retired assassin kills the son of a mob chief, and tries to escape town after anonymously leaving his own young son in the care of Chief Ironside. The Chief soon puts two and two together, and figures out who the boy is; but he still has to find the father, before a major league gangster out for revenge can get to him first.

Ed befriends the daughter of the judge presiding over his latest case, only for the girl to come to him in fear for her father's life. It seems she is overreacting to a series of accidents, but events soon suggest her suspicions may be correct; especially after it turns out that her father's new wife has old Underworld connections she thought she had left behind.

A notorious jewel thief named Justin arrives in town at the same time as a shipment of famous jewels arrives for display in a local museum. Ironside must keep the thief guessing about the method of shipment so that the jewels will remain safe; but he is up against a mastermind and there is still an inside man who has to be unmasked.

Ironside is the only witness to a murder, but has to go into hospital for exploratory surgery immediately after the events that he witnessed. The murderer is determined that he should not leave hospital alive, and as the Chief deals with the possibility of maybe one day being able to walk again, his presence in the hospital helps various other citizens right wrongs in their lives. Meanwhile Ed, Eve and Mark deal with their own worries and fears for the Chief as the murder attempts escalate.

An obnoxious talk show host known as ""The Peoples' Voice"" begins to receive death threats, and the Chief is assigned to protect him. Firstly he must overcome his own feelings of dislike for the man, but are those feelings entirely misplaced? Events escalate when the host's wife is killed by a car bomb apparently meant for her husband.

A rich man is murdered, and his man-servant is the prime suspect, until a talkative Mynah bird appears which may just have the solution to the whole case on the tip of his tongue.

An old friend of the Chief's, recently widowed, is hearing strange voices and receiving threatening 'phone calls. She is afraid that she is going mad, but the Chief is determined to prove that this is just what somebody wants her to think.

The small daughter of a friend of the Chief's dabbles in witchcraft, and becomes convinced that she is responsible for the death of her parents' landlord. Taking to the case to show her that the truth is otherwise, Ironside discovers that the man arrested for causing the death might be equally innocent.

Peter Justin, a gentleman jewel thief and old adversary of the Chief's, returns from a five year stretch in San Quentin and is soon back to his old life. When a protégé frames him for a robbery and murder charge the Chief has to prove him innocent, despite his knowledge that another recent robbery is most definitely the work of Justin alone.

The Chief is alerted to the murder of a down-and-out by an ex-cop now living on the streets. The trail soon leads to a long line of false cheques, and an extremely unstable man.

An ex-policeman murders his wife, and sets up a complicated false trail and apparently flawless alibi in order to cover his tracks. The Chief has to find a way to crack the man's seemingly perfect defence, in order to prove that he is guilty.

The Chief's god-daughter witnesses a murder whilst performing in a street-side harlequin show. On the run from the murderer, she and her boyfriend remain one jump ahead of Ironside's team; but there is an added dimension to the case which the Chief cannot at first hope to guess at, and a further reason for his god-daughter's desperate flight.

A young pool hustler is coerced into a contract with a crooked promoter when his brother amasses large gambling debts. The Chief steps in, but can he get through to the brothers in time?

A painting turns up, apparently painted by an old friend of the Chief's who is presumed dead after confessing to a murder. The Chief believes that he is still alive, and innocent, and sets out to find not only his friend, but also a murderer.

Victoria Ironside, the Chief's aunt, is a member of the Tuesday Afternoon Bridge Club. When a fellow member disappears, Aunt Victoria turns to the Chief for help, but what he uncovers turns out to be a very strange and sorry tale.

A local college is plagued by false bomb alerts, and the editor of the campus paper is convinced that leftist militants are responsible. However, when the fourth bomb proves to be real, and a member of the bomb squad is killed, the Chief begins to look in another direction.

After the killing of one of his men, gangland boss Lew Parker puts out a contract on Ironside, which the undercover Ed is forced to pick up. Unable to contact the rest of the team Ed has to go along with the preparations for a heist, but when his cover is blown and he winds up a prisoner, the Chief and co must find the missing links before it is too late.