A string of deaths at a convalescence home leads the Chief to go undercover as a patient, whose two children (Fran Belding and Ed) hint that they wish he were "no longer their problem". It soon appears that violence and murder are considered due care by certain members of the staff.

Ironside becomes trapped in his office on his own, when a man comes looking for revenge. With Mark at school and Ed dragged to the opera by Eve, the Chief has to improvise a series of defences, whilst his team gradually come to realise that something is very wrong.

Mark's old boxing coach, an alcoholic, is found at the scene of a serious assault, and nobody seems prepared to entertain the theory that he might just be innocent. Mark battles to prove that he has been falsely accused, assisted by the rest of the team, and in the process wins the affections of his law school teacher.

Due to give evidence, the Chief discovers that there is a contract out on his life, and that the chosen killer is a highly dedicated man. Whilst the authorities see only the lethal killer, however, it seems that everybody has another side to their personality.

The work of a quartet of musicians is being pirated, and whilst Ed and Fran are investigating, a member of the group is murdered in front of them. Their investigations lead them into the backgrounds of all those involved at the recording studios where the three survivors work, but all of the possible suspects appear to be friends with the group, and therefore unlikely candidates.

A parole officer famed for his hard line against drug pushers begins to fear for his life after a shooting. The line of suspects, however, as well as including one of his current clients, also seems to include that client's lawyer, and even the parole officer himself.

When Eve is injured during a shooting, the rest of the team recall their early encounters with her, and the Chief wonders if he was right ever to have encouraged her to join the force. Meanwhile, Ed worries over whether he wants to arrest Eve's attacker, or just kill the man outright.

A fruit seller is threatened by a protection racket, who obtain false photographs of her lawyer son in an attempt to coerce her into letting them invest in her business on the docks. The racket has not reckoned on the tenacity of Dora and her son, however; or on her good friend Chief Ironside.

A thirteen year old boy is the only witness to his mother's murder, but finds it hard to co-operate with the Chief, knowing that it was Ironside who put his father in prison. Allowing Marty Jessup a temporary pass is the only way for the Chief to solve the murder and to lessen his conscience at the same time.

A court case is put in jeopardy when it seems that the jury is irrevocably hung over its verdict; until the Chief realises that one member must surely be on the take. He has a race against time to unmask the guilty party, however, before the judge must dismiss the jury and let the defendant walk free.

A policeman known to Ironside for some years is shot dead whilst on an investigation. The evidence points to him being crooked, but the Chief is determined to prove otherwise.

An ingenious art theft takes place at Comus Towers Art Museum, and a guard is murdered in the process. Chief Ironside takes the case, but another death is to follow; this time the proprietor of the museum, who is an old friend of the Chief's.

Cars are being stolen in worryingly high numbers, and with the numbers recovered falling dramatically, the signs point to a crooked cop somewhere in the department. Mark is convinced that the cop in question is innocent, but nobody else seems very sure.

When a drug pusher is arrested following a spate of botched drug raids he fingers Ironside as a gang informer. Ed is press-ganged onto a team set up to investigate the Chief, which leads to conflict with Eve. Meanwhile Ironside himself seems to be taking the investigation very calmly, which leads to concern all round.

A string of bank robberies are being committed, all with the exact hallmarks of a certain thief recently released from prison. Having a liking for the ex-con, however, the Chief wishes to believe in his innocence, and sets out to prove that it may be a copycat who is responsible for the raids.

A military-issue fragmentation grenade is used in an attack on two Vietnam veterans, one of whom - a friend of Mark's - is killed. When it transpires that another of the pair's old unit has come under similar attack, the Chief sets out to trap the killer, using Ed in a cunning disguise as bait.

The small daughter of a friend of the Chief's dabbles in witchcraft, and becomes convinced that she is responsible for the death of her parents' landlord. Taking to the case to show her that the truth is otherwise, Ironside discovers that the man arrested for causing the death might be equally innocent.

Ironside is having problems keeping a group of local kids on the straight and narrow, and enlists the help of football star Bat Masterson, an old friend of Mark's. Bat's brother Joe, however, is a rather less savoury character, and Bat has to choose which side he is on.

A local businessman sets up an organized vigilante force to try to clean up San Francisco. When a key member is murdered, it becomes clear that the "Second Force" has got severely out of hand.

A compulsive (and unlucky) gambler is in debt to a local mobster for $32,000. Ironside wants to put the mobster away, but only can if the gambler is prepared to turn state's evidence. The Chief has to persuade him to turn against the man who is offering him a way out of debt. (NB - The second episode to feature original song From The Day You're Born.)

A notorious jewel thief named Justin arrives in town at the same time as a shipment of famous jewels arrives for display in a local museum. Ironside must keep the thief guessing about the method of shipment so that the jewels will remain safe; but he is up against a mastermind and there is still an inside man who has to be unmasked.

A policeman friend of Ironside and the team is the prime suspect in a murder investigation. Is he really guilty, though, or is the evidence just a little too damning?

An old friend of the Chief's, recently widowed, is hearing strange voices and receiving threatening 'phone calls. She is afraid that she is going mad, but the Chief is determined to prove that this is just what somebody wants her to think.

A famous baseball player who is an old friend of Ed's begins to receive nuisance mail, which soon turns into something far more sinister. Fearing for his family, he refuses Ed's offers of assistance, and tries to handle the situation alone. Ed has to persuade him to change his mind, before events get out of hand.

Two killers break out of their cell in the precinct and hold Ironside and Eve Whitfield hostage, forcing the Chief to come up with a fool-proof plan for their escape. As always Ironside has a trick or two of his own up his sleeve.