Max tests a bold new cost-saving program that could help both New Amsterdam and its neediest patients. Wilder struggles with a patient’s decision to refuse life-saving surgery. Reynolds comes to an important realization about his father’s behaviors. Iggy takes the leap into online dating.

Max and Helen adjust to sharing their lives and problems, including the challenge of Helen's mother. Bloom and Reynolds treat a family after their horrific car accident lands them in the ED. Iggy and Trevor reach a new understanding in their business relationship.

Dr. Reynolds and Dr. Malvo have a heart-to-heart with Dr. Baptiste. Max learns a little more about Sharpe when someone from her past resurfaces. Iggy plays referee between two young patients and their families. Dr. Wilder reconsiders Max’s offer to join the staff.

Max mandates a personal health day for the staff at New Amsterdam and meets with surprising resistance. Reynolds finds himself intrigued by a persuasive new member of the staff. Bloom struggles with job stress after being taken off an essential medication. Iggy goes on his first date. Max convinces Wilder to get much needed surgery.

It's National HIV Testing Day and Max has offered free care to all HIV+ patients who come to New Amsterdam. Bloom and Reynolds butt heads over their opposing bedside manners. Iggy eagerly awaits the return of a friend. Sharpe discovers that she may need more hands on with her niece.

Max is on a mission to fix systemic racism at New Amsterdam. Bloom treats a patient who reminds her that things aren't as they seem. Sharpe is overwhelmed while tending to a family matter. Reynolds tries to keep his composure while treating a father and son.

Max reckons with New Amsterdam's past. Bloom and Reynolds treat a patient in an unconventional relationship. Sharpe decides to take a stricter approach to parenting her frustrated teenage niece. Iggy tries to connect with a patient desperate to have gastric bypass surgery.

Max implements sweeping changes to hospital sustainability practices. Bloom returns from vacation. Reynolds treats a young patient with deadly heat stroke. Iggy discovers a dangerous situation with a former patient.

Max is forced to examine the inequities in child labor for women of color. Bloom must deal with an overcrowded ED. Sharpe helps Dr. Agnes Kao with a gut-wrenching diagnosis. Reynolds finds himself experiencing something new on the job.

Max advises a young student at a science fair but encounters legal complications with her brilliant invention. Bloom encourages Dr. Shinwari to be more aggressive in the ED. Iggy gets a lesson in humility. Brantley has a surprise for the staff.

Max struggles with a new fiscal reality at the hospital. Dr. Sharpe is on a mission to provide follow-up cancer screenings for patients before it’s too late. Bloom grapples with Dr. Shinwari’s new overnight schedule. Reynolds has an interesting conversation with Dr. Malvo about their future.

Max and Bloom are shocked when a deadly ambulance crash reveals a dangerous plan. Dr. Fuentes pressures Iggy to take on patients. Sharpe realizes her own cost-cutting has adversely affected her department. Reynolds, Baptiste and Malvo strive to reach an accord.

Max is faced with a wrenching decision when New Amsterdam falls prey to a massive ransomware attack.

Max takes drastic measures to help several undocumented immigrants after a fire destroys the church where had sought refuge; Sharpe and Malvo assist a patient with a life threatening condition; Reynolds is conflicted about his new position.

As Max and Dr. Sharpe prepare to depart for London, a deadly superbug hits the hospital and draws them back in. Leyla confronts Bloom about the secret she has been hiding. Iggy digs deep to help two grieving parents confront the reality that their son is gone.

Max and Helen settle happily into their new life in London. Dr. Fuentes takes over as medical director with disastrous effects. Bloom helps a patient who thinks he’s cursed. Iggy develops a plan to get his psych patients gainfully employed.

Helen takes the reins at NHS Hampstead Hospital while Max gets creative to help a patient in need. Reynolds reaches a decision about Dr. Malvo. Iggy and Bloom help their patients understand the underlying cause of their stress. Dr. Wilder employs more unconventional techniques.

As the team gathers to mourn the loss of someone dear, Max and Helen realize the extent to which New Amsterdam has changed since they left. Bloom struggles with a big decision while Reynolds decides to take his concerns for his patients to a new level. Dr. Fuentes once again reminds the New Amsterdam team who is in control.

Max is on a mission to deliver free broadband access. Reynolds treats a young girl with a gunshot wound. Sharpe gives difficult news to a long-time patient. Iggy is immensely proud of his patient's success but worries that he may be getting too close.

Sharpe offers help to a reluctant Mina. Max is faced with a tough decision about Luna. Bloom and Casey treat a patient who has been hiding a lifelong secret. Iggy finds himself in a very dangerous predicament. Reynolds treats a young heart transplant patient with astonishing symptoms.

Max races against the clock to rearrange the budget when faced with employees going unpaid, while Kapoor is presented with a device that's the future of medicine. Meanwhile, Iggy goes against the norms to prove a diagnosis and Bloom gets an unexpected visitor.

Max and Sharpe wake up to a new, more personal dynamic. Iggy calls upon an old contact to help with an explosive situation at the hospital. Bloom begins a tricky dynamic with her new Emergency Department residents. Reynolds finds himself in an awkward position with Dr. Baptiste and his wife, Dr. Lyn Malvo.

Max and Sharpe go public with their relationship at the hospital. The team struggles to handle an overcrowded and understaffed ICU. Iggy's overly critical feedback alienates his residents.

Dr. Fuentes continues her quest to remake the hospital in her vision. Max goes the extra mile to help a patient in need. Dr. Sharpe and Iggy find themselves at odds over a very serious issue. Reynolds discovers the importance of personal obligations. Bloom comes to a shocking realization about her mother.

When tasked with turning the opioid epidemic around, Max shuts down the ED and proposes a massive change. Meanwhile, Sharpe goes great lengths to prove a point.