Shaun and Lea are heading to the delivery room and everyone from the hospital is also there, except for one very important person. Meanwhile, a tragic accident involving Drs. Perez and Kalu pulls everyone away, including Dr. Murphy.

Dr. Shaun Murphy seeks legal representation to help him win a case and puts his faith in a promising, young lawyer who has obsessive compulsive disorder.

As the doctors consider their futures, they work together to solve one of the most important cases of their careers.

When a patient comes in with persistent and lingering COVID symptoms, the team discovers she may be dealing with something harder to treat. Andrews and Villanueva must contend with their hierarchy at the hospital and its effect on their relationship.

Shaun and Lea happen upon a terrible car accident and discover a young pregnant mother who has been badly injured and needs immediate medical attention. Dr. Glassman is apprehensive when a figure from his past reaches out for help.

Dr. Glassman and Dr. Murphy's relationship may be irreparably damaged following a tense moment during surgery. While Dr. Reznick struggles during her parental leave, Dr. Park may just be the one she needs the most.

Dr. Shaun Murphy and Dr. Alex Park treat two patients who collapse at the local airport and whose symptoms point to an infection that may become airborne. The staff races to contain the infection before it spreads to the rest of the patients in the ER, resulting in a hospital quarantine during the holidays.

As a barroom fight sends Dr. Shaun Murphy to seek treatment at St. Bonaventure’s, Dr. Alex Park and Dr. Audrey Lim disagree over an elderly woman’s post-operative symptoms. Meanwhile, Dr. Neil Melendez and Dr. Lim make their romance public, and Dr. Aaron Glassman continues to pursue a relationship with a good friend.

Shaun and Lea’s long-awaited wedding reception is interrupted by a violent attack at the hospital and the entire team must mobilize to save the victims. Meanwhile, the trauma of seeing people he cares for in life-threatening situations is affecting Shaun in more ways than one.

Dr. Shaun Murphy unknowingly creates a competition between Drs. Danica Powell and Daniel Perez when he introduces a new performance rating system; Dr. Morgan Reznick may have crossed a line with Dr. Alex Park.

Shaun and Lea soon learn that their surprise pregnancy may also come with additional complications. Meanwhile, Doctors Park, Reznick and Allen treat a teen with Gardner’s syndrome whose past surgical history jeopardizes the outcome of his current one.

Dr. Shaun Murphy must learn how to work with Dr. Jared Kalu again and remind him that he must start all over at St. Bonaventure. Meanwhile, Dr. Murphy treats a teenager suffering from neurological problems with a very high-risk procedure.

The team at St. Bonaventure needs to quickly discover the truth behind a young college student’s unexplained injuries before his condition worsens. Meanwhile, after losing his most prized possession, Shaun’s distraction during a surgical procedure may end up risking more than just his job.

Dr. Shaun Murphy is desperate to join the team on a dangerous procedure involving a patient’s tumor removal. However, having been removed from the surgery team by Dr. Jackson Han, Shaun must use his talents to help figure out the cause of an infant’s injuries.

Dr. Shaun Murphy makes a personal connection with a precoious young patient which threatens his objectivity. Meanwhile, while volunteering at a long-term care facility, Dr. Morgan Reznick realizes she could help Dr. Aaron Glassman’s clinic by offering telemedicine services for nursing homes and care facilities.

Drs. Shaun Murphy, Asher Wolke and Aaron Glassman meet a patient with an infected surgical sponge that was left in their abdomen. Meanwhile, Dr. Morgan Reznik must face her own past when she treats the victim of a sexual assault.

Shaun and Lea clash over their parenting styles and worry about what will happen to their relationship when their child is born. Meanwhile, Dr. Lim must find a way to save the damaged lungs that one of her long-time patients has been waiting for.

Dr. Jared Kalu makes a surprise return to San Jose’s St. Bonaventure Hospital with his billionaire patient. Meanwhile, Park must treat the man his wife had an affair with and try to find a way to forgive him.

Dr. Marcus Andrews introduces some of the team to a patient whose optimism and faith seems to cause Dr. Asher Wolke the most skepticism in light of his own relationship with religion.

Dr. Claire Browne returns from her work in Guatemala for a personal medical examination. Elsewhere, Dr. Glassman struggles to manage Hannah, who remains unresponsive to his attempts to help. Park seeks out the perfect last-minute wedding location.

The hospital is still in quarantine as Dr. Shaun Murphy continues to be overwhelmed by the chaos and noise in the emergency room; Dr. Morgan Reznick struggles to keep her patients alive, and Dr. Audrey Lim fights for her life. Meanwhile, Dr. Neil Melendez and Dr. Claire Browne must find a way to complete their patient’s bone marrow transplant, despite the quarantine.

The staff of St. Bonaventure Hospital works against time and their own personal safety to save the lives of those around them.

In the midst of a heatwave, Dr. Shaun Murphy and Dr. Danica Powell are at odds when it comes to their patient’s surgery. Their heated stalemate tests Shaun’s patience and his willingness to compromise. Meanwhile, when the hospital loses power, Lea and Dr. Aaron Glassman are forced to come up with a quick solution or risk a total shutdown that could risk patients’ lives on the 100th episode.

On the way to their babymoon, Lea and Shaun get a quick lesson in parenting when they rush to aid an injured dog. Meanwhile, Dr. Danica Powell secretly performs an operation on a friend that could jeopardize her career.

Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join the prestigious St. Bonaventure hospital’s surgical unit. Alone in the world and unable to personally connect with those around him, his only advocate, Dr. Aaron Glassman, challenges the skepticism and prejudices of the hospital’s board and staff when he brings him in to join the team. Shaun will need to work harder than he ever has before, as he navigates his new environment and relationships to prove to his colleagues that his extraordinary medical gifts will save lives.