While working in his basement, Quinn Mallory opens the gateway to parallel worlds. For a test run, Quinn invites co-worker Wade Welles and his teacher, Professor Arturo, along. Upon opening the vortex, Quinn uses too much power, which causes the vortex to suck them in along with Rembrandt "Crying Man" Brown, who happened to be driving by Quinn's house. The four arrive on a world that experienced an ecological disaster and will have to survive until the timer hits zero.

When the Sliders land on a seemingly ideal world, Wade wins the lottery. But Quinn discovers that the lottery is population control and the winners are killed.

After separating from Ryan and Henry the dog, the Sliders make a rough landing that reopens Quinn's bullet wound. On this world of mysticism and superstition, a witch doctor heals Quinn and has brains on the mind when they can't pay the bill. On the run from bounty hunters, the Sliders only hope is the mysterious Sorcerer, a man who could possibly get them home.

The Sliders have come to the most unexpected world of all... home. While Rembrandt and Wade use their sliding adventures to kickstart their careers, Arturo steals the timer and claims sliding as his invention. However, Quinn remains convinced they are not home.

The Sliders become involuntarily apart of a human war game where the only winners are the ones that stay alive.

On a world quickly running out of natural resources, Rembrandt meets his number one fan but finds her to be a little too friendly. Meanwhile, Quinn and the others meet Logan, a scientist at Prototronics that's trying to develop sliding. However, they learn her plans for sliding are far from noble.

The Sliders arrive on a world that will be destroyed by an asteroid before they are due to slide. Arturo works with Bennish to develop an atom bomb to destroy the asteroid and Rembrandt gets caught up in an end of the world celebration, while Quinn and Wade confront their feelings for one another.

The Sliders land in the middle of a strange invasion and Quinn uses the timer to bring down one of the ships. Before barely escaping, the Sliders learn these new villains can slide at will and are soon captured on the next world. They learn their captors are the Kromaggs and are intent on conquering every parallel world.

Quinn, Rembrandt and Maggie land on a world where the United States is run by the Oracle, a blend of fundamental beliefs and right-wing conservatism. Followers trade their wealth and possessions in return for passage to a nirvana world, but the Sliders discover the Oracle's portal is a deadly sham.

On a world where penicillin was never invented, Quinn is mistaken for his double, who is believed to be the cause of a massive epidemic. While he is imprisoned by a health agency, Wade shows signs of being infected and only Arturo can find the cure.

On a world where being smart is the equivalent of being a sports star, Quinn is a popular college athlete and finds his double had underhanded dealings with gangsters. Meanwhile, Arturo discovers his late wife is alive on this world and tries for reconciliation after learning she is pressing for divorce.

Rembrandt has arrived on his dream world, where his double is as popular as Elvis, but has been dead for eight years. As Rembrandt gets to enjoy the fame he's long since wanted, an old enemy plots to make sure he disappears for good.

The Sliders arrive on a world where roles are reversed with women holding the positions of power. Arturo becomes a candidate for the mayoral race in San Francisco, trying to bring about a "men's rights" movement.

The Sliders arrive in the British States of America, where Arturo's double is plotting to assassinate a prince and take the throne. When the Sliders inadvertently foil the plot, they come into contact with a group of rebels trying to bring freedom to America.

On a world where a biological weapon wiped out most of the male population, Quinn, Rembrandt and Arturo become objects of desire and are imprisoned by the government to be breeders. As they try to escape and regroup with Wade, they find there are others out to capture them.

A lightning bolt strikes the vortex during a slide, damaging the timer and trapping Quinn on the astral plane. Now the Sliders are stranded on a world with 1950s technology and Quinn can not be seen by the others. He tries to get the help from the only one who can see or hear him, a girl that has a history of hearing voices.

On a world where everything west of the Mississippi is part of the Nation of Texas, corporate lawyers carry gunslinging ways of the Old West. After Quinn gets mixed up in a showdown, he gains the reputation for fastest draw in San Francisco and tries to prevent the hostile takeover of a family-owned computer company.

The Sliders find themselves running into the same people on each new world, one of them being Quinn's former love, Daelin. After encounters on worlds where the Spanish rule America and Daelin is an abused wife, the Sliders arrive on a world where time moves backwards and they are accused of Daelin's murder. Quinn wants to save her, but it could have disastrous results.

The Sliders arrive on a world just like their own, only time is moving at a rate of twelve years slower than normal. There, Quinn encounters his young double and tries to change an upcoming event in his life, despite the other Sliders' warnings.

On a world where the legal system is in the form of televised game shows, Quinn is arrested, tried and sentenced to death for the crimes of his double.

Things don't look good for the Sliders when they slide to a world that's about to be eradicated by a rogue pulsar. Soon they discover that this world has been developing sliding technology and pool their resources with the U.S. government in a race to escape to a parallel Earth.

Quinn and Maggie return to her world with Earth Prime's coordinates stored in Jensen's timer. As Wade makes the final list for those who can slide to safety, Arturo races to modify the new timer to slide more people. Unfortunately for them, an unexpected danger lurks the base and one Slider will not make it to the next world.

The Sliders slide into a Kromagg weapons-testing area and Maggie saves the life of the Kromagg commander, Kromanus. While Maggie tries to get the timer back from him, Quinn and Rembrandt discover a Kromagg weapon designed to eradicate humans.

The Sliders arrive on a world where virtual reality is a normal part of life. After Maggie is injured in an explosion, she awakens in a hospital to find they have missed the slide. The only way to go is to build a new timer, but is everything what it seems?

The Sliders track down Quinn's long lost brother, Colin, to a Amish-type Earth. Quinn convinces Colin they are brothers and to slide to find their true home. But on the next world, a double of Colin's former love takes advantage of him and involves him in a scam to steal cryogenically frozen bodies.