The Sliders have come to the most unexpected world of all... home. While Rembrandt and Wade use their sliding adventures to kickstart their careers, Arturo steals the timer and claims sliding as his invention. However, Quinn remains convinced they are not home.

The Sliders land in the middle of a strange invasion and Quinn uses the timer to bring down one of the ships. Before barely escaping, the Sliders learn these new villains can slide at will and are soon captured on the next world. They learn their captors are the Kromaggs and are intent on conquering every parallel world.

A lightning bolt strikes the vortex during a slide, damaging the timer and trapping Quinn on the astral plane. Now the Sliders are stranded on a world with 1950s technology and Quinn can not be seen by the others. He tries to get the help from the only one who can see or hear him, a girl that has a history of hearing voices.

The Sliders find themselves running into the same people on each new world, one of them being Quinn's former love, Daelin. After encounters on worlds where the Spanish rule America and Daelin is an abused wife, the Sliders arrive on a world where time moves backwards and they are accused of Daelin's murder. Quinn wants to save her, but it could have disastrous results.

After separating from Ryan and Henry the dog, the Sliders make a rough landing that reopens Quinn's bullet wound. On this world of mysticism and superstition, a witch doctor heals Quinn and has brains on the mind when they can't pay the bill. On the run from bounty hunters, the Sliders only hope is the mysterious Sorcerer, a man who could possibly get them home.

On a world where a biological weapon wiped out most of the male population, Quinn, Rembrandt and Arturo become objects of desire and are imprisoned by the government to be breeders. As they try to escape and regroup with Wade, they find there are others out to capture them.

While the Sliders wait to leave a world of violence, Quinn saves a woman named Michelle from her criminal boyfriend, Sid. Sid then goes after the Sliders through the vortex, where they all arrive on a world where San Francisco is a maximum security prison.

The Sliders land on a world where San Francisco is a national park dedicated to the preservation of dinosaurs, which is home to a deadly Allosaurus. A bad fall causes Arturo to injure himself and lose the timer. Quinn goes out alone to search for it, while the others hide out from the Allosaurus in a cave.

On a world where Prohibition was never repealed, Rembrandt's double is famous for fighting crime and corruption. Unfortunately, the trouble starts when the Sliders land in the middle of a wedding, where the groom and bride are from mob organizations.

The Sliders arrive on a world where the young are in charge and Wade and Quinn's doubles were married corporate executives. Quinn winds up posing as his dead double and finds questions in his death. Meanwhile, Arturo and Rembrandt find themselves in trouble with the law and face jail time.

Wade literally meets the man of her dreams, Derek Bond, on a world where ten percent of the population possess psychic abilities. It turns out Derek is a psychic and is next in line for the powerful position of Prime Oracle. But the future gets grim fast as Rembrandt and Arturo become prime suspects in a murder that hasn't happened yet.

Wade witnesses a murder just before the slide, but as the Sliders land on the next world, the same murder is about to occur. This time, Wade intervenes and this gets the Sliders involved with a disgraced federal judge and a United States under martial law.

On a world where everything west of the Mississippi is part of the Nation of Texas, corporate lawyers carry gunslinging ways of the Old West. After Quinn gets mixed up in a showdown, he gains the reputation for fastest draw in San Francisco and tries to prevent the hostile takeover of a family-owned computer company.