St. Eligius' 50th anniversary spurs memories, including: the growing up of Donald Westphall, the arrival of young Daniel Auschlander and his first meeting with Katharine, a drunken and embittered Father McCabe's departure, and the residency of Mark Craig under Dr. David Domedion. The O'Casey family's long history with St. Eligius leads Morrison to a diagnosis. Pete is returned.

Fiscus poses in provocative attire for a newspaper feature; Dr. Caldwell and Joan try to take a spontaneous trip to Paris; Armstrong reacts to the pressures she faces; and everyone waits to hear about who will be dropped from the residency program.

St. Eligius' 50th anniversary spurs memories, including: it's opening in 1935 under the leadership of Father Joseph McCabe, the arrival of recently emigrated Helen Rosenthal and Mark's return as chief of surgery, Mark's bypass on Patrick O'Casey and the death of Maureen Westphall. Morrison struggles to diagnose a difficult patient and cope with the loss of Pete to a kidnapper.

Dr. Fiscus is shot. Afterwards, he experiences the afterlife and meets some old friends. Such people include old patients who died in the hospital, a few in limbo and a couple in heaven. However, he is condemed to hades and finds Dr. White swiming in circles for all eternity in a boat with only one oar. Meamwhile, the docs at St. Eligus try their hardest to keep Fiscus alive.

The Endicotts learn that their family's medical problems are hereditary; Dr. Caldwell prepares for surgery to eliminate his facial scar, but learns that he carries a more permanent reminder of his carelessness; and Fiscus and Morrison play romantic games with Clancy and Mona.

Dr. Craig performs the transplant amidst a publicity barrage; Morrison tries to adjust to his loss; Luther and Fiscus split an investment in silver futures; and Rosenthal counsels a group on breast cancer.

Chandler does his outreach work at a crisis hotline, where he draws a suicide on his first night; Ehrlich earns Dr. Craig's approval after he performs well during an emergency; and Carol Novino renews her friendship with Dr. Westphall and his family. Ellen Craig kicks Mark out of their home.

Morrison tries to help a bag woman and her husband; Fiscus admits a relatively healthy woman who had fainted for some very expensive tests; V.J. feels homesick; and the bomber and his victim both leave the hospital.

A fisherman lobbies Dr. Westphall to let his brother die in peace and dignity; Fiscus substitutes for Ehrlich on a date with Shirley Daniels; and Helen's stress mounts as the hospital suffers computer glitches and she faces a radical mastectomy. Peter celebrates his birthday and runs into Myra and a gentleman friend.

Dr. Craig and Ehrlich both prepare turkeys for the staff forced to work the holiday; injuries from the Thanksgiving Day parade pour into the ER; and a depressed Dr. Auschlander takes a special interest in an ailing 11-year-old.

Joan's father enters the hospital unexpectedly; Chandler takes a practice run for the Boston Marathon that proves dangerous; and the Craigs host Ehrlich's wedding with guests such as Mrs. Craig's mother and Ehrlich's alcoholic aunt Charice.

Three women in a room become close despite their differences; an old woman facing the loss of her independence; a mother trying to deal with violent surges of erratic behavior; and a bland young woman searching for 'character' through a nose job.

The residents scatter as vacation begins; Morrison meets a charming young woman; the E.R. faces major structural repairs; Steven Craig returns home after licking his drug problem; and Luther tries to find a Cheshire cat for a skeptical little girl. Dr. Auschlander collapses in an elevator. Elliot Axelrod has an interview for a position as a resident.

The Craigs meet their pregnant daughter-in-law, Yvonne; the Valeres continue to explore ways of having a child; Westphall's new policies irritate the residents and Auschlander; and Luther rides with a paramedic team preoccupied with their personal grievances.

The Craigs face a tremendous loss as their first grandchild is born; a newly inspired Dr. Westphall returns to work full of ideas; and Fiscus invites himself up to Dr. Caldwell's Cape Cod retreat, where he sees a different side to the surgeon. Elliot and Marcy discover a common interest in food.

Dr. Craig arranges to take Yvonne home to her parents; Ehrlich advises a plastic surgery patient behind Dr.Caldwell's back; Capt. Neal arrives to evaluate the astronaut's condition and to supervise his transfer to Walter Reed, despite Westphall and Morrison's objections; Chandler and Dr. Turner plan a vacation together; and John Doe #6 decides he's Mary Richards and plans a party to celebrate.

The Endicotts try to adjust to losing a family member but gain good news about another; Dr. Caldwell's diagnosis of AIDS causes concern for his friends and a cooling in Fiscus and Clancy's relationship; and Ehrlich's outreach assignment involves the normal sized son of dwarf parents.

Dr. Turner returns to St. Eligius in time to deliver the baby of an old patient; Chandler has very bad luck as he searches for her all day; and Dr. Auschlander is trapped in a crack house that has been bequeathed to the hospital.

The residents worry over who will be asked to return next year; the Craigs worry over the ""Doctor of the Year"" award dinner; Fiscus grows obsessed with opening a locked door; Martin drops by with a new look; Dr. Auschlander fears death as Halley's Comet blazes overhead; and a mugging victim named Boston Massachusetts waits for treatment in the E.R.

A depressed Father Joseph McCabe returns to St. Eligius; Morrison receives a visitor from Seattle; Dr. Craig seeks help for his injured hand from an old classmate; one of Axelrod's patients awakens in the morgue; and Luther plays musical air conditioners.

Martin decides she's in love with Dr. Craig; White regrets helping out an exhausted mother pleading for sedatives in the E.R.; Eve's sense of cabin fever and anger is calmed by a visit from her students; Morrison learns more about Eddie Carson and the `Troubles'.

Dr. Auschlander asks Fiscus and Luther to help him get some marijuana to relieve his pain; White and Daniels face the medical board hearing; Dr. Westphall defends a deaf employee against his impatient supervisor; and Ehrlich meets Roberta's snobbish parents.

Morrison learns a lesson from another doctor who makes the diagnosis of Mr. Keuhnelian; Dr. Craig prepares to accept his anticipated `Doctor of the Year' award; Dr. Caldwell and Ehrlich both make decisions about their romantic futures; Cathy's disappearance raises questions; Shirley fends off an imagined attacker; and the rapist strikes again.

Ehrlich tries to deal with his Aunt Charice and her romantic designs on Dr. Westphall as he crams for the National Boards; a stressed-out Armstrong makes a tragic misdiagnosis; White chooses to take a polygraph test before his trial begins; Shirley tells Cathy that she ""asked for it"", and Cathy's past is used to decimate her on the witness stand.

Dr. Westphall tries to deal with his critical sister-in-law and a reluctant hospital board; Luther becomes Axelrod's personal trainer; Roxanne asks Chandler to her recital; Rosenthal worries over the threats of an assaulted teenager; Dr. Caldwell's questionable behavior continues at the hospital; and Dr. Craig proves to be of little help to his grieving wife.