The guys try to help Penny out of an awkward work dilemma, when a smitten doctor shows up at her door after her flirtatious sales techniques work a little too well. Meanwhile, Amy and Bernadette argue over whether or not female scientists should play up their sexuality.

When Leonard gets minor surgery on his nose, Sheldon is the one in need of sympathy. Meanwhile, Raj's parents' impending divorce causes Howard and Bernadette to work on their own marriage.

As a joke, Sheldon and Penny try an experiment designed to make participants fall in love. Meanwhile, Leonard, Amy, Raj and Emily spend the evening trying to escape a room with a “zombie.” And, after returning from Mrs. Wolowitz’ funeral, Bernadette and Howard run into trouble at the airport.

Personalities collide when Sheldon and Leonard’s mothers finally meet. Meanwhile, Howard finally decides to “man up” and do his fair share of the housework – but not without a little help from his friends.

As Sheldon presses Leonard and Penny to set a wedding date, he encounters major changes in his own relationship with Amy. Meanwhile, Raj contemplates breaking up with Emily, and Howard and Bernadette struggle with asking Stuart to move out of their house.

The girls decide to re-enact their high school proms with the guys. While Sheldon feels under pressure to commit to his relationship with Amy, Howard worries about who Stuart will bring as his date.

Leonard and Sheldon publish a paper which is widely accepted except for comments from an internet troll. Meanwhile, the girls reminisce about embarrassing incidents from their past.

Howard receives some shocking news as everyone prepares for the reopening of Stuart’s comic book store. Penny teaches Sheldon how to “let it go,” but can’t follow her own advice after she learns something infuriating about Amy. Also, Leonard and Raj think they spot Nathan Fillion at a restaurant.

When Sheldon and Amy build a blanket fort, they come to major crossroads in their relationship. Also, Howard meets the half-brother he never knew he had. Meanwhile, Penny is invited to appear on Wil Wheaton’s podcast, but things turn awkward when Leonard joins them.

Sheldon is forced to teach a class as a Junior Professor and Howard decides to enroll in it. Meanwhile, Amy plays both sides when tension arises between Penny and Bernadette.

When Sheldon becomes stuck in a rut with his work, the gang tries to help him by raising his stress levels. Howard teases Raj with a game called "Emily or Cinnamon?"

When Leonard and Sheldon are invited to speak at UC Berkeley, they take a detour to try to meet an idol. Also, when Bernadette and Howard battle over the fate of his Doctor Who TARDIS, Raj and Amy offer to settle the dispute with a game of ping pong.

The girls head to Las Vegas for some weekend fun, while the guys try to invent something cool, but only come up with new ways to procrastinate.

Leonard and Howard turn to Raj for help in dealing with a work emergency when they nearly come to blows after blaming each other for a potential disaster at the university. Amy throws an authentic Victorian Christmas party, while Sheldon seeks revenge on her for making him celebrate the holidays.

A trip to the pet store ends in a fight after Amy learns Sheldon has applied for a one-way mission to colonize Mars. Meanwhile, Leonard surprises Penny with a very "adult" purchase, and Raj gets into trouble when he snoops around Emily's apartment.

Wolowitz feels nervous when he is asked to throw the first pitch at a Los Angeles Angels game. Penny and Leonard want to prove Sheldon wrong after he says he and Amy are the better couple.

Sheldon and Raj test whether they could survive a dark-matter research expedition in a salt mine by simulating the conditions in a steam tunnel deep underground. Meanwhile, Leonard and Penny seek advice from Howard and Bernadette after they fight about money.

Howard tries to distract Raj, who is anxiously awaiting data from a space probe he helped launch. Meanwhile, Sheldon and Leonard go dress shopping with Penny and Amy.

Leonard and Amy make an unexpected trip to Arizona to fetch Sheldon; Penny interviews for a job at Bernadette's company; Stuart's relationship with Mrs. Wolowitz disturbs Howard.

Raj's honesty comes back to haunt him when his new girlfriend is unfriendly to Penny. The guys think about becoming part owners in Stuart's store.

While Sheldon says a tearful goodbye to the final installment of "Fun with Flags", Leonard, Howard and Raj search for something significant in a dead professor's research. And Bernadette finds out what her colleagues really think of her.

Friction ensues when a magazine fails to mention Leonard in an article about the paper he co-wrote with Sheldon. Also, a blackout at Mrs. Wolowitz’s home leads to a final family dinner in her honor.

Howard questions his engineering abilities when he and Sheldon can’t get a toy drone to fly. Meanwhile, a cancelled flight nearly prevents Leonard from giving the commencement address at his former high school, and Raj pits his parents against each other when his father cuts him off financially.

When Raj is asked to create a message in case a NASA mission discovers alien life, the guys fight over what he should do. Also, Penny is torn between auditioning for a movie or keeping her successful pharmaceutical sales job.