Jo begins a pizza business with her mom's secret pizza recipe that has everyone's mouths watering, including a fraternity house that buys pizzas in bulk. However, the business begins running Jo and her workers, Natalie and Tootie ragged which leads Jo to make a business decision on how to make pizzas faster and cheaper.

Mrs. Garrett and the girls all become concerned about Blair's bizarre behavior, she's skipping class, dating nonstop and is out all night every night, all this just after a breakup with her first serious relationship, Cliff.

Blair is devastated when she learns that her boyfriend is into cocaine. Lisa Whelchel. Jo: Nancy McKeon. Kevin: Ryan Cassidy. Father Donovan: John Ingle.

The local drive-in theatre is closing and the girls decide to pay it one last visit on the final night it's open. However, chaos reigns when people begin to loot the theatre and Blair gets into a cat fight.

The girls have no plans for spring break until Natalie learns that her grandmother's condominium is available in Fort Lauderdale, where the boys are.

During an alumni weekend at Langley, Blair's mother and Jo's father bond which leads to Blair and Jo's fears of becoming sisters.

On a dateless Saturday night, the girls cruise downtown Peekskill in hopes of finding Mr. Right. However, a string of bizarre events leads the girls to hideout in their car at a closed gas station.

While working at the campus radio station, Jo finds herself needing to fill 5 hours of air time. Things start off on a bad note, when she can't find a key to the record cabinet, which leads, Natalie, Tootie, Blair and Mrs. Garrett to come to her rescue.

With computer dating as the subject of her term paper, Natalie uses a computer dating service to find Blair and Jo ""perfect dates"" without their permission. Meanwhile, Mrs. Garrett targets Tootie as a bridge partner when her old one moves away.

Tootie's first date with Jeff since he started college leaves her feeling she must sleep with him to keep him.

Mrs. Garrett and the girls share their summer vacations: Natalie and Tootie at a Cape Cod resort, Mrs. Garrett and Jo on a musical fling in Atlantic City and Blair down on a farm in Iowa.

On spring break in Fort Lauderdale and to the surprise of everyone, especially herself, Blair falls in love with a mere building manager.

For the Christmas season, Blair and some of her snobby friends plan on putting on a Christmas show at a home for boys. Her Christmas spirit quickly changes when she discovers that the home for boys is really a home for convicts.

A no-win situation: Tootie asks Natalie for an honest opinion of her dreadful one-woman play about Eleanor Roosevelt.

With Mrs. Garrett out of town, Blair wants to be in charge of the shop so a reluctant Jo, Natalie and Tootie step aside and let her. Quickly Blair's handling of a competitor food shop goes awry.

Mrs. Garrett and the girls are all excited about Natalie's graduation and buy her a bookcase with a brand new set of encyclopedias on the assumption she's going to college. To her friends surprise, Natalie has a very different plan for life after high school.

Rumors spead about Jo's involvement with her professor and indeed, they just may be true when a romance develops between the two.

Mrs. Garrett receives a visit from the high-school sweetheart she ran out on, and she's swept off her feet all over again.

Kevin, forced to leave his apartment, moves into the attic of Edna's Edibles and makes a move on Jo.

Natalie is nervous after an interview for a job she applied for with the town newspaper. However, after she learns she didn't get the job, her strange behavior threatens her relationship with her boyfriend.

The death of a famous jazz singer brings back fond memories to Tootie and Natalie, who got to know him at a resort hotel where he worked as a waiter.

Mrs. Garrett enrolls in a Shakespeare class, but worries that she might neglect her business and have trouble fitting in with the college crowd.

Jo has a heart-to-heart talk---with a computer to resolve a conflict she had with Blair (Lisa Whelchel). Natalie: Mindy Cohn. Mrs. Garrett: Charlotte Rae. Tootie: Kim Fields.

A former Eastland girl, now an author, interviews the girls for her latest book she's writing. In the interviews the girls each open up about their friendships and school life.

Jo and Sam's relationship grows more serious despite the fact that he has a young son from a previous marriage.