Longworth's latest investigation into the death of a young girl puts him at odds with a powerful political family. It appears she was having an affair with a Florida State Senator. Complicating matters is the Senator's wife who will do whatever it takes to promote her husband's political career and protect her family's name

Longworth teams up with his old partner, Detective Samantha Harper to track a serial killer from Chicago and Callie can't help but notice the obvious chemistry between them. Manus asks Callie to work as a forensic nurse for the FDLE.

In the thrilling season finale, Callie's hospital is on lockdown when a pair of ex-con brothers take hostages. Longworth and Callie work together to ensure the safety of the hostages, but things take a turn for the worst leaving Longworth to defuse the situation before it explodes.

Longworth's case involves a tribal leader found dead at a Native-American owned casino. The first hurdle is getting the tribal police to let the FDLE run point. Callie has convinced herself that she wants only friendship from Longworth but finds herself jealous seeing Josie Tigertail, a tribal police officer, interact with Longworth.

A man recently released from prison is found dead along the fairway. The victim was the caddy and life-long friend of professional golfer Scott Winters. Things don't add up for Longworth when he discovers the victim may have served time for a crime he didn't commit. The case motivates Longworth to commit to breaking 80 on the greens. Heather tempts Longworth with her cooking while Callie frets over their relationship. Daniel seeks a promotion from his intern status

The daughter of a notorious Cuban mobster turns up dead in a Little Havana alley, and Longworth and the rest of the Florida Department of Law Enforcement must solve her murder to prevent an all-out war between two rival mob families. Meanwhile, Callie prepares for her husband’s release from prison.

The murder of a woman who contacted the Innocence Project to exonerate a death row inmate now forces Jim to team up with the detective who investigated the original case: Jim's former partner when the Florida State Attorney General's office calls her to testify against the IRS agent who handled her audit and tried to extort her for sex a few years back. Reluctant to take time off to help the State Attorney, Callie is surprised when Miranda is not only supportive of her request, but also learns that Miranda has been the victim of sexual harassment herself, and the two women bond through their shared experience.

Longworth must delve into a 150-year-old ghost story to solve a murder when the dead body of an heiress is found in a haunted plantation house.

A ruthless divorce attorney is murdered. Meanwhile Callie's son, Jeff claims to have seen a man standing at his window, but Callie believes he's imagining it. Believing Jeff is telling the truth he has the boy look at mugshots on the computer, through which Jeff finds out the truth about his fathers criminal past and confronts his mom.

Longworth investigates the death of a famed treasure-hunter who was after a Spanish ship believed to contain billions of dollars in booty. Longworth must figure out if the victim was close to finding the treasure and if that's what got him killed. Callie's passion for treasure hunting lore sets her and Longworth on an adventure that just might change their lives.

Longworth's investigation of a man beaten to death in a truck stop restroom finds clues leading to a luxury rehab center. In addition to the crime, Carlo is dealing with his daughter's Quinceañera and a former colleague who needs his help. Callie and Jeff are struggling with Ray's absence

When Jim and Carlos investigate the death of a millionaire who bequeathed all his wealth to an organization of UFO enthusiasts, the organization's leader accuses the FDLE of covering up the true cause of death: an alien abduction. Meanwhile, Jim and Callie's relationship heats up, but Callie's job search to keep her in Palm Glade falters.

While Jim helps Callie settle into her new apartment in Atlanta, Carlos performs a guest autopsy for Daniel's forensics class at Tampa Tech. He discovers that the cadaver he is dissecting is actually a murder victim who turns out to be a student that was killed while participating in an on-campus pharmaceutical study. Also, the Palm Glade substation gets a new addition when FDLE Bureau Chief Jennifer Starke comes down to visit Manus, while Callie gets off to a rocky start with her new boss Dr. Miranda Buckley.

Jim gets roped into a long-standing family feud between Florida ranchers when a ranch hand turns up dead between the two family's properties. Someone from Callie's past visits her pleading for help at the worst possible time.

Jim gets called back to the golf course to catch the murderer of a golf hustler, but he's handicapped by a mad scramble to tie up loose ends for Callie and his future.

Longworth gets his first taste of a Florida hurricane, but instead of waiting out the storm, he gets swept up in a murder investigation that appears to be a spree killing and he must find the killer before there is another victim. Meanwhile, due to the storm, Callie and Carlos deal with a massive influx of patients at the hospital and a power outage leads Carlos and Daniel to take extreme measures in order to save lives.

A man suffering from head trauma claims to have witnessed a murder before being attacked and believes the murderer looks exactly like him.

Longworth and Carlos investigate a murder involving high-end horse breeding. Callie, who was once an aspiring jockey, helps them with the ins and outs of this competitive, cut-throat world. Jim sees another side of Callie which leads them to grow closer.

An 8-year old's slumber party becomes a crime scene. Callie accepts Manus' offer and joins the FDLE as a forensic nurse. Jim's investigation into the death of a Navy recruiter leads to the ex-wife's boyfriend and her missing baby

A stolen car and a body have Jim investigating some NASCAR drivers. After Ray is attacked, Callie must consider the option of witness protection.

The murder of a Haitian doctor leads Longworth and the FDLE to a pill mill and a corrupt doctor's office. Addicts have been paying big money for pain medication all of which leads to a long list of suspects.

Jeff's mentor, the high school soccer coach, is found shot dead on campus.

A body is found at a popular beachside bar with a large diamond ring in his pocket. Longworth sifts through the sands of the various characters at the bar, revealing a complicated love triange that may have ended in murder. Meanwhile, Callie has some news for Longworth that will change everything.

An Ernest Hemingway look-alike is discovered adrift under a glass bottom boat with a bullet hole in his head during a "Hemingway Days" booze cruise. Turns out, the victim might have gotten caught in the middle of a family feud between bootleggers. Meanwhile, an old romance from Callie's past reappears and drops a bombshell, one that could seriously affect her relationship with Jim, the FDLE, and the hospital.

On the day of Callie's board exam, Jim must solve the murder of a businesswoman who had founded a new surf clothing line and was about to offer the endorsement opportunity of a lifetime to a young, local surfing champion. Jim gets more frustrated over Callie's lack of communication, while a sympathetic Jennifer tries to comfort him. As he faces an uncertain future where Callie's career in Atlanta will pull her further away from her life with him in Palm Glade, Jim realizes he must make a decision on where their relationship is headed.