Longworth teams up with his old partner, Detective Samantha Harper to track a serial killer from Chicago and Callie can't help but notice the obvious chemistry between them. Manus asks Callie to work as a forensic nurse for the FDLE.

In the thrilling season finale, Callie's hospital is on lockdown when a pair of ex-con brothers take hostages. Longworth and Callie work together to ensure the safety of the hostages, but things take a turn for the worst leaving Longworth to defuse the situation before it explodes.

The daughter of a notorious Cuban mobster turns up dead in a Little Havana alley, and Longworth and the rest of the Florida Department of Law Enforcement must solve her murder to prevent an all-out war between two rival mob families. Meanwhile, Callie prepares for her husband’s release from prison.

An 8-year old's slumber party becomes a crime scene. Callie accepts Manus' offer and joins the FDLE as a forensic nurse. Jim's investigation into the death of a Navy recruiter leads to the ex-wife's boyfriend and her missing baby

Longworth's investigation of a man beaten to death in a truck stop restroom finds clues leading to a luxury rehab center. In addition to the crime, Carlo is dealing with his daughter's Quinceañera and a former colleague who needs his help. Callie and Jeff are struggling with Ray's absence

A stolen car and a body have Jim investigating some NASCAR drivers. After Ray is attacked, Callie must consider the option of witness protection.

The murder of a Haitian doctor leads Longworth and the FDLE to a pill mill and a corrupt doctor's office. Addicts have been paying big money for pain medication all of which leads to a long list of suspects.

Jeff's mentor, the high school soccer coach, is found shot dead on campus.

A body is found at a popular beachside bar with a large diamond ring in his pocket. Longworth sifts through the sands of the various characters at the bar, revealing a complicated love triange that may have ended in murder. Meanwhile, Callie has some news for Longworth that will change everything.

An Ernest Hemingway look-alike is discovered adrift under a glass bottom boat with a bullet hole in his head during a "Hemingway Days" booze cruise. Turns out, the victim might have gotten caught in the middle of a family feud between bootleggers. Meanwhile, an old romance from Callie's past reappears and drops a bombshell, one that could seriously affect her relationship with Jim, the FDLE, and the hospital.

When body parts of a Coast Guard Reservist are found in the belly of a poached wild boar, Longworth hunts the killer into the depths of the Glades. Meanwhile, Callie and Longworth decide to push the restart button on their romantic relationship.

Longworth investigates a murder in Gibtown, a community populated with human sideshow descendants, and everyone is a suspect. Jim and Callie try to figure out the exact meaning of their relationship.

The FDLE enters the battle between good and evil when a Pentecostal preacher is found dead in a snake pit. Longworth's investigation into the House of God eventually leads him to the Big House and a fatal case of mistaken identity. Meanwhile, Sam's departure has Callie questioning her own relationship with Longworth.