While Rose undergoes severe surgery, the girls try to entertain themselves with fond memories and laughter, only for Rose's daughter Kirsten to walk in on them enjoying themselves! Kirsten is spiteful of them and does not allow them to visit Rose. Kirsten visits Rose, who is near knocked out, and try to have a conversation...very comically as poor Rose is not altogether. With Rose going into surgery, Kirsten reconciles with the worried girls. At last, Rose is released and they all throw a surprise welcome home party for our lovable St. Olafian!

Blanche's uncle Lucas Hollingsworth is visiting but, to no surprise, Blanche is busy with a date. In order to be rid of his intrusion, Blanche tells Dorothy that he desperately wants to meet a woman of her intelligence. Dorothy agrees to see him but they both later learn that Blanche just lied to get rid of them and decide to get revenge by acting as though they're getting married, much to the dismay of Blanche. As a result, Rose decides she should move on to live with her daughter Kirsten to be the "Sophia of the household" as Blanche finally comes to terms with their idea to wed. Just as Lucas is about to reveal the truth, he decides to pop the question to Dorothy for real...

Dorothy accepts Lucas' proposal. The two plan to tie the knot two months later and on the way to the chapel, Dorothy takes a limo. However, this limo is driven by none other than Stanley Zbornak. The two share a rather comical but nonetheless touching moment together before arriving at the chapel. Down the aisle, along with Sophia, the girls think to themselves about the beautiful friendship they shared. Rose, Blanche and Sophia decide that the three of them should not depart and allow Dorothy on her way to Atlanta but she doesn't leave without sharing some final words with the girls...

Rose is upset when she has missed her high school reunion due to being sick, so Blanche convinces her, Dorothy and Sophia to crash a reunion held in Miami, posing as absentees from that school. Dorothy goes as the lame prom queen Cindy Lou Peoples, Blanche is the seemingly slutty Susan, Rose is the Korean exchange student Kim FongToi and Sophia is Mrs. Gonzales. With that, the girls mingle with their "former" classmates, only to realize that their counterparts lives are as dull as theirs, however, when the girls are found out by the guests...Rose has a heart attack!

The girls participate in a murder mystery weekend and Dorothy has a ball when she solves a mystery. However, when Blanche is accused committing a real murder, Dorothy will have to use all her keen detective skills to find the real murderer.

Sophia befriends an old man on the boardwalk whom she becomes quick friends with. However, his strange behavior signals that he has a medical condition, Alzheimer's disease. Meanwhile, Blanche accidentally gives away Rose's teddy bear at a garage sale.

Dorothy's old friend, Jean comes to Miami for a visit and Dorothy decides not to tell Blanche and Rose that Jean is a lesbian. Then, after spending time with Rose, Jean begins to fall for her. Meanwhile, a new VCR, prompts Sophia to rent ""dirty movies.""

The house is fumigated and the girls move into a Miami Beach hotel. Previously, Blanche had won three tickets to see the opening of Burt Reynolds new movie and passes to the party held afterwards where they could meet him. However, on the evening of the opening, the hotel is raided and, mistaken as prostitutes, Dorothy, Blanche and Rose are dragged off to jail.

Blanche's gay brother Clayton, makes a visit to Miami with a surprise, he has found the right person to make a commitment to, but Blanche still can't get over Clayton's sexual orientation. Meanwhile, Rose expects to win a Volunteer of the Year award.

One night after watching Psycho, the girls find it hard to sleep so they stay up and reminisce about how they all came to live with one another.

The girls circulate a petition to save a 200 year old oak tree which is located on the property of the most hated woman in the neighborhood, Frieda Claxton, who wants the tree cut down.

Blanche has a secret admirer and is shocked when she meets him, her supposedly dead husband, George. Meanwhile, Dorothy is being wooed by two men, Sonny Bono and Lyle Waggoner.

Blanche's brother, Clayton comes to Miami for a visit and Blanche goes all out fixing him up on blind dates. However, Rose learns the truth, Clayton is gay and is afraid to tell Blanche the truth about himself.

It is the annual Buy Sophia New Shoes day, and Dorothy is forced to take her. Blanche also tags along, mentioning that it might be fun. Meanwhile, Uncle Angelo drops by and Rose is there. Since she is trying to find a good story to report on, she is more than happy to hear Angelo's story. Apparently, his apartment building is infested with huge bugs. When the ladies watch the news, Rose insists they watch the news story about the bugs. Dorothy then tells Rose she and Stan are the landlords. Rose then tells her she didn't realize there was a family side to the story. She won't give up on the story, and a minute later, the cops show up to arrest Dorothy. They have a trial, and Stan drops his attorney for a younger woman who knows nothing. The defense lawyer is unbeatable by giving compliments to the witnesses which makes them vulnerable to his advantage. Stan and Dorothy end up losing and are forced to live in a sleasy apartment building for a while.

Rose has been dating Dr. Jonathan Newman and begins to think their relationship is leading to the altar. However she begins to have second thoughts especially since he's a midget.

Two police detectives stake out the girls' home to investigate the neighbors who are believed to be dealers in stolen gems.

It's Valentine's Day, and the girls are all excited until each one of their dates cancel at the last minute. This leaves them to reminisce about Valentine's Day past.

Dorothy continues to seek medical advice and turns to Harry Weston for help. Meanwhile, Blanche goes on a writing binge resulting in a novel that is less than enthralling.

Sophia's friend has come up with an idea that will change her life. She wants to commit suicide and she wants Sophia there to hold her hand. Meanwhile, Blanche, Rose and Dorothy become singing nursemaids to a sick baby that they are taking care of for the weekend.

Blanche is stunned when a man comes to the front door and claims to be the illegitimate son of her late husband. Meanwhile, Dorothy and Sophia enter a mother-daughter pageant at Shady Pines.

Dorothy must give the eulogy at her brother (a cross dresser), Phil's funeral. Meanwhile, a feud between Sophia and Phil's widow reaches a peak leading Sophia to reveal her hidden feelings about her son's alternative lifestyle.

The man who stood Dorothy up for her senior prom contacts her and they make a date. After learning why he stood her up, Dorothy unleashes her wrath on the person at fault, Sophia.

Late one evening, Rose brings a man home and they spend the night together. However, in the morning she finds that he has passed away. Even worse, she later discovers he was married.

A week before an awards ceremony, Blanche, Dorothy and Rose each come down with a nasty flu, which compounds their arguing over who will win a prestigious award.

Dorothy, Blanche and Rose each vie for the attention of an actor in the local community theatre, who on the sly begins romancing each of them.