Rose has been dating Miles Webber, a college professor, but the only thing they seem to have in common is the dance floor. When Miles invites her to a party, Rose feels like a fish out of water being surrounded by all his intelligent friends. Meanwhile, Blanche battles a dating slump.

Dorothy discovering Gloria sleeping with Stan just adds to their sibling rivalry and Sophia has had it so she leaves just prior the the hurricane hitting.

The full moon and festivities prompt strange happenings including Blanche's jewelry being swiped, Sophia trying to break a curse and Dorothy and Miles sharing a passionate kiss.

While Rose undergoes severe surgery, the girls try to entertain themselves with fond memories and laughter, only for Rose's daughter Kirsten to walk in on them enjoying themselves! Kirsten is spiteful of them and does not allow them to visit Rose. Kirsten visits Rose, who is near knocked out, and try to have a conversation...very comically as poor Rose is not altogether. With Rose going into surgery, Kirsten reconciles with the worried girls. At last, Rose is released and they all throw a surprise welcome home party for our lovable St. Olafian!

Blanche's uncle Lucas Hollingsworth is visiting but, to no surprise, Blanche is busy with a date. In order to be rid of his intrusion, Blanche tells Dorothy that he desperately wants to meet a woman of her intelligence. Dorothy agrees to see him but they both later learn that Blanche just lied to get rid of them and decide to get revenge by acting as though they're getting married, much to the dismay of Blanche. As a result, Rose decides she should move on to live with her daughter Kirsten to be the "Sophia of the household" as Blanche finally comes to terms with their idea to wed. Just as Lucas is about to reveal the truth, he decides to pop the question to Dorothy for real...

Dorothy accepts Lucas' proposal. The two plan to tie the knot two months later and on the way to the chapel, Dorothy takes a limo. However, this limo is driven by none other than Stanley Zbornak. The two share a rather comical but nonetheless touching moment together before arriving at the chapel. Down the aisle, along with Sophia, the girls think to themselves about the beautiful friendship they shared. Rose, Blanche and Sophia decide that the three of them should not depart and allow Dorothy on her way to Atlanta but she doesn't leave without sharing some final words with the girls...

Sophia's friend has come up with an idea that will change her life. She wants to commit suicide and she wants Sophia there to hold her hand. Meanwhile, Blanche, Rose and Dorothy become singing nursemaids to a sick baby that they are taking care of for the weekend.

Blanche has a secret admirer and is shocked when she meets him, her supposedly dead husband, George. Meanwhile, Dorothy is being wooed by two men, Sonny Bono and Lyle Waggoner.

The man who stood Dorothy up for her senior prom contacts her and they make a date. After learning why he stood her up, Dorothy unleashes her wrath on the person at fault, Sophia.

The girls participate in a murder mystery weekend and Dorothy has a ball when she solves a mystery. However, when Blanche is accused committing a real murder, Dorothy will have to use all her keen detective skills to find the real murderer.

Blanche brings a lonely, Dorothy down to the Rusty Anchor for a night of excitement. However, Blanche, had no intention of being pushed off her thrown by Dorothy, who begins singing and instantly becomes the center of attention.

Sophia befriends an old man on the boardwalk whom she becomes quick friends with. However, his strange behavior signals that he has a medical condition, Alzheimer's disease. Meanwhile, Blanche accidentally gives away Rose's teddy bear at a garage sale.

Blanche's daughter, Rebecca has some wonderful news. She's going to become a mother, through artificial insemination. However, Blanche is less than thrilled, she's totally against the entire thing.

When the company that Rose's husband worked for, cuts off their pension plan, Rose must face the fact that she's going to get a new job, one that pays more. However, she quickly finds herself dealing with something she never expected, age discrimination. Meanwhile, Sophia goes wild buying things in quantity at a Shopper's Warehouse.

Blanche is visited by her brother in-law and is taken back by his resemblence to her deceased husband. She quickly finds herself falling in love with hopes of marriage.

Dorothy finds a list of things that she wanted to accomplish before a certain age and finds that she hasn't accomplished many of them. So she decides to go after one of them, entertaining people. This leads her to sign up to do a stand up routine at a nightclub. Meanwhile, Blanche finds herself battling the IRS.

Blanche is shattered after her father, Big Daddy, passes away. However, when she goes back to her childhood home, she gets into a big argument with her sister, Virginia and decides not to attend the funeral.

It's the Christmas season and the girls are fed up with Christmas shopping in a heat wave. So they decide to buy gifts for the one person they pick from a hat. Later, the girls decide to serve Christmas dinner for the homeless, including a recently homeless Stan.

Blanche tries to lure men by placing a fake ad in the paper trying to sell a Mercedes. Meanwhile, Rose has to deal with meeting Miles's daughter who makes it clear she wants their relationship to be no more and Dorothy discovers Sophia is hoarding Social Security money, thanks to a computer error.

Dorothy becomes alarmed when Sophia forgets the date of her wedding anniversary. This leads Dorothy to face the fact that Sophia is becoming more and more forgetful with age. After visiting a doctor, Sophia decides to regain some of the memories she has lost and decides to take a trip to Brooklyn and their old apartment.

After visiting the doctor, Blanche learns that he wants to put a pacemaker in her. However, after the operation, Blanche is so scared of intimacy that she decides to give up sex.

Rose discovers that she may be carrying the HIV virus after learning the blood they used in her gallbladder operation may have contained HIV antibodies. What really gets to her though is the 72 hours she must wait before hearing the test results. Meanwhile, Dorothy organizes a Save the Swamplands charity.

Rose must decide between her boyfriend, Miles or an old boyfriend who has just come to town and asks her to go to Europe with him. Meanwhile, fed up with Dorothy's rules, Sophia decides to move out.

Blanche and her sister, Charmaine, reconcile after a life-long rivalry. However, the reconciliation does not last long after Blanche reads her recently published book and realizes the heroine is based on her. Meanwhile, Dorothy becomes fed up with Stan's visiting cousin.

The married man whom Dorothy once dated re-enters her life and has news that he's now divorced and would like to reconcile with Dorothy. Meanwhile, Blanche and Sophia become the victims of a con game.