It's time for the Isabella County Fair, which culminates in the 4-H competition. Dr. Pol and his staff are busy tending to animals that need last minute checkups to make them eligible to compete. Dr. Pol, Charles and Dr. Sandra bounce back and forth between the fair and farm calls, while Dr. Brenda holds down the fort at the clinic to deliver a set of bulldog puppies. When Dr. Pol and Charles get into a bidding war over a sheep at the fair, it's anybody's guess as to who will come out on top.

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As the temperature rises in Michigan, Dr. Pol heads to a farm to help a cow that needs calcium immediately-but if he doesn't administer it right, she'll die. Then, he helps a crippled horse that has been infected by the West Nile virus. Will he treat it, or is it too late? At the clinic, a beagle has been in labor for the past 18 hours. Dr. Pol knows that the babies are too big to come out own their own. His experience shines through as he performs an emergency cesarean section, saving her life.

The flu takes the clinic by storm, but Dr. Pol and his staff must fight through it. Dr. Brenda struggles to find out what is causing a dog to be so abnormally lethargic. She learns from his owner that it's possible he was exposed to marijuana. Dr. Brenda is relieved that the dog will be back to normal in a day. Then an entire herd of cows are too thin despite being well fed. Dr. Pol thinks it's a lack of minerals, and is surprised to find the entire herd has come down with pneumonia.

A pregnant cow has a fever, causing her to go into premature labor; Dr. Brenda removes an abscess from a puppy's head; Dr. Pol trims down a horse's teeth so it can comfortably chew.

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Dr. Pol and his son set out to solve a mystery — 10 Angus steers have suddenly gone lame and are struggling to stand. Back at the clinic, a recent widow is willing to pay whatever it costs to save her late husband's dog after the pet ingested a rock. The summer heat isn't the only thing causing Dr. Pol to sweat; he's preparing for a family reunion. Extra company makes the clinic feel jam-packed, but a few more hands provides needed relief.

It's one of Michigan's hottest summers on record, and the sweltering heat is taking a toll on both Dr. Pol and the local farm animals. Dr. Pol and Charles hope to save a newborn calf with pneumonia, but the thick blanket of humidity covering the area makes their mission even more difficult. Meanwhile, Dr. Brenda and newcomer Dr. Sandra struggle to help a stubborn pig give birth on a brutally hot day.

Before Dr. Pol is able to enjoy the Fourth of July, he must take care of animals in need. Dr. Brenda prescribes anti-anxiety medications to a puppy so she can get through the fireworks. Then, they receive a visit from a very sick dog, Gabby. Dr. Pol isn't sure what's causing her distress, and it's uncertain if she'll wake up in the morning. Then, Dr. Brenda and Dr. Sandra help a cow in labor. The calves are positioned upside-down. Will they be able to save them?

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With more than 19,000 clients, Dr. Pol is stretched to the limit. To keep up with calls, he adds Dr. Sandra to the staff. A farm girl at heart with lots of large animal experience, Dr. Sandra treats a downed horse with lesions that make it nearly impossible to stand and nurse her colt. Elsewhere, Dr. Brenda is called to treat a bloated cow in critical condition. Without treatment the cow will die, but with one simple procedure, she miraculously has him off the ground and eating in minutes.

Pol and Charles reflect back on some of the most exciting experiences in the clinic and out on farm calls over the past year.

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A veterinary student shadows Dr. Pol for a day as he treats a downed cow at a nearby farm and visits a local breeder and trainer of racehorses to ensure that the animals are in good health for breeding.