Nathan James finds itself trapped between the submarine and civilian blockades.

The fight for America comes to an end; Chandler faces a challenge that could change his life forever.

Chandler and his crew finally returns home, where a former D.C. power player is fending off a dangerous warlord who threatens her hopes of restoring law and order in society. Now with a location and a means to finalize their mission, Chandler sets out to save his dying family, only to discover something absolutely terrifying about this brave new world.

After the horrifying revelations and reversals of fortune in Baltimore, Chandler and his fractured team join forces with an underground resistance in an attempt to defeat Amy Granderson. With doses of the cure running low, Rachel tries to do some good for the sick while remaining a prisoner at Avocet. Meanwhile, Slattery and the crew of Nathan James are in a race against time to save an injured Dr. Tophet and regain control of their ship.

After a message is broadcast implicating the Navy in a devastating disaster, Chandler looks to infiltrate the network and regain the trust of the American people.

Chandler gets a lead that could help answer threatening questions. Kara does some digging in the White House.

Chandler faces his powerful enemy in a final showdown. Kara joins someone that can help with her mission.

Chandler returns to America to find out what has really been happening.

With Chandler and Tex caught in a dangerous situation, Slattery has to step into the role as commanding officer. Torn between a mission with the fate of the world at stake and a Captain (and friend) in danger, Slattery has to find a way to get his people back without losing the most important asset: the vaccine prototype.

With their mission now fully dedicated to spreading the cure, Nathan James puts a call out to civilians to meet at pre-selected ports across the country.

Chandler finds himself making a difficult decision when an order comes in from the White House.

Rachel and Chandler ask for six volunteers to participate in human trials of her vaccine, but the tests could be a living hell as the virus and the vaccine do battle inside their bodies. Meanwhile back in the States, Chandler’s wife and father are doing everything they can to keep their family alive.

The crew of Nathan James discovers that hospital ship USNS Solace was sent to sea to wait for Dr. Scott's cure. Captain Chandler sees an opportunity to add another ship to their fleet while Rachel is eager to find a lab better equipped to replicate the vaccine. When Solace fails to respond to radio communications, Chandler and his team board the ship...and come face-to-face with an unexpected enemy.

While XO Slattery struggles to evade a submarine, Chandler and his team infiltrate a compound on land.

The Nathan James must evade an overwhelming threat. A revelation in St. Louis puts President Michener in a terrible position.

After the horrifying revelations and reversals of fortune in Baltimore, Chandler and his fractured team join forces with an underground resistance in an attempt to defeat Amy Granderson. With doses of the cure running low, Rachel tries to do some good for the sick while remaining a prisoner at Avocet. Meanwhile, Slattery and the crew of Nathan James are in a race against time to save an injured Dr. Tophet and regain control of their ship.

With a small group of survivors from Solace in tow, Chandler and his crew square off against an enemy of the most dangerous kind - a nuclear-powered submarine led by rogue British naval officers, Sean and Ned Ramsey. XO Slattery interrogates a captured mercenary from the hospital ship in an effort to extract information on the sub and its mission. As Nathan James engages in a perilous game of cat-and- mouse, the truth about the mercenary sub unfolds.

Chandler's mission becomes complicated as his position is worsened. President Michener faces pressure from the regional leaders.

Chandler's mission comes to a head as he prepares the final part of his plan. President Michener ponders the fate of his presidency.

With Dr. Scott on the verge of a breakthrough, Chandler and his team set out to land in search of much needed supplies and materials for her lab.

Chandler must find a way to return to his old crew and investigate a dangerous new foe.

Still trying to piece together Dr. Hunter's lost formula, Rachel grapples with her sworn enemy's presence on board the Nathan James.

CNO Tom Chandler is sent to Asia to investigate a possible mutation of the Red Flu. Captain Slattery and his crew deliver cure to Southeast Asia but there may be an unexpected threat in the region.

America copes with tragedy while Chandler further investigates the possible virus mutation.

After picking up a distress call near Jamaica, Chandler and a small team stage a rescue attempt. But a surprise attack leave Chandler and Tex stranded at sea. Slattery and the crew search desperately to find their lost at sea Captain and his comrade, hoping to do so before their enemies beat them to it.