American gun owners shoot their penises off at an alarming rate, and Larry examines Jeb Bush's comments about black voters with DeRay Mckesson, Mike Yard and Rory Albanese.

President Obama and Vladimir Putin face off at the U.N. summit, and Larry discusses the discovery of water on Mars with Bill Nye, Michelle Buteau and Ricky Velez.

Congressional Republicans attack Planned Parenthood President Cecile Richards, and Larry discusses Donald Trump's tax plan with Robert Reich, Marina Franklin and Mike Yard.

Donald Trump faces fraud allegations from students of Trump University, and Larry discusses Russia's bombing campaign in Syria with Eddie Huang, Lisa Ling and Jordan Carlos.

Larry revisits his interview with presidential hopeful Bernie Sanders, and Rory Albanese, Mike Yard and Ashleigh Banfield weigh in on a mass shooting at an Oregon college.

Larry examines Hillary Clinton's public image, and Jessica Kirson, John Avlon and Joey Bada$$ talk about what qualities appeal to them in a presidential candidate.

California enacts a landmark death-with-dignity law, and Jay Leno, Bobby Gaylor and Michelle Collins discuss Ben Carson's surprising reaction to a mass shooting.

President Obama apologizes after American forces bomb a Doctors Without Borders hospital, and Rupert Murdoch tweets his support of Ben Carson's presidential campaign.

Nancy Pelosi joins Larry for an enlightening ice cream social, and Mike Yard, James Davis and Jeezy debate Barack Obama's legacy as America's first black president.

A toy pirate ship comes with a slave figurine, and Larry chats about the popularity of Donald Trump and Bernie Sanders with Jesse Ventura, Seaton Smith and Kathleen Madigan.

Larry examines the highs and lows of the first 2016 Democratic presidential debate with Steve Kornacki, Rory Albanese and Gabrielle Union.

Police officers gripe about being filmed by the public, and Larry discusses Jennifer Lawrence's essay on the gender pay gap with Grace Parra, Raul De Molina and Holly Walker.

Donald Trump spars with Jeb Bush over 9/11, Larry discusses Operation GroupMe with Raury, Mike Yard and Natasha Rothwell, and Raury performs a song from "All We Need."

American toddlers shoot people on a weekly basis, and Larry discusses wealth therapy for the beleaguered rich with Jeff Daniels, Rachel Feinstein and Joe Budden.

The CIA chief falls prey to hackers, and Larry discusses Joe Biden's announcement that he won't be running for president with Holly Walker, Ryan Duffy and Terry Crews.

A rash of fires plague black churches in Ferguson, Mo., and Larry discusses Rep. Paul Ryan's family leave demands with Lucy Lawless, Bonnie McFarlane and Judah Friedlander.

GOP presidential hopeful Rand Paul chats about Donald Trump over soul food, and Bob Saget, Ana Kasparian and Mike Yard discuss cringe-worthy Halloween costumes.

Republicans try to seize control of the presidential debates, and Larry discusses Ben Carson's unlikely political success with Ron Perlman, Crystal Wright and Jordan Carlos.

Ohio citizens vote against legalizing marijuana, and Larry discusses the clash between religion and science with Neil deGrasse Tyson, Tom Papa and Carl Lentz.

GOP presidential candidate Ben Carson releases a cringeworthy rap song, and Larry examines celebrity activism with Lola Ogunnaike, Niecy Nash and Bobby Gaylor.

Ricky Velez takes on racism in wrestling, and Larry discusses a study that claims all women are either bisexual or gay with Alex Berg, Mike Yard and Grace Parra.

Ricky Velez throws down with former WWE wrestler Virgil, and Larry discusses solutions to global warming with Bill Nye, Bridget Everett and Rory Albanese.

Shonda Rhimes discusses her memoir "Year of Yes," and Larry examines failing GOP presidential campaigns with Franchesca Ramsey, Steve Kornacki and Jordan Carlos.

A Starbucks holiday cup incurs the wrath of conservative Christians, and Larry grapples with the morals of killing baby Hitler with Norman Lear, Bill Engvall and Rick Ross.

Bernie Sanders and Hillary Clinton make waves at the second Democratic debate, and Larry discusses the term "radical Islam" with Dean Obeidallah, John Avlon and John Green.