Larry addresses America's obesity problem with panelists Morgan Spurlock, Marianne Kirby, Lavell Crawford and Shannon DeVido.

New York City Mayor Bill de Blasio sits down with Larry to discuss income inequality, police-community relations and the city's marijuana laws.

Joy Reid, Bonnie McFarlane, Megan Powers and Emma Iannini join Larry for a debate about legalizing guns on college campuses.

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Panelists Retta, Anne-Marie Johnson, Deborah Tillman and Pete Dominick discuss free-range parenting, government overreach and child discipline.

Dan Soder, Keith Robinson and Alex Wagner join Larry for a debate about the death penalty and the fate of convicted Boston Marathon bomber Dzhokhar Tsarnaev.

President Obama and Vladimir Putin face off at the U.N. summit, and Larry discusses the discovery of water on Mars with Bill Nye, Michelle Buteau and Ricky Velez.

Donald Trump faces fraud allegations from students of Trump University, and Larry discusses Russia's bombing campaign in Syria with Eddie Huang, Lisa Ling and Jordan Carlos.

Nancy Pelosi joins Larry for an enlightening ice cream social, and Mike Yard, James Davis and Jeezy debate Barack Obama's legacy as America's first black president.

A toy pirate ship comes with a slave figurine, and Larry chats about the popularity of Donald Trump and Bernie Sanders with Jesse Ventura, Seaton Smith and Kathleen Madigan.

Larry examines the highs and lows of the first 2016 Democratic presidential debate with Steve Kornacki, Rory Albanese and Gabrielle Union.

Police officers gripe about being filmed by the public, and Larry discusses Jennifer Lawrence's essay on the gender pay gap with Grace Parra, Raul De Molina and Holly Walker.

Donald Trump spars with Jeb Bush over 9/11, Larry discusses Operation GroupMe with Raury, Mike Yard and Natasha Rothwell, and Raury performs a song from "All We Need."

A rash of fires plague black churches in Ferguson, Mo., and Larry discusses Rep. Paul Ryan's family leave demands with Lucy Lawless, Bonnie McFarlane and Judah Friedlander.

The Texas school board takes a red pen to American history, and Larry discusses the source of Donald Trump's popularity with Pete Wentz, Ricky Velez and Holly Walker.

An infamous pharma CEO is arrested on fraud charges, and Larry revisits some of the most significant stories of 2015 with Pusha T, Rory Albanese and Mike Yard.

President Obama apologizes after American forces bomb a Doctors Without Borders hospital, and Rupert Murdoch tweets his support of Ben Carson's presidential campaign.

Ohio citizens vote against legalizing marijuana, and Larry discusses the clash between religion and science with Neil deGrasse Tyson, Tom Papa and Carl Lentz.

Ricky Velez takes on racism in wrestling, and Larry discusses a study that claims all women are either bisexual or gay with Alex Berg, Mike Yard and Grace Parra.

American gun owners shoot their penises off at an alarming rate, and Larry examines Jeb Bush's comments about black voters with DeRay Mckesson, Mike Yard and Rory Albanese.

Larry revisits his interview with presidential hopeful Bernie Sanders, and Rory Albanese, Mike Yard and Ashleigh Banfield weigh in on a mass shooting at an Oregon college.

Republicans try to seize control of the presidential debates, and Larry discusses Ben Carson's unlikely political success with Ron Perlman, Crystal Wright and Jordan Carlos.

Fox News's Brian Kilmeade brings up a racist stereotype, and Larry discusses the Planned Parenthood shooting in Colorado with Busta Rhymes, Jordan Carlos and Grace Parra.

California enacts a landmark death-with-dignity law, and Jay Leno, Bobby Gaylor and Michelle Collins discuss Ben Carson's surprising reaction to a mass shooting.